大学共同利用機関法人 自然科学研究機構



NIBBコンファレンス - 開催リスト

The 68th NIBB Conference "Principles of Cell Communication in the Tissue"

Organizers Shinji Takada (NIBB)
Tohru Ishitani (Osaka Univ.)
Jean-Paul Vincent (The Francis Crick Institute)
Venue Okazaki Conference Center, Okazaki, Japan
Date Nov. 13 – 15, 2022
Link オフィシャルサイト (https://sites.google.com/nibb.ac.jp/nibbconf68/)
Poster The 68th NIBB Conference
Intercellular communication that is mediated by secretory signal proteins is important in the development and functional maintenance of living tissues. Indeed, many molecules related to tissue development and their functional maintenance, including secretory signal proteins, receptors for these proteins, and molecules functioning in the intercellular signaling pathway, have already been identified. As a result, the entire molecular catalog for intercellular communication has started to become ever clearer.
Nonetheless, many questions still remain concerning issues like the mechanisms underlying the establishment and regulation of the morphogen gradient, or those of the microenvironment and the stem cell niche. Recent and rapid advances in the fields of imaging techniques, quantitative analysis and methods of protein structure analysis are making it possible to analyze the dynamics and structure of the molecules involved at a much higher spatio-temporal resolution. As a result, we now have a better understanding of the potential answers to said remaining questions, resulting in a breaking of new ground in the study of this field.
In this symposium, we will focus on the interaction between Wnt ligands and membrane proteins, tissue development brought about by these signals, and the regulation of tissue polarity. We will also bring together researchers who are engaged in cutting edge research pertaining to signal transduction, while also discussing findings and issues stemming from recent studies and the direction of future research.

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 本コンファレンスでは招待講演者による口頭発表のみならず、主に若手研究者を対象としたポスター発表の機会を設け、海外からの4演題を含めた、16演題の発表が行われた。コンファレンスオーガナイザーによる選抜により、5演題(うち国内の若手研究者3名)が口頭発表を行った。同時に、口頭発表に選ばれなかった11演題の発表に対し、若手研究者を奨励するポスター賞を実施した。オーガナイザーが指名した招待講演者2名による審査を行い、国内の大学に所属する2名に対してポスター賞を授与した。こうした機会を設けることで、将来この分野を先導する若手研究者の育成も行った。最後に、本会議を盛り上げていただいたすべての発表者・参加者の皆様、財政的支援をいただいた大幸財団、ABiS、学術変革領域研究A「多細胞生命自律性」、EMBO Reports、並びに会の運営を強力に支援していただいた研究力強化戦略室国際連携グループの皆様に深く感謝します。




