大学共同利用機関法人 自然科学研究機構



NIBBコンファレンス - 開催リスト

The 42nd NIBB Conference "Tubulin : 30 Years Later"

Organizers Hideo Mohri
Venue Okazaki Conference Center, Okazaki, Japan
Date Feb. 24-26, 1999
チュープリンは細胞内で多くの重要な働きをしている細胞骨格の一種、微小管を構成している蛋白質で、1968 年に毛利秀雄により新種の蛋白質として同定・命名された。第 42 回基礎生物学研究所コンフェレンス「TUBULIN: 30 YEARS LATER(チューブリンの30 年後)」は、チューブリン命名後 30 年を経過したのを機に、いろいろな生物を用いてチューブリンや徴小管の構造や機能を研究している国内外の第一線研究者を招いて行われ、終始活発な討論や情報交換が行われた。本会議の企画・内容についての参加者の評価は高く、この 30 年間におけるチューブリン研究の総括のみならず、今後の当該分野の研究動向を見極める上でも非常に有意義な会識であった。参加者は国外からの招待者 11 名を含め 60 名を越えたが、お互いの交流を深める上からも貴重な機会となった。なお、この会議での講演はすべて、original あるいは review paper として纏められ、Cell Structure and Function に掲載される予定である。
February 24, Wednesday
13:00-14:30 Registration
14:30 H. Mohri:
  "Opening Remarks"
14:50-17:30 Session I. Chairpersons: R. Kamiya and T. J. Itoh
14:50 K. H. Downing and E. Nogales:
  "Tubulin structure: insights on microtubule properties and functions"
15:25 K. Hirose, R. A. Cross and L.A. Amos:
  "Three-dimensional structure of the microtubule-kinesin complex"
16:00-16:20 Coffee Break
16:20 H.P. Erickson and C. Lu:
  "Site-directed mutagenesis of bacterial cell division protein FtsZ"
16:55 T. Arai, S. Takagi, A. Matsuda and T. Ohuchi:
  "Use of monoclonal antibodies to study polyglutamylation-induced conformational change in tubulin"
18:00 Mixer
February 25, Thursday
9:30-12:10 Session II. Chairpersons: M. Nishimura and H. Ishikawa
9:30 M. Caplow and S. Tillman:
  "The tubulin dimer: dynamics and equilibrium for subunit dissociation and mechanism for GTP hydrolysis"
10:05 Y. Hiraoka:
  "Fluorescence imaging of microtubule dynamics in living cells"
10:40-11:00 Coffee Break
11:00 D.Chretien:
  "Structural basis of microtubule dynamic instability"
11:35 M. Muraoka, H. Fukuzawa, A. Nishida, K. Okano, T. Tsuchihara, A. Shimoda,Y. Suzuki, M. Sato, M. Osumi and H. Sakai:
  "The effect of various GTP analogues on microtubule assembly"
12:10-13:30 Lunch
13:30-17:20 Session III. Chairpersons: H. Murofushi and H. Hotani
13:30 K. Fraire, C. M. Waterman-Storer, D. Gruber, E. D. Salmon and J. C. Bulinski:
  "Dynamic behavior of GFP-labeled E-MAP-115 (Ensconsin) in cultured cells"
14:05 S. Hisanaga and T. Kishimoto:
  "Molecular mechanism of mitotic microtubule­ destabilization by phosphorylation of MAP4 with cdc2 kinase"
14:40 L. Wilson:
  "Microtubule dynamics: potent kinetic suppression by anticancer drugs and MAPs"
15:15-15:35 Coffee Break
15:35 M. Katsuki, K. Tokuraku, H. Murofushi and S. Kotani:
  "Functional analysis of microtubule-binding domain of bovine MAP4."
16:10 P. A Curmi, 0. Gavet, E. Charbaut, S. Ozon, S. Lachkar-Colmerauer, V. Manceau, S. Siavoshian and A Sobel:
  "Biochemical and functional interaction of tubulin with stathmin family proteins"
16:45 T. J. Itoh, T. fujiwara, T. Shibuya, K. Akagawa and H. Hotani:
  "Inhibition of microtubule assembly by HPC-1/syntaxin lA, an exocytosis relating protein"
18:00 Banquet
Feburary 26, Friday
9:30-12:10 Session IV. Y. Nagahama and T. Miki-Noumura
9:30 B. R. Oakley, N. Prigozhina, C. E. Oakley and M. K. Jung:
  "Functional studies of γ-tubulin in Aspergillus nidulans"
10:05 S. Takada, T. Shibata, Y. Hiraoka and H. Masuda:
  "Role of RNR-Ml in microtubule nucleation at the centrosome"
10:40-11:00 Coffee Break
11:00 Z. Wang and M. P. Sheetz:
  "The c-terminus of tubulin increases cytoplasmic dynein and kinesin processivity"
11:35 Y. Hamaguchi:
  "Cleavage furrow formation modified by microtubule inhibitors, colchicine and taxol in sea urchin eggs"
12:10-13:30 Lunch
13:30-17:20 Session V. Chairpersons: K. Ogawa and R. Nagai
13:30 N. Shiina and S. Tsukita:
  "Regulation of microtubule organization during interphase and M phase"
14:05 D. Job:
  "STOP proteins are major effectors of microtubule stability in various cell types"
14:40 K. Fujiu and 0. Numata:
  "Localization of microtubules during macronuclear division in Tetrahymena and possible involvement of macronuclear microtubules in'amitotical'chromatin distribution"
15:15-15:35 Coffee Break
15:35 M. Kurachi, Y. Komiya and T. Tashiro:
  "Biophysical properties of stable microtubules in neurites revealed by optical techniques"
16:10 R. E. Stephens:
  "Turnover of tubulin in ciliary outer doublets"
16:45 Y. Mineyuki:
  "Diversity of MTOCS in lower land plants and the evolution of cytokinetic apparatus and spindles in higher plants"
17:20 H. Hotani
  "Concluding Remarks"