研究概要

RESEARCH: Molecular mechanisms to change differentiated cells to stem cells (9) Cell cycle reentry from the late S or G2 phase

Assist. Prof. Masaki Ishikawa Graduate students are welcome to join.

Physcomitrella gametophore leaf cells formed in the haploid generation have 2C DNA contents. DNA synthesis and CDKA activation by CYCD are, however, required to reenter the cell cycle when leaf cells change to chloronema apical stem cells in a dissected leaf. These suggest that leaf cells are arrested at the late S-phase (Ishikawa et al. 2011). We are interested in the role of DNA synthesis in reprogramming (Ishikawa and Hasebe 2015).

Ishikawa, M. et al. (2011). Physcomitrella cyclin dependent kinase A links cell cycle reactivation to other cellular changes during reprogramming of leaf cells. Plant Cell 23, 2924-2938.

Ishikawa, M. and Hasebe, M. (2015) Cell cycle reentry from the late S or G2 phase: implications from stem cell formation in the moss Physcomitrella patens. J. Plant Res. 128, 399-405

  1. Function of STEMIN, whose induction changes differentiated cells to stem cells
  2. Epigenetic regulation during stem cell formation
  3. Role of auxin in stem cell formation
  4. Common factor for stem cell formation between animals and plants
  5. A factor to connect light and wounding signals in stem cell formation
  6. A role of histone chaperon HIRA in stem cell formation
  7. Role of ING in stem cell formation
  8. Cell cycle reentry from the late S or G2 phase
  9. Role of epigenetic regulation in stem cell formation