EMBO | COB Workshop "Trans-Scale Biology using exotic non-model organisms"

Organizers	重信 秀治（基礎生物学研究所） Annika Guse (Ludwig-Maximilians-Universität München, DE)
Venue	愛知県岡崎市・岡崎コンファレンスセンター
Date	July 25 – 27, 2023
Link	Official Website　（https://meetings.embo.org/event/23-trans-scale-bio）
Poster

【About the Workshop】
Recent technical innovations such as genome editing, next-generation sequencing, single-cell omics, modern imaging technologies are transforming today’s biology. The new technologies allow us to study ANY organisms at ANY levels from molecular to a group of individuals, which has been especially difficult for exotic non-model organisms until recently. Such exotic organisms facilitate exciting new questions that can be asked for the first time, or facilitate unprecedented ability to explore long-standing fundamental questions in life sciences. Also, these new technologies promote our understanding of the organisms of interest at a wide range of scales from molecular, cellular, organ, individual even to interactions between species (e.g. symbiosis and sociality), which we term "Trans-Scale Biology"

Nevertheless, establishing new models is still a big challenge. In this EMBO | Company of Biologists Workshop, we invite researchers who are pioneering new biology using exotic non-model organisms. While some issues such as breeding methods are specific to each model system, many issues including the development of genome editing and imaging protocol, genomic resources are common problems. We hope researchers can exchange useful information across the species and disciplines.

This EMBO | Company of Biologists Workshop will be held in Okazaki, Japan on the initiative of National Institute for Basic Biology (NIBB). Since NIBB is the institute serving as a center of excellence in cooperation with other universities and research organizations in Japan, we aim to nurture the scientific community of Japanese and European scientists by leveraging the framework of the EMBO|Company of Biologists Workshop.

【開催報告】
近年の技術革新のおかげで、これまで研究対象として扱いづらかった多様な「非モデル生物」の研究が可能になってきました。新しいモデルを用いることで、生命科学における新しい問いを開拓したり、あるいは長年の問いに対して斬新な視点を得たりすることができます。これらのアプローチや新しい技術は、分子、細胞、器官、個体、さらには種間の相互作用（共生や社会性など）に至るまで、多層的な生物の理解を促します。私たちはこの総合的なアプローチを「超階層生物学」と呼んでいます。本EMBO | Company of Biologists Workshopでは、非モデル生物を積極的に活用して新たな研究領域を開拓する科学者が集い、ゲノム編集や先端イメージング、ゲノムリソース開発など多彩な技術を分野や生物種の壁を超えて共有することを目指しました。

本ワークショップは3日間、岡崎コンファレンスセンターで開催され、欧州12名、米国3名、アジア74名（うち日本70名）を含む計89名が参加しました。6つのセッションにわたる21件の招待講演（日欧から1題ずつの基調講演を含む）と52件のポスター発表（うち8件はショートトーク）では、海綿、盗葉緑体ウミウシ、タツノオトシゴ、アホロートル、食虫・寄生植物、グリーンヒドラ、イソギンチャク、アブラムシ、海洋環形動物、エビ、ホタル、ユスリカなど、多様な生物群を通じた研究が披露されました。研究テーマも、発生・再生・老化、共生・寄生、発光など多岐に渡りました。さらにCRISPR/Cas9によるゲノム編集やシングルセルオミクスなどの先端手法に焦点を当てた特別セッションが設けられ、25分×2回のグループディスカッションでは、参加者が時間を忘れるほど活発な議論が繰り広げられ、新たなアイデアやコラボレーションが芽生えました。

終了後のアンケートで示された高い満足度は、このワークショップが「超階層生物学」を具現化し、その理念を広く共有する場として大きな成功を収めたことを示しています。今後は、この概念をさらに発展させるため、再開催を検討し、国際的な研究コミュニティを拡大・深化させていきたいと考えています。

 

 