Day 1: 2022.11.13 (Sun)
14:00 - 15:00 Registration
15:00 - 15:05 Opening Remarks
  Shinji Takada (National Institute for Basic Biology, Japan)
15:05 - 15:15 Message from NIBB Director General
  Kiyokazu Agata (National Institute for Basic Biology, Japan)
15:15 - 15:45 On the function of R-spondin beyond WNT signalling
  Christof Niehrs (Institute of Molecular Biology, Germany)
15:45 - 16:15 Wnts and Intercellular Communication - Some Insights from Structural Biology
  Yvonne Jones (University of Oxford, UK)
16:15 - 16:45 The "Lasso-grafted" Fc Design Platform Offers Creation of Novel Receptor Agonists and Antagonists
  Junichi Takagi (Osaka University, Japan)
16:45 - 17:00 Short Break 
17:00 - 19:00 Poster Session
17:00 - 19:00 Please refer to the poster list
Day 2: 2022.11.14 (Mon) 
9:15 - 9:45 Trans-Scale Polarity Formation in the Mouse Oviduct
  Toshihiko Fujimori (National Institute for Basic Biology, Japan)
9:45 - 10:00 Map7 Regulates Sertoli Cell Polarity to Support the Differentiation of Germ Cell Lineages
  Koji Kikuchi (Kumamoto University, Japan)
  Short Talk selected from Poster Presentation
10:00 - 10:30 Force Balance Controls Epithelial Cell Polarity and Behavior During Neural Tube Folding
  Sergei Y. Sokol (Icahn School of Medicine at Mount Sinai, USA)
10:30 - 10:55 Coffee Break
10:55 - 11:25 Intraflagellar Transport Complex A (IFT-A) and Kinesin 2 are Required for Nuclear Translocation of β-catenin
  Marek Mlodzik (Icahn School of Medicine at Mount Sinai, USA)
11:25 - 11:55 Molecular Mechanisms of Frizzled-Dependent Planar Polarity Establishment in Drosophila
  David Strutt (University of Sheffield, UK)
11:55 - 12:10 E3 Ubiquitin Ligase HUWE1 Regulates Planar Cell Polarity through Controlling Pk Localization
  Rieko Ajima (Okinawa Institute of Science and Technology Graduate University, Japan)
  Short Talk selected from Poster Presentation
12:10 - 12:20 Group Photo
12:20 - 13:20 Lunch
13:20 - 13:50 Telocytes Deliver Essential Wnts Directly to Intestinal Stem Cell
  David M. Virshup (Duke-NUS Medical School, Singapore)
13:50 - 14:20 Super-resolution Microscopy of Endogenous Dvl
  Michael Boutros (German Cancer Research Center (DKFZ) and Heidelberg University, Germany)
14:20 - 14:50 Cytoneme-mediated Transport of Active Wnt5b/Ror2 Complexes in Zebrafish
  Steffen Scholpp (University of Exeter, UK)
14:50 - 15:15 Coffee Break
15:15 - 15:45 Coding and decoding morphogen gradients in epithelia
  Jean-Paul Vincent (The Francis Crick Institute, UK)
15:45 - 16:15 Dpp Gradient Scaling By Recycling
  Marcos A. Gonzalez-Gaitan (University of Geneva, Switzerland)
16:15 - 16:45 Programming Multicellular Pattern Formation with Synthetic Reaction Diffusion Circuits
  Satoshi Toda (Kanazawa University, Japan)
16:45 - 17:10 Coffee Break
17:10 - 17:40 Role of Paracrine Wnt Signaling in Body Axis Elongation of Mouse Embryos
  Shinji Takada (National Institute for Basic Biology, Japan)
17:40 - 18:10 Wnt-Bandage for Bone Repair
  Shukry J. Habib (University of Lausanne, Switzerland)
  Given this presentation via Zoom
Day 3: 2022.11.15 (Tue) 
9:15 - 9:45 Cell Competition Ensures Robust Formation of Morphogen Gradient
  Tohru Ishitani (Osaka University, Japan)
9:45 - 10:15 The lens-derived Wnt Coordinates Growth of Ocular Compartments
  Xin Zhang (Columbia University, USA)
  Talk selected from Poster Presentation
10:15 - 10:30 Left-right Asymmetry is Formed in the Basal Bodies of the Mouse Node Cilia in a Cilia Motility-Dependent Manner
  Hiroshi Yoke (National Institute for Basic Biology, Japan)
  Short Talk selected from Poster Presentation
10:30 - 10:55 Coffee Break 
10:55 - 11:25 Regulation of Cell Polarity and Asymmetric Division by Wnts in C. elegans
  Hitoshi Sawa (National Institute of Genetics, Japan)
11:25 - 11:55 Stem Cells and Wnt Signaling in Whole Body Regeneration of Cnidarians
  Thomas W. Holstein (Center for Organismal Studeis (COS) Heidelberg, Germany)
  Talk selected from Poster Presentation
11:55 - 12:00 Closing Remarks
  Jean-Paul Vincent (The Francis Crick Institute, UK)
12:00 - 13:00 Lunch
13:00 Departure