Dr. Akane Kawaguchi (Institute of Molecular Pathology (IMP), Austria)

2022年01月07日(金) 15:00 より 15:45 まで

オンライン開催

鈴木賢一 （7542; suzuk107[@]nibb.ac.jp）

The salamander axolotl is a well-known animal model for development, evolution, and regenerative biology. The gigantic axolotl genome size, which is 10 times bigger than human and mouse (32Gb), and their remarkable tissue regeneration ability inspire fascinating questions: How is their genome organized and packed in nuclei? How does the regulation of gene transcription occur and how is the remarkable regeneration ability governed?
In the talk, I would like to discuss two topics: In the first half, I will discuss our findings concerning axolotl genome-scale regulation from the chromosome-scale assembly project using Hi-C. The second half is that the challenges in understanding chromatin regulation during limb regeneration.

Reference.
Schloissnig S.*, Kawaguchi A.*, Nowoshilow S.*, Falcon F.*, Otsuki L., Tardivo P., Timoshevskaya N., Keinath C. M., Smith JJ., Voss SR., and Tanaka E.M. The giant axolotl genome uncovers the evolution, scaling, and transcriptional control of complex gene loci. PNAS (2021). * Co-first author

共催：新規モデル生物開発センター、再生生物学研究室

※本セミナーは英語で行われます。