大学共同利用機関法人 自然科学研究機構



EMBL - シンポジウム

Biology of Protein Conjugation: Structure and Function

Organizers Yoshinori Ohsumi (NIBB), Winfried Weissenhorn (EMBL Grenoble) Biology of Protein Conjugation: Structure and Function
Venue Okazaki Conference Center, Okazaki, Japan
Date Dec. 3-5, 2006
Link Symposium Website (http://www.nibb.ac.jp/emblsymp/4th/)

embl4-1.jpg  embl4-2.jpg


 The Fourth NIBB-EMBL Symposium was held gathering distinguished researchers in the field of the biology of protein conjugation from Europe, USA and Japan. There were 27 oral presentations, of which 12 were by foreign invitees, and 18 poster presentations. The symposium was a successful one as shown in the following comment given by a participant.


 The NIBB-EMBL conference in Okazaki, Japan this past December was an outstanding international conference that included scientist from Japan, Europe and the US. It was an exciting meeting with considerable discussion both during the meeting sessions and the social activities. The program included innovative technologies in structural biology, live cell imaging and molecular biology. Each speaker presented new unpublished data and discussed the key questions that need to be addressed in their field. New insights into the roles for ubiquitin and ubiquitin-related molecules in cell signaling, membrane trafficking and protein turn-over were presented. It was the best meeting in 2006 that I attended covering these key topics in cell and molecular biology. (Scott D. Emr, UCSD, USA)

