Dr. Sahand Hormoz (California Institute of Technology, Division of Biology and Biological Engineering Mentor, USA)

2017年02月14日(火) 15:00 より 16:00 まで

山手3号館２階西 共通セミナー室

初期発生研究部門　藤森 俊彦 (5860)　

During development, tissue maintenance, and in diseases, cells proliferate and transition between physiologically and functionally distinct states. Despite the centrality of these transitions for diverse biological functions, it has remained challenging to determine which transitions can occur and at what rates without perturbations or cell engineering. I will discuss how quantitative cell state transition dynamics can be inferred from a static snapshot of gene expression in individual cells combined with their lineage history. We have been using synthetic biology, single-cell time-lapse microscopy, and single-molecule imaging to apply this framework to determine the dynamics of embryonic stem cells in culture. I will discuss these efforts and some counterintuitive, but beautiful, mathematical structures that have helped us interpret our experimental observations in stem cells and other biological systems.
 

References ：
Nature. 541(7635):107-111, (2017)
Cell Syst. 3 (5):419-433, (2016)
Proc Natl Acad Sci U S A. 112(18):E2281-9. (2015)

※セミナーは英語で行われます