Dr. Jinrong Min (University of Tronto, Structural Genomics Consortium and Physiology, Faculty of Medicine, Professor)

2022. 11. 08 (Tue) 16:00 ~ 17:00

Seminar Room 1, Myodaiji (132-134) and Zoom (hybrid)

Jun-ichi Nakayama [Division of Chromatin Regulation] (7681)

In the human genome, there are about 200 potential methyl-lysine or methyl-arginine binding proteins. A common feature of these proteins is that they all utilize an aromatic cage to recognize the methyl-lysine or methyl-arginine residue. These proteins have diverse methylation state and sequence selectivity. This presentation will focus on the ‘Royal Family’ of proteins, which includes the chromodomain, Tudor, PWWP, and MBT domain containing proteins. The Royal superfamily shares a common structural feature, an antiparallel β-barrel-like fold. It will show how the members of these ‘Royal Family’ of proteins selectively bind to their ligands, and how the information gained from the systematic characterization of these proteins is used to design target-specific antagonist or chemical probes.