国際連携

NIBBコンファレンス - 開催リスト

The 68th NIBB Conference "Principles of Cell Communication in the Tissue"


Organizers	Shinji Takada (NIBB) Tohru Ishitani (Osaka Univ.) Jean-Paul Vincent (The Francis Crick Institute)
Venue	Okazaki Conference Center, Okazaki, Japan
Date	Nov. 13 – 15, 2022
Link	オフィシャルサイト　（https://sites.google.com/nibb.ac.jp/nibbconf68/）
	オフィシャルサイト　（https://sites.google.com/nibb.ac.jp/nibbconf68/）
Poster

Intercellular communication that is mediated by secretory signal proteins is important in the development and functional maintenance of living tissues. Indeed, many molecules related to tissue development and their functional maintenance, including secretory signal proteins, receptors for these proteins, and molecules functioning in the intercellular signaling pathway, have already been identified. As a result, the entire molecular catalog for intercellular communication has started to become ever clearer.

Nonetheless, many questions still remain concerning issues like the mechanisms underlying the establishment and regulation of the morphogen gradient, or those of the microenvironment and the stem cell niche. Recent and rapid advances in the fields of imaging techniques, quantitative analysis and methods of protein structure analysis are making it possible to analyze the dynamics and structure of the molecules involved at a much higher spatio-temporal resolution. As a result, we now have a better understanding of the potential answers to said remaining questions, resulting in a breaking of new ground in the study of this field.

In this symposium, we will focus on the interaction between Wnt ligands and membrane proteins, tissue development brought about by these signals, and the regulation of tissue polarity. We will also bring together researchers who are engaged in cutting edge research pertaining to signal transduction, while also discussing findings and issues stemming from recent studies and the direction of future research.

「組織における細胞間コミュニケーションの原理」

　本会議においては、多細胞生物の組織構築において重要な細胞間コミュニケーションに関して、さまざまな視点からの研究報告が行われ、それに対する活発な質疑応答があった。まず、構造生物学的な観点から、細胞間情報伝達に関する分泌タンパク質に関する最新の知見が紹介された。また、上皮組織における平面内細胞極性形成に関連する多くの発表があり、多階層にまたがる極性形成の分子機構について、踏み込んだ議論が活発に行われた。それとともに、細胞間でのシグナル分子の伝達機構についてサイトネームなどのさまざまな様式が紹介されるとともに、そのような伝達についての生理的意義が議論された。さらに注目を集めた発表として、構成生物学的なアプローチからシグナル分子の濃度勾配形成の再現結果などが紹介された。
　以上のように、細胞間コミュニケーションが関わるさまざまな現象を独自のアプローチにより研究する研究者が集うことにより、多面的に細胞間情報伝達を捉えることに成功するとともに、この分野において必要となる方法論や期待される成果などについての意見交換が参加者の間で進み、新たな共同研究へと発展する契機となった。
　本コンファレンスでは招待講演者による口頭発表のみならず、主に若手研究者を対象としたポスター発表の機会を設け、海外からの4演題を含めた、16演題の発表が行われた。コンファレンスオーガナイザーによる選抜により、5演題（うち国内の若手研究者3名）が口頭発表を行った。同時に、口頭発表に選ばれなかった11演題の発表に対し、若手研究者を奨励するポスター賞を実施した。オーガナイザーが指名した招待講演者2名による審査を行い、国内の大学に所属する2名に対してポスター賞を授与した。こうした機会を設けることで、将来この分野を先導する若手研究者の育成も行った。最後に、本会議を盛り上げていただいたすべての発表者・参加者の皆様、財政的支援をいただいた大幸財団、ABiS、学術変革領域研究A「多細胞生命自律性」、EMBO Reports、並びに会の運営を強力に支援していただいた研究力強化戦略室国際連携グループの皆様に深く感謝します。

高田慎治（分子発生学研究部門）

Program

Day 1: 2022.11.13 (Sun)
14:00 - 15:00	Registration

15:00 - 15:05	Opening Remarks
	Shinji Takada (National Institute for Basic Biology, Japan)

15:05 - 15:15	Message from NIBB Director General
	Kiyokazu Agata (National Institute for Basic Biology, Japan)

15:15 - 15:45	On the function of R-spondin beyond WNT signalling
	Christof Niehrs (Institute of Molecular Biology, Germany)

15:45 - 16:15	Wnts and Intercellular Communication - Some Insights from Structural Biology
	Yvonne Jones (University of Oxford, UK)

