基礎生物学研究所
| Organizers | Taisen Iguchi (NIBB) |
|---|---|
| Venue | Okazaki Conference Center, Okazaki, Japan |
| Date | Nov. 30 - Dec. 2, 2015 |
| Link | オフィシャルサイト （http://www.nibb.ac.jp/conf63/） |
| Poster |
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「環境と生物」
本シンポジウムは、国際的に最前線で活躍されている研究者を交えて、「環境」と「生物」のつながりを深く議論することを目的とした。多様な種の確立に至る進化の分子基盤となる、生物の環境応答戦略に関する基礎生物学研究に加え、環境化学物質のヒトや野生生物への影響、実験動物を用いた環境化学物質の作用メカニズムに関する諸問題について議論を進めた。カブトムシ、アリ、アブラムシ、ミジンコ、メダカ、ゼブラフィッシュ、ローチ、アフリカツメガエル、アリゲーターに加えてマウスやヒトなど、様々な動物種をもちいて、環境要因による表現形の可塑性の変化の分子メカニズム、ホルモンや化学物質による変態や性分化異状、生殖の低下などの分子メカニズムについての最新の知見を元に、議論が行われた。15年前に、環境中に放出されているホルモン類似物質による魚類、両生類、爬虫類およびヒトを含めた哺乳動物への影響をどのように解析すべきかを議論するためにNIBB Conferenceを開催した。この15年間の研究の進展は目を見張るものがあり、ホルモン受容体の分子進化や機能の解明、ワニ、ミジンコ、アブラムシを含む各種動物種の性分化機構の解明、各種動物種のゲノムの解明など基礎的な理解が進むとともに、化学物質や環境によるエピジェネテイクスの変化、肥満を誘導するオベソジェンの作用機構、経世代影響、化学物質の複合影響の研究推進の必要性が明らかとなった。基礎生物学的なアプローチを元に、インフォマティクスを用いた大量のデータを用いたアプローチなど幅広い分野から、環境因子に対する生物への影響と その反応について幅広く考える機会となった。
オーガナイザー 井口泰泉
| November 30 (Mon) at the Okazaki Conference Center (OCC) | |
| 9:00 | Registration |
| Opening Remarks | |
| 10:00 - 10:30 | Masayuki Yamamoto (Director General, National Institute for Basic Biology, Japan) |
| Taisen Iguchi (National Institute for Basic Biology, Japan) | |
| Lecture 1 | |
| 10:30 - 11:15 | “From Biomolecules to Behavior: Analysis of the Impact of Environmental Factors on Thyroid Hormone-Dependent Frog Metamorphosis” |
| Caren C. Helbing (University of Victoria, Canada) | |
| 11:15 - 12:00 | “Transgenerational Inheritance of Prenatal Obesogen Exposure” |
| Bruce Blumberg (University of California, Irvine, USA) | |
| 12:00 - 12:10 | Group Photo |
| 12:10 - 13:00 | Lunch |
| Session 1: Developmental plasticity and ecotoxicology | |
| 13:00 - 13:45 | “Towards the Understanding of Sexually Dimorphic Horn Formation” |
| Teruyuki Niimi (National Institute for Basic Biology, Japan) | |
| 13:45 - 14:30 | “Evolutionary and Developmental Underpinnings of Insect Polyphenisms” |
| Toru Miura (Hokkaido University, Japan) | |
| 14:30 - 14:50 | Coffee Break |
| 14:50 - 15:35 | “Genomic revelations of mutualism: the pea aphid and its obligate bacterial symbiont” |
| Shuji Shigenobu (National Institute for Basic Biology, Japan) | |
| 15:35 - 16:20 | “Genomes as Indicators of Environmental Stress” |
| Joseph R. Shaw (Indiana University, USA) | |
| 16:20 - 16:40 | Coffee Break |
| 16:40 - 17:25 | “Phylotoxicology: Breaking the Artificial Divide Between Human- and Eco-toxicology” |
| John Colbourne (The University of Birmingham, UK) | |
| Poster Session & Mixer | |
| 17:30 - 19:30 | Poster Session & Mixer Poster Title (PDF 75KB) |
| December 1 (Tue) at OCC | |
| Session 2: Estrogen receptors and endocrine disruption | |
| 08:45 - 09:15 | “Cloning and functional characterization of Holocephalan elephant shark, Callorhinchus milii, estrogen receptors” |
| Yoshinao Katsu (Hokkaido University, Japan) | |
| 09:15 - 09:45 | “Effects of Developmental Exposure to Diethylstilbestrol on Female Reproductive Organs of Mice” |
| Tomomi Sato (Yokohama City University, Japan) | |
| 09:45 - 10:15 | “Long-Term Influences of Environmental Factors on Sex Determination and Differentiation in the American Alligator” |
| Satomi Kohno (Medical University of South Carolina, USA) | |
| 10:15 - 10:30 | Coffee Break |
| Lecture 2 | |
| 10:30 - 11:15 | “Environmental Gestagens disrupt Endocrine Systems in Amphibians” |
