National Institute for Basic Biology
(Written in 2023)
The morphology of the body and tissues is established in a spatio-temporarily regulated manner. A number of genes involved in the process of morphogenesis have been identified, but it is still uncertain how either spatial and temporal information are established and converted to morphology during embryogenesis. Therefore, our aim is to understand the mechanism by which this spatial information is established, and how temporal and periodical information is converted into morphology through the application of several different approaches.
Yabe, T., Uriu, K., Takada, S. (2023). Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation. Nat. Commun. 14, 2115.
Hatakeyama, Y., Saito, N., Mii, Y., Takada, R., Shinozuka, T., Takemoto, T., Honda, N., Takada, S. (2023). Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis. Nat. Commun. 14, 1924.
Mii, Y., Nakazato, K., Pack, C.-G., Ikeda, T., Sako, Y., Mochizuki, A., Taira, M., Takada, S. (2021). Quantitative analyses reveal extracellular dynamics of Wnt ligands in Xenopus embryos. eLife 10, e55108.
Shinozuka, T., Takada, R., Yoshida, S., Yonemura, S., Takada, S. (2019). Wnt produced by stretched roof-plate cells is required for the promotion of cell proliferation around the central canal of the spinal cord. Development 146, dev159343.
Takada, R., Mii, Y., Krayukhina, E., Maruyama, Y., Mio, K., Sasaki, Y., Shinkawa, T., Pack, C.-G., Sako, Y., Sato, C., Uchiyama, S., Takada, S. (2018). Assembly of protein complexes restricts diffusion of Wnt3a proteins. Commun. Biol. 1, 165.
Mii, Y., Yamamoto, T., Takada, R., Mizumoto, S., Matsuyama, M., Yamada, S., *Takada, S., and *Taira, M. (*Co-corresponding authors) (2017). Roles of two types of heparan sulphate clusters in Wnt8 distribution and signalling in Xenopus. Nat. Commun. 8, 1973.
