National Institute for Basic Biology
| Organizers | Masaharu Noda |
|---|---|
| Venue | Okazaki Conference Center, Okazaki, Japan |
| Date | Mar. 13-15, 2002 |
| Program | |
| Tuesday March 12 2002 | |
| 18:00-19:00 | Registration (at the Okazaki New Grand Hotel) |
| 19:00-21:00 | Welcome Party (Only for Invited Speakers from Abroad, Organizing Committee and Director- General of National Institute for Basic Biology) |
| Wednesday March 13 2002 | |
| 9:00-9:05 | Opening Remarks |
| Motoya Katsuki (Director-General of National Institute for Basic Biology, Japan) | |
| 9:05-10:05 | Opening Lecture |
| Nicholas K. Tonks (Cold Spring Harbor Laboratory, USA) | |
| "From structure to function of protein tyrosine phosphatases." | |
| 10:05-10:20 | Coffee Break |
| 10:20-12:00 | Session A: Disease and phosphatases, part I |
| 1. 10:20-11:00 | Benjamin G. Neel (Beth Israel Deaconess Medical Center, USA) |
| "Biological functions of non-receptor PTPs." | |
| 2. 11:00-11:30 | Hideki Matsui (Okayama Univ., Japan) |
| "The protein therapy inhibited myocardiac hypertrophy and protected pancreatic islet transplants through calcineurin and NF-AT cascade." | |
| 3. 11:30-12:00 | Masaharu Noda (National Institute for Basic Biology, Japan) |
| "Substrate screening and functional analysis for PTPζ(RPTPβ)." | |
| 12:00-13:40 | Lunch |
| 13:40-15:00 | Session A: Disease and phosphatases, part II |
| 4. 13:40-14:20 | Stephane Schurmans (IRIBHN,IBMM, Belgium) |
| "SHIP2 and insulin sensitivity: a role in type II diabetes mellitus?" | |
| 5. 14:20-15:00 | Anna A. DePaoli-Roach (Indiana Univ., USA) |
| "Role of protein phosphatase-1 in control of glycogen metabolism and cardiac function: Insights from transgenic and knockout mouse models." | |
| 15:00-15:20 | Coffee Break |
| 15:20-16:40 | Session B: Protein phosphatases and neural function |
| 6. 15:20-16:00 | John L. Bixby (Univ. of Miami, USA) |
| "Receptor tyrosine phosphatases in vertebrate axon growth." | |
| 7. 16:00-16:40 | Shirish Shenolikar (Duke Univ., USA) |
| "Elaborating the functions of protein phosphatase-1 in hippocampal plasticity." | |
| 17:40-17:00 | Coffee Break |
| 17:00-18:10 | Session C: Cancer and phosphatases |
| 8. 17:00-17:40 | Ramon Parsons (Columnia Univ., USA) |
| "PTEN and neoplasia." | |
| 17:40-18:10 | Tomohiko Maehama (Tokyo Metropolitan Institute of Medical Science, Japan) |
| "A novel tumor suppressor candidate interacting with the lipid phosphatase PTEN." | |
| 18:30-20:30 | Banquet |
| Thursday March 14, 2002 | |
| 9:00-10:00 | Special Lecture |
| Joseph Schlessinger (Sterling Hall of Medicine, USA) | |
| "Cellualar signaling by tyrosine phosphorylation." | |
| 10:00-10:20 | Coffee Break |
| 10:20-12:00 | Session D: Regulation of MAPK pathways by phosphatases |
| 7. 10:20-10:50 | Hiroshi Shima (Hokkaido Univ., Japan) |
| "Characterization of MKP-7, which shuttles between the nucleus and the cytoplasm." | |
| 8. 10:50-11:20 | Masato Ogata (Osaka Univ., Japan) |
| "Essential roles of MAP kinase-specific tyrosine phosphatases in mice." | |
| 6. 11:20-12:00 | Alex Hajnal (Univ. of Züich, Switzerland) |
| "The function of the C.elegans MAP kinase phosphatase LIP-1 during germline and vulval development." | |
| 12:00-13:30 | Lunch |
| 13:30-14:50 | Session E: Chemical approach to the protein phosphorylation |
| 7. 13:30-14:10 | Terrence R. Burke, Jr. (National Cancer Institure, USA) |
| "Phosphotyrosyl mimetics in the design of protein-tyrosine phosphatase inhibitors." | |
| 8. 14:10-14:50 | Christin A. Frederick (Dana-Farber Cancer Institute, USA) |
| "Structure of the cytoplasmic region of CD45." | |
| 14:50-15:05 | Cofee Break |
| 15:05-17:15 | Session F: Regulation of vascular and immune systems by phosphatases |
| 9. 15:05-15:45 | Thomas O. Daniel (Immunex Corporation, USA) |
| "Receptor tyrosine phosphatase, CD148: a critical regulator of vascular development and neovascularization." | |
| 10. 15:45-16:15 | Toshio Watanabe (Tohoku Univ., Japan) |
| "Abnormal angiogenesis but intact hematopoietic potential in PTPb2/CD148 deficient mice." | |
| 11. 16:15-15:45 | Seiji Inui (Kumamoto Univ., Japan) |
| "Function of phosphatase 2Ac-associated alpha4 in humoral immune response." | |
| 12. 15:45-17:15 | Hidetaka Yakura (Tokyo Metropolitan Institute for Neuroscience, Japan) |
| "Novel, dynamic regulation of Src-family tyrosine kinases by CD45." | |
| 17:15-18:15 | Poster session |
| 19:00 | Dinner (For Invited Speakers and Organizing Committee, at Tsukushi) |
| Friday March 15 2002 | |
| 9:00-11:55 | Session G: Regulation of signaling pathways by phosphatases |
| 13. 9:00-9:30 | Tatsuya Maeda (Tokyo Univ., Japan) |
| "Genetic analysis of the TOR pathway using Tap42p/a4, a non-conventional regulatory subunit of PP2A." | |
| 14. 9:30-10:00 | Reiko Sugiura (Kobe Univ., Japan) |
| "Functional analysis of calcineurin-mediated signaling pathway using fission yeast as a model system." | |
| 15. 10:00-10:30 | Shinri Tamura (Tohoku Univ., Japan) |
| "Molecular cloning of a novel member of protein phosphatase 2C family enriched in testicular germ cells." | |
| 10:30-10:45 | Coffee Break |
| 16. 10:45-11:15 | Takashi Matozaki (Gunma Univ., Japan) |
| "The physiological role of SHPS-1." | |
| 17. 11:15-11:55 | Rob Hooft van Huijsduijnen (Serono Pharmaceutical Research Institute, Switzerland) |
| "Identification of protein tyrosine phosphatases with specificity for the ligand- activated growth hormone receptor." | |
| 11:55-12:10 | Concluding remarks |
| Haruo Saito (Institute of Medical Science, University of Tokyo) | |
| 12:15-13:45 | Lunch |
