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Press Release

2018.12.21

How sperm stem cells maintain their number

The steady production of sperm relies on the number of sperm stem cells in the testis remaining constant. Researchers including Asst. Prof. Yu Kitadate and Prof. Shosei Yoshida (developmental biologists at the National Institute for Basic Biology within the National Institutes of Natural Sciences in Japan) and Prof. Benjamin Simons (a theoretical physicist at the University of Cambridge in the UK) have revealed a novel mechanism for stem cell number control. Their results show that constant sperm stem cell numbers are achieved, in mouse testes, through a self-organized process in which they actively migrate and compete for a limited supply of self-renewal-promoting fibroblast growth factors (FGFs). This study was published on line in Cell Stem Cell on Nov. 20th, 2018.

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