International Cooperation

NIBB Conferences - Conference

The 68th NIBB Conference "Principles of Cell Communication in the Tissue"


Organizers	Shinji Takada (NIBB) Tohru Ishitani (Osaka Univ.) Jean-Paul Vincent (The Francis Crick Institute)
Venue	Okazaki Conference Center, Okazaki, Japan
Date	Nov. 13 – 15, 2022
Link	Official Website　（https://sites.google.com/nibb.ac.jp/nibbconf68/）

Poster

Intercellular communication that is mediated by secretory signal proteins is important in the development and functional maintenance of living tissues. Indeed, many molecules related to tissue development and their functional maintenance, including secretory signal proteins, receptors for these proteins, and molecules functioning in the intercellular signaling pathway, have already been identified. As a result, the entire molecular catalog for intercellular communication has started to become ever clearer.

Nonetheless, many questions still remain concerning issues like the mechanisms underlying the establishment and regulation of the morphogen gradient, or those of the microenvironment and the stem cell niche. Recent and rapid advances in the fields of imaging techniques, quantitative analysis and methods of protein structure analysis are making it possible to analyze the dynamics and structure of the molecules involved at a much higher spatio-temporal resolution. As a result, we now have a better understanding of the potential answers to said remaining questions, resulting in a breaking of new ground in the study of this field.

In this symposium, we will focus on the interaction between Wnt ligands and membrane proteins, tissue development brought about by these signals, and the regulation of tissue polarity. We will also bring together researchers who are engaged in cutting edge research pertaining to signal transduction, while also discussing findings and issues stemming from recent studies and the direction of future research.

Program

Day 1: 2022.11.13 (Sun)
14:00 - 15:00	Registration

15:00 - 15:05	Opening Remarks
	Shinji Takada (National Institute for Basic Biology, Japan)

15:05 - 15:15	Message from NIBB Director General
	Kiyokazu Agata (National Institute for Basic Biology, Japan)

15:15 - 15:45	On the function of R-spondin beyond WNT signalling
	Christof Niehrs (Institute of Molecular Biology, Germany)

15:45 - 16:15	Wnts and Intercellular Communication - Some Insights from Structural Biology
	Yvonne Jones (University of Oxford, UK)

16:15 - 16:45	The "Lasso-grafted" Fc Design Platform Offers Creation of Novel Receptor Agonists and Antagonists
	Junichi Takagi (Osaka University, Japan)

16:45 - 17:00	Short Break

17:00 - 19:00	Poster Session
17:00 - 19:00	Please refer to the poster list

Day 2: 2022.11.14 (Mon)
9:15 - 9:45	Trans-Scale Polarity Formation in the Mouse Oviduct
	Toshihiko Fujimori (National Institute for Basic Biology, Japan)

9:45 - 10:00	Map7 Regulates Sertoli Cell Polarity to Support the Differentiation of Germ Cell Lineages
	Koji Kikuchi (Kumamoto University, Japan)
	Short Talk selected from Poster Presentation

10:00 - 10:30	Force Balance Controls Epithelial Cell Polarity and Behavior During Neural Tube Folding
	Sergei Y. Sokol (Icahn School of Medicine at Mount Sinai, USA)

10:30 - 10:55	Coffee Break

10:55 - 11:25	Intraflagellar Transport Complex A (IFT-A) and Kinesin 2 are Required for Nuclear Translocation of β-catenin
	Marek Mlodzik (Icahn School of Medicine at Mount Sinai, USA)

11:25 - 11:55	Molecular Mechanisms of Frizzled-Dependent Planar Polarity Establishment in Drosophila
	David Strutt (University of Sheffield, UK)

11:55 - 12:10	E3 Ubiquitin Ligase HUWE1 Regulates Planar Cell Polarity through Controlling Pk Localization
	Rieko Ajima (Okinawa Institute of Science and Technology Graduate University, Japan)
	Short Talk selected from Poster Presentation

12:10 - 12:20	Group Photo

12:20 - 13:20	Lunch

13:20 - 13:50	Telocytes Deliver Essential Wnts Directly to Intestinal Stem Cell
	David M. Virshup (Duke-NUS Medical School, Singapore)

13:50 - 14:20	Super-resolution Microscopy of Endogenous Dvl
	Michael Boutros (German Cancer Research Center (DKFZ) and Heidelberg University, Germany)

14:20 - 14:50	Cytoneme-mediated Transport of Active Wnt5b/Ror2 Complexes in Zebrafish
	Steffen Scholpp (University of Exeter, UK)

14:50 - 15:15	Coffee Break

15:15 - 15:45	Coding and decoding morphogen gradients in epithelia
	Jean-Paul Vincent (The Francis Crick Institute, UK)

15:45 - 16:15	Dpp Gradient Scaling By Recycling
	Marcos A. Gonzalez-Gaitan (University of Geneva, Switzerland)

16:15 - 16:45	Programming Multicellular Pattern Formation with Synthetic Reaction Diffusion Circuits
	Satoshi Toda (Kanazawa University, Japan)

16:45 - 17:10	Coffee Break

17:10 - 17:40	Role of Paracrine Wnt Signaling in Body Axis Elongation of Mouse Embryos
	Shinji Takada (National Institute for Basic Biology, Japan)

17:40 - 18:10	Wnt-Bandage for Bone Repair
	Shukry J. Habib (University of Lausanne, Switzerland)
	Given this presentation via Zoom

Day 3: 2022.11.15 (Tue)
9:15 - 9:45	Cell Competition Ensures Robust Formation of Morphogen Gradient
	Tohru Ishitani (Osaka University, Japan)

9:45 - 10:15	The lens-derived Wnt Coordinates Growth of Ocular Compartments
	Xin Zhang (Columbia University, USA)
	Talk selected from Poster Presentation

10:15 - 10:30	Left-right Asymmetry is Formed in the Basal Bodies of the Mouse Node Cilia in a Cilia Motility-Dependent Manner
	Hiroshi Yoke (National Institute for Basic Biology, Japan)
	Short Talk selected from Poster Presentation

10:30 - 10:55	Coffee Break

10:55 - 11:25	Regulation of Cell Polarity and Asymmetric Division by Wnts in C. elegans
	Hitoshi Sawa (National Institute of Genetics, Japan)

11:25 - 11:55	Stem Cells and Wnt Signaling in Whole Body Regeneration of Cnidarians
	Thomas W. Holstein (Center for Organismal Studeis (COS) Heidelberg, Germany)
	Talk selected from Poster Presentation

11:55 - 12:00	Closing Remarks
	Jean-Paul Vincent (The Francis Crick Institute, UK)

12:00 - 13:00	Lunch

13:00	Departure