December 2 (Sat)
19:00-20:00 Registration for Invited Speakers (Okazaki New Grand Hotel)
December 3 (Sun)
08:40- Registration (Okazaki Conference Center)
09:05-09:10 Opening Remarks : Yoshitaka Nagahama (Vice President, NIBB, Japan)
09:10-09:50 Plenary Lecture : Takao Kondo (Nagoya University, Japan)
" KaiC as the Primary Pacemaker of Cyanobacterial Circadian Clock "
Session 1: SUMO      Chair: Christopher D. Lima
09:50-10:20 Hisato Saitoh (Kumamoto University, Japan)
" Involvement of SUMO-SIM Interaction in MBD1- and MCAF1-Mediated Heterochromatin Formation "
10:20-10:40 Coffee break
10:40-11:10 Ken-ichirou Morohashi (NIBB, Japan)
" Regulation of Ad4BP/SF-1 by SUMO "
11:10-11:40 Helle D. Ulrich (Cancer Research UK, UK) 
" Function of the Ubiquitin System in Replicative DNA Damage Bypass "
11:40-12:10 Masahiro Shirakawa (Kyoto University, Japan)
" Structures of SUMO-1- and SUMO-3- Conjugated Thymine DNA Glycosylase "
12:10-13:30 Lunch
Session 2-1: Membrane Biology 1      Chair: Winfried Weissenhorn
13:30-14:00 Simona Polo (IFOM, The FIRC Institute for Molecular Oncology, Milan, Italy)
" Molecular Mechanisms of Coupled Monoubiquitination "
14:00-14:30 Thomas Sommer (Max-Delbruck-Center for Molecular Medicine, Germany)
" Protein Quality Control by the HRD-Ligase Complex "
14:30-15:00 Scott D. Emr (UCSD, USA)
" Ubiquitin, PIPs and ESCRTs in Receptor Down-Regulation "
15:00-15:30 Coffee break
Session 2-2: Membrane Biology 2      Chair: Scott D. Emr
15:30-16:00 Winfried Weissenhorn (EMBL Grenoble, France)
" Structural Biology of Endosomal Vesicle Formation "
16:00-16:30 Pernille Rørth (EMBL Heidelberg, Germany)
" Guidance Mechanisms for Invasive Migration of Cell Cluster "
16:30-17:00 Soichi Wakatsuki (KEK, Japan)
" Structural Insights into Ubiquitin Recognition in Intracellular Transport "
17:00-21:00 Mixer and Poster Session
December 4 (Mon)
Session 3-1: Ubiquitin 1      Chair: Rachel E. Klevit
09:00-09:30 Hiroyuki Kawahara (Hokkaido University, Japan)
" Proteasomal Ubiquitin Receptor RPN-10 Controls TRA-2-Mediated Sex Determination inCaenorhabditis elegans "
09:30-10:00 Kazuhiro Iwai (Osaka City University, Japan)
" Identification of a Ligase Complex Polymerizing Linear Polyubiquitin Chains and Its Physiological Role "
10:00-10:30 David Fushman (University of Maryland, USA)
" Structural Studies of Polyubiquitin Chains: Conformation, Dynamics, and Ligand Binding "
10:30-10:50 Coffee break
10:50-11:20 Shigeaki Kato (The University of Tokyo, Japan)
" Functional Regulation of Nuclear Steroid Hormone Receptors through Protein Degradation "
11:20-11:50 Ivan Dikic (Johann Wolfgang Goethe University, Germany)
" Ubiquitin Signaling Pathways "
11:50-13:10 Lunch
Session 3-2: Ubiquitin 2      Chair: Kazuhiro Iwai
13:10-13:40 Takumi Kamura (Nagoya University, Japan)
" VHL-Box and SOCS-Box Domains Determine Binding Specificity for Cul2-Rbx1 and Cul5-Rbx2 Modules of Ubiquitin Ligases "
13:40-14:10 Rachel E. Klevit (University of Washington, USA)
" New Insights into the Role and Mechanism of E2 Ubiquitin-Conjugating Enzymes "
14:10-14:40 Kylie J. Walters (University of Minnesota, USA)
" The Interpreters of Ubiquitylation: How Do Ubiquitin Receptor Proteins Deliver Substrates to the Proteasome? "
14:40-15:10 Keiji Tanaka (RINSHOKEN, Japan)
" Multiple Chaperones Assist the Assembly of Mammalian 20S Proteasomes "
15:10-15:40 Coffee break
Session 4: Mechanism of UBL Conjugation      Chair: Thomas Sommer
15:40-16:10 Brenda A. Schulman (St. Jude Children's Research Hospital, USA)
" Insights into the Specificity of Ubiquitin-Like Protein Transfer Cascades "
16:10-16:40 Christopher D. Lima (Sloan-Kettering Institute, USA)
" Structural Insights into Protein Modification by SUMO "
16:40-17:00 Yoshinori Ohsumi (NIBB, Japan)
" Two Ubiquitin-Like Conjugation Systems Essential for Autophagy "
17:00-17:20 Hitoshi Nakatogawa (NIBB, Japan)
" Membrane Tethering and Fusion Mediated by Atg8, a Ubiquitin-Like Protein Required for Autophagosome Formation "
17:20-17:50 Fuyuhiko Inagaki (Hokkaido University, Japan)
" Structural Biology of Autophagy "
18:20-21:00 Social Party at Kikyu
December 5 (Tue)
Session 5: Modification by Lipid & Sugar      Chair: Koichi Kato
09:00-09:30 Akio Kihara (Hokkaido University, Japan)
" Palmitoylation of Sphingosine Kinase and Sphingosine 1-Phosphate Receptor 1 by DHHC Cys-Rich Domain-Containing Palmitoyltransferases "
09:30-10:00 Minoru Yoshida (RIKEN, Japan)
" Protein Lysine Acetylation as a Molecular Modulator for Cellular Functions "
10:00-10:20 Coffee break
10:20-10:50 Roger S. Goody (Max-Planck-Institute for Molecular Physiology, Germany)
" The Mechanistic And Structural Basis of Rab-GTPase Prenylation and Recycling "
10:50-11:20 Tadashi Suzuki (Osaka University, Japan)
" Deglycosylation of Newly Synthesized Glycoproteins by Cytoplasmic Peptide:N-glycanase (PNGase) "
11:20-11:50 Koichi Kato (Nagoya City University, Japan)
" NMR Views of Protein Conjugation with Ubiquitin and Sugar "
11:50-12:00 Closing Remarks : Yoshinori Ohsumi (NIBB, Japan)