16:15 - 16:45	The "Lasso-grafted" Fc Design Platform Offers Creation of Novel Receptor Agonists and Antagonists
	Junichi Takagi (Osaka University, Japan)

16:45 - 17:00	Short Break

17:00 - 19:00	Poster Session
17:00 - 19:00	Please refer to the poster list

Day 2: 2022.11.14 (Mon)
9:15 - 9:45	Trans-Scale Polarity Formation in the Mouse Oviduct
	Toshihiko Fujimori (National Institute for Basic Biology, Japan)

9:45 - 10:00	Map7 Regulates Sertoli Cell Polarity to Support the Differentiation of Germ Cell Lineages
	Koji Kikuchi (Kumamoto University, Japan)
	Short Talk selected from Poster Presentation

10:00 - 10:30	Force Balance Controls Epithelial Cell Polarity and Behavior During Neural Tube Folding
	Sergei Y. Sokol (Icahn School of Medicine at Mount Sinai, USA)

10:30 - 10:55	Coffee Break

10:55 - 11:25	Intraflagellar Transport Complex A (IFT-A) and Kinesin 2 are Required for Nuclear Translocation of β-catenin
	Marek Mlodzik (Icahn School of Medicine at Mount Sinai, USA)

11:25 - 11:55	Molecular Mechanisms of Frizzled-Dependent Planar Polarity Establishment in Drosophila
	David Strutt (University of Sheffield, UK)

11:55 - 12:10	E3 Ubiquitin Ligase HUWE1 Regulates Planar Cell Polarity through Controlling Pk Localization
	Rieko Ajima (Okinawa Institute of Science and Technology Graduate University, Japan)
	Short Talk selected from Poster Presentation

12:10 - 12:20	Group Photo

12:20 - 13:20	Lunch

13:20 - 13:50	Telocytes Deliver Essential Wnts Directly to Intestinal Stem Cell
	David M. Virshup (Duke-NUS Medical School, Singapore)

13:50 - 14:20	Super-resolution Microscopy of Endogenous Dvl
	Michael Boutros (German Cancer Research Center (DKFZ) and Heidelberg University, Germany)

14:20 - 14:50	Cytoneme-mediated Transport of Active Wnt5b/Ror2 Complexes in Zebrafish
	Steffen Scholpp (University of Exeter, UK)

14:50 - 15:15	Coffee Break

15:15 - 15:45	Coding and decoding morphogen gradients in epithelia
	Jean-Paul Vincent (The Francis Crick Institute, UK)

15:45 - 16:15	Dpp Gradient Scaling By Recycling
	Marcos A. Gonzalez-Gaitan (University of Geneva, Switzerland)

16:15 - 16:45	Programming Multicellular Pattern Formation with Synthetic Reaction Diffusion Circuits
	Satoshi Toda (Kanazawa University, Japan)

16:45 - 17:10	Coffee Break

17:10 - 17:40	Role of Paracrine Wnt Signaling in Body Axis Elongation of Mouse Embryos
	Shinji Takada (National Institute for Basic Biology, Japan)

17:40 - 18:10	Wnt-Bandage for Bone Repair
	Shukry J. Habib (University of Lausanne, Switzerland)
	Given this presentation via Zoom

Day 3: 2022.11.15 (Tue)
9:15 - 9:45	Cell Competition Ensures Robust Formation of Morphogen Gradient
	Tohru Ishitani (Osaka University, Japan)

9:45 - 10:15	The lens-derived Wnt Coordinates Growth of Ocular Compartments
	Xin Zhang (Columbia University, USA)
	Talk selected from Poster Presentation

10:15 - 10:30	Left-right Asymmetry is Formed in the Basal Bodies of the Mouse Node Cilia in a Cilia Motility-Dependent Manner
	Hiroshi Yoke (National Institute for Basic Biology, Japan)
	Short Talk selected from Poster Presentation

10:30 - 10:55	Coffee Break

10:55 - 11:25	Regulation of Cell Polarity and Asymmetric Division by Wnts in C. elegans
	Hitoshi Sawa (National Institute of Genetics, Japan)

11:25 - 11:55	Stem Cells and Wnt Signaling in Whole Body Regeneration of Cnidarians
	Thomas W. Holstein (Center for Organismal Studeis (COS) Heidelberg, Germany)
	Talk selected from Poster Presentation

11:55 - 12:00	Closing Remarks
	Jean-Paul Vincent (The Francis Crick Institute, UK)

12:00 - 13:00	Lunch

13:00	Departure