Day 1 | 25 July 2023
9:00	Registration
9:30-9:45	Opening Remarks
	Shuji Shigenobu (NIBB, JP)
Session: Emerging models of marine organisms
Chair: Annika Guse (LMU Munchen, DE)
9:45-10:15	Morphogenesis in which cells act as construction workers to manipulate materials: Spiculous skeleton construction of sponges
	Noriko Funayama (Kyoto University, JP)
10:15-10:45	Kleptoplastic sea slug: Non-self chloroplast acquisition and absence of horizontal gene transfer
	Taro Maeda (Keio University, JP)
11:15-11:30	Single cell RNA sequencing gives clues for the developmental genetic basis of syngnathid’s edentulism
	Hope M. Healey (University of Oregon, US) (Poster #03)
10:45-11:15	Orphan gene expressed in flame cone cells uniquely found in seahorse epithelium
	Mari Kawaguchi (Sophia University, JP)
11:30-11:45	On the origin of appetite: GLWamide in jellyfish represents an ancestral satiety neuropeptide
	Vladimiros Thoma (Tohoku University, JP) (Poster #08)
11:45-13:00	Lunch with Poster Viewing
Session: Emerging models for regeneration and aging
Chair: Kiyokazu Agata (NIBB, JP)
13:00-13:30	Axolotl as a molecular genetic system for studying regeneration
	Elly Tanaka (IMP, AT)
13:30-13:45	Tenascin-C-enriched regeneration-specific extracellular matrix guarantees superior muscle regeneration in Ambystoma mexicanum
	Ayaka Ohashi (Okayama University, JP) (Poster #14)
13:45-14:15	Sexual development in schistosomes
	James J. Collins (UT Southwestern Medical Center, US)
14:15-14:45	Resistance to aging and carcinogenesis in the naked mole-rat: Insights from the regulation of cellular senescence and cell death
	Kyoko Miura (Kumamoto University, JP)
14:45-15:00	Break
Session: New model plants
Chair: Satoko Yoshida (NAIST, JP) and Takashi Goto (NIBB, JP)
15:00-15:30	Exploring biological questions by establishing new model plants: the moss Physcomitrium patens, the sensitive plant Mimosa pudica, the Venus flytrap Dionaea muscipula, the Albany pitcher plant Cephalotus follicularis, and the sundew Drosera rotundifolia
	Mitsuyasu Hasebe (NIBB, JP)
15:30-16:00	Genetic regulation of 3-dimensional growth in plants
	Laura Moody (Oxford University, UK)
16:00-16:30	Molecular basis for tomato resistance to the parasitic plant Cuscuta
	Neelima Sinha (UC Davis, US)
16:30-17:00	Molecular basis of the haustorium formation in the root parasitic plants in Orobanchaceae
	Satoko Yoshida (NAIST, JP)
17:00-17:15	Investigating the role of MADS-box protein binding In the evolution of seeds and flowers
	Derry Carr (The University of Birmingham, UK) (Poster #26)
17:15-17:30	Break
Poster Session (Odd numbers)
Chair: Miyo T. Morita (NIBB, JP)
17:30-18:00	Poster Flash Talks
18:00-19:00	Poster Session
19:00-20:00	Dinner
Day 2 | 26 July 2023
9:00	Registraion
Keynote
Chair: Shuji Shigenobu (NIBB, JP)
9:30-10:30	Experimental evolution of insect-microbe mutualistic symbiosis
	Takema Fukatsu (AIST, JP)
10:30-10:45	Break
Session: New symbiosis models
Chair: Mayuko Hamada (Okayama University, JP) and Tomonari Nozaki (NIBB, JP)
10:45-11:15	Adaptation to the environment through symbiosis - a model systems' approach
	Annika Guse (LMU Munchen, DE)
11:15-11:45	Diversified photosymbiotic systems in animals: Insights from the symbiosis of green hydra
	Mayuko Hamada (Okayama University, JP)
11:45-12:15	Hologenomics of aphids: an integrative view of the insect and symbionts
	Shuji Shigenobu (NIBB, JP)
12:15-12:30	Group Photo
12:30-13:30	Lunch with Poster viewing
Keynote
Chair: Annika Guse (LMU Munchen, DE)
13:30-14:30	Bridging scales in micro- and macroevolution: the marine annelid Platynereis dumerilii
	Detlev Arendt (EMBL, DE)
14:30-14:45	Break
Session: New technologies to develop emerging model organisms
Chair: Shuji Shigenobu (NIBB, JP)
14:45-15:15	DIPA-CRISPR: Insect gene editing made easy
	Takaaki Daimon (Kyoto University, JP)
15:15-15:45	Two-photon holographic microscope and 3D fluorescence imaging
	Osamu Matoba (Kobe University, JP)
15:45-16:00	Stem cells lineage reconstruction in the adult planarian using single cell transcriptomics
	Sophie Peron (Oxford Brookes University, UK) (Poster #38)
16:00-16:15	Beyond cholesterol: de novo phytosterol synthesis In animals
	Dolma Michellod (MPI for Marine Microbiology, DE) (Poster #42)
16:15-16:30	Break
Group Discussion
16:30-16:55	Theme 1:Omics
	Facilitator: Shuji Shigenobu (NIBB, JP)
	Theme 2: Genome Editing
	Facilitator: Satoshi Ansai (Kyoto University, JP) and Taro Nakamura (NIBB, JP)
	Theme 3: Bioimaging
	Facilitator: Annika Guse (LMU Munchen, DE)
16:55-17:05	Participants Reshuffling
17:05-17:30	Theme 1:Omics
	Facilitator: Shuji Shigenobu (NIBB, JP)
	Theme 2: Genome Editing
	Facilitator: Satoshi Ansai (Kyoto University, JP) and Taro Nakamura (NIBB, JP)
	Theme 3: Bioimaging
	Facilitator: Annika Guse (LMU Munchen, DE)
17:30-17:40	Break
Poster Session (Even numbers)
Chair: Miyo T. Morita (NIBB, JP)
17:40-18:10	Poster Flash Talks
18:10-19:10	Poster Session
19:10-20:00	Dinner
Day 3 | 27 July 2023
9:00	Registration
Session: Emerging model arthropods
Chair: Taro Nakamura (NIBB, JP)
9:30-10:00	Exploring the genetic basis of horn development of the Japanese rhinoceros beetle, Trypoxylus dichotomus
	Teruyuki Niimi (NIBB, JP)
10:00-10:15	A multi-partner symbiotic system in the eusocial aphid Ceratovacuna japonica
	Shunta Yorimoto (NIBB, JP) (Poster #32)
10:15-10:45	Parhyale hawaiensis: a crustacean model for epithelial morphogenesis, limb development and wood digestion
	Anastasios Pavlopoulos (FORTH, GR)
10:45-11:00	Break
11:00-11:15	A 5' UTR-overlapping lncRNA controls environmental sex determination in the freshwater crustacean Daphnia magna
	Yasuhiko Kato (Osaka University, JP) (Poster #47)
11:15-11:45	Heike firefly sheds the light on the evolution of bioluminescent properties
	Yuichi Oba (Chubu University, JP)
11:45-12:15	X-midge: origin and mechanisms of anhydrobiosis at the single-cell level.
	Oleg Gusev (Juntendo University, JP / Kazan Federal University, RU)
12:15-12:25	Closing Remarks
	Annika Guse (LMU Munchen, DE)
Excursion (Short trip to Japanese historical sites in Okazaki City)
Afternoon	Excursion

Please find the list of poster presentations here.