研究概要

RESEARCH: Molecular mechanisms to change differentiated cells to stem cells (1) Function of STEMIN, whose induction changes differentiated cells to stem cells

Mio Morishita (graduate student in SOKENDAI [The Graduate University for Advanced Studies]) and Assist. Prof. Masaki Ishikawain collaboration with Assist. Prof. Yohei Higuchi in Univ. Tokyo and Assoc. Prof. Yoshikatsu Sato in Nagoya Univ.

Induction of a transcription factor STEMIN changes Physcomitrella leaf cells to chloronema apical stem cells. We are interested in the reason why a single gene can start reprogramming of differentiated cells to stem cells with analyzing its gene regulatory network.

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  1. Function of STEMIN, whose induction changes differentiated cells to stem cells
  2. Epigenetic regulation during stem cell formation
  3. Role of auxin in stem cell formation
  4. Common factor for stem cell formation between animals and plants
  5. A factor to connect light and wounding signals in stem cell formation
  6. A role of histone chaperon HIRA in stem cell formation
  7. Role of ING in stem cell formation
  8. Cell cycle reentry from the late S or G2 phase
  9. Role of epigenetic regulation in stem cell formation