| Werner Kloas (Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Germany) | |
| 11:15 - 12:00 | “Development and Application of Transgenic Fish for Endocrine Disruption Chemical Research” |
| Charles R. Tyler (University of Exeter, UK) | |
| 12:00 - 13:00 | Lunch |
| Lecture 3 | |
| 13:00 - 13:45 | “Environmental Signaling: The Past and Future of Endocrine Disruption” |
| John A. McLachlan (Tulane University, USA) | |
| 13:45 - 14:00 | Coffee Break |
| Session 3: Endocrine disruptors and fish biology | |
| 14:00 - 14:30 | “Gene Expression of Vitellogenin, Choriogenin and Estrogen Receptors in the Livers of Male Medaka (Oryzias Latipes) Exposed to Equine Estrogens” |
| Koji Arizono (Prefectural University of Kumamoto, Japan) | |
| 14:30 - 15:00 | “Examination of Testing Method to Evaluate Androgenic and Anti-androgenic Potency of Chemicals Using Medaka (Oryzias latipes) and Stickleback (Gasterosteus aculeatus)” |
| Masaki Nagae (Nagasaki University, Japan) | |
| 15:00 - 15:30 | “Sex-reversal induced by steroidogenic chemicals in the medaka” |
| Tohru Kobayashi (University of Shizuoka, Japan) | |
| 15:30 - 15:45 | Coffee Break |
| Short Presentations | |
| 15:45 - 16:30 | Short Presentations from posters |
| 16:30 - 16:45 | Coffee Break |
| Session 4: Environmental research and approaches for future | |
| 16:45 - 17:15 | “Critical Appraisal and Perspectives on Gastropod Imposex Studies” |
| Toshihiro Horiguchi (National Institute for Environmental Studies, Japan) | |
| 17:15 - 17:45 | “The Concept of “Signal Toxicity” for the Planning of Research on Endocrine Disrupting Chemicals Issues” |
| Jun Kanno (National Institute of Health Sciences, Japan) | |
| 17:45 - 18:15 | “Development of Regulatory Approaches to Endocrine Disrupting Chemicals in Europe” |
| Michael Roberts (Department for Environment, Food and Rural Affairs, UK) | |
| December 2 (Wed) at OCC | |
| Session 5: Endocrine disruptions in aquatic environment | |
| 08:45 - 09:15 | “Endocrine disrupting chemicals for the invertebrate” |
| Norihisa Tatarazako (National Institute for Environmental Studies, Japan) | |
| 09:15 - 09:45 | “Nuclear receptors in the Pacific Oyster, Crassostrea gigas, reveal clear sequence homology to vertebrate species but do not directly promote the use of molluscs as surrogates for vertebrate risk assessment” |
| Tim P. Bean (Centre for Environment, Fisheries and Aquaculture Science (Cefas), UK) | |
| 09:45 - 10:15 | “Do Environmental Estrogens Induce Feminization of Wild Fish in Coastal Waters?” |
| Kiyoshi Soyano (Nagasaki University, Japan) | |
| 10:15 - 10:30 | Coffee Break |
| 10:30 - 11:00 | “The stickleback embryo toxicity test (sFET) as a platform for investigating chemical mode of action” |
| Ioanna Katsiadaki (Centre for Environment, Fisheries and Aquaculture Science (Cefas), UK) | |
| 11:00 - 11:30 | “Sexual Disruption in Roach in UK Rivers - Causes, Mechanisms and Consequences” |
| Anke Lange (University of Exeter, UK) | |
| 11:30 - 12:00 | “Effect assessment of pharmaceuticals of environmental concern- a multigenerational approach” |
| Anu Kumar (Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australia) | |
| 12:00 - 12:10 | Coffee Break |
| Closing Remarks | (Tribute to Louis J. Guillette Jr.) |
| 12:10 - 12:40 | Taisen Iguchi (National Institute for Basic Biology, Japan) |
| John A. McLachlan (Tulane University, USA) | |
