研究成果
発表論文(平成28年度~平成29年度)
- 1.Sparvoli D, Richardson E, Osakada H, Lan X, Iwamoto M, Bowman GR, Kontur C, Bourland WA, Lynn DH, Pritchard JK, Haraguchi T, Dacks JB, Turkewitz AP.
- Remodeling the Specificity of an Endosomal CORVET Tether Underlies Formation of RegulatedSecretory Vesicles in the Ciliate Tetrahymena thermophila.
- Curr Biol. 2018 Mar 5;28(5):697-710.e13
- Pubmed ID: 29478853 [国際活動支援班の成果]
- 2.Itoh G, Ikeda M, Iemura K, Amin MA, Kuriyama S, Tanaka M, Mizuno N, Osakada H, Haraguchi T, Tanaka K.
- Lateral attachment of kinetochores to microtubules is enriched in prometaphase rosette and facilitates chromosome alignment and bi-orientation establishment.
- Sci Rep. ,2018 Mar 1;8(1):3888.
- Pubmed ID: 29497093 [領域内共同研究:原口、田中]
- 3.Asakawa H, Hiraoka Y, Haraguchi T.
- Estimation of GFP-Nucleoporin Amount Based on Fluorescence Microscopy.
- Methods Mol Biol. ,2018;1721:105-115. doi: 10.1007/978-1-4939-7546-4_10.
- Pubmed ID: 29423851 責任著者 [領域内共同研究:淺川、平岡、原口]
- 4.Tsuchiya M, Ogawa H, Koujin T, Mori C, Osakada H, Kobayashi S, Hiraoka Y, Haraguchi T.
- p62/SQSTM1 promotes rapid ubiquitin conjugation to target proteins after endosome rupture during xenophagy.
- FEBS Open Bio , 2018 Jan 23. doi: 10.1002/2211-5463.12385
- (web: http://onlinelibrary.wiley.com/doi/10.1002/2211-5463.12385/full)
- 責任著者 [領域内共同研究:平岡、原口]
- 5.Hirano Y, Kinugasa Y, Asakawa H, Chikashige Y, Obuse C, Haraguchi T, Hiraoka Y.
- Lem2 is retained at the nuclear envelope through its interaction with Bqt4 in fission yeast.
- Genes Cells. , 2018 Jan 2.
- Pubmed ID: 29292846 [領域内共同研究:淺川、小布施、原口、平岡]
- 6.Iwamoto M, Hiraoka Y, Haraguchi T.
- Newly found Tetrahymena nucleoporins, Nup214, Nup153 and Pom121/Pom82, differentiate nuclear pore complexes of functionally distinct nuclei.
- Commun Integrat Biol. , 2017, Nov 03
- (web: http://www.tandfonline.com/doi/full/10.1080/19420889.2017.1384890)
- 責任著者 [領域内共同研究:平岡、原口]
- 7.Yang HJ, Iwamoto M, Hiraoka Y, Haraguchi T.
- Function of nuclear membrane proteins in shaping the nuclear envelope integrity during closed mitosis.
- J Biochem. , 161(6):471-477 doi:10.1093/jb/mvx020.
- Pubmed ID: 28398483 責任著者 [領域内共同研究:平岡、原口]
- 8.Iwamoto M, Osakada H, Mori C, Fukuda Y, Nagao K, Obuse C, Hiraoka Y, Haraguchi T.
- Compositionally distinct nuclear pore complexes of functionally distinct dimorphic nuclei in ciliate Tetrahymena.
- J. Cell Sci.,2017
- Pubmed ID:28386019 責任著者 [領域内共同研究:小布施・平岡・原口]
- 9.Kaur H, Sparvoli D, Osakada H, Iwamoto M, Haraguchi T, Turkewitz AP.
- A late endosomal syntaxin and the AP-3 complex are required for formation and maturation of lysosome-related secretory organelles (mucocysts) in Tetrahymena thermophila .
- Mol. Biol. Cell.,2017 April 5.
- Pubmed ID: 28381425 [国際活動支援班の成果]
- 10.Chikashige Y, Yamane M, Okamasa K, Osakada H, Tsutsumi C, Nagahama Y, Fukuta N, Haraguchi T, Hiraoka Y.
- Fission yeast APC/C activators Slp1 and Fzr1 sequentially trigger two consecutive nuclear divisions during meiosis.
- FEBS Lett.,2017 Feb 28.
- Pubmed ID: 28245054 [領域内共同研究:原口・平岡]
- 11. Yang HJ, Osakada H, Kojidani T, Haraguchi T, Hiraoka Y.
- Lipid droplet dynamics during Schizosaccharomyces pombe sporulation and their role in spore survival.
- Biol Open.,2017 Jan 3. pii: bio.022384.
- Pubmed ID: 28011631 [領域内共同研究:原口・平岡]
- 12. Koyama M, Nagakura W, Tanaka H, Kujirai T, Chikashige Y, Haraguchi T, Hiraoka Y, Kurumizaka H.
- In vitro reconstitution and biochemical analyses of the Schizosaccharomyces pombe nucleosome.
- Biochem Biophys Res Commun. , 2016
- Pubmed ID: 27890612 [領域内共同研究:原口・平岡・胡桃坂]
- 13. Matsuda A, Asakawa H, Haraguchi T, Hiraoka Y.
- Spatial organization of the Schizosaccharomyces pombe genome within the nucleus.
- Yeast.,2016 Oct 21.
- Pubmed ID: 27766670 [領域内共同研究:淺川・原口・平岡]
- 14. Sato Y, Kujirai T, Arai R, Asakawa H, Ohtsuki C, Horikoshi N, Yamagata K, Ueda J, Nagase T, Haraguchi T, Hiraoka Y, Kimura A, Kurumizaka H, Kimura H.
- A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation.
- J Mol Biol. ,Oct 9;428(20):3885-3902.
- Pubmed ID: 27534817 [領域内共同研究:木村・浅川・原口・山縣・上田・平岡・胡桃坂]
- Live correlative light-electron microscopy to observe molecular dynamics in high resolution.
- Microscopy (Oxf). ,2016 Aug;65(4):296-308.
- Pubmed ID: 27385786 責任著者
- Identification of Conserved MEL-28/ELYS Domains with Essential Roles in Nuclear Assembly and Chromosome Segregation
- PLoS Genet, 2016
- Pubmed ID: 27341616 [領域内共同研究:原口・平岡]
- Inner nuclear membrane protein Lem2 augments heterochromatin formation in response to nutritional conditions.
- Genes Cells,2016 Aug;21(8):812-32.
- Pubmed ID: 27334362 [領域内共同研究:淺川・原口・平岡]
- 18. Tsuchiya M, Ogawa H, Koujin T, Kobayashi S, Mori C, Hiraoka Y, Haraguchi T.
- Depletion of autophagy receptor p62/SQSTM1 enhances the efficiency of gene delivery in mammalian cells.
- FEBS Lett,2016 Aug;590(16):2671-80.
- Pubmed ID: 27317902 責任著者、[領域内共同研究:平岡・原口]
発表論文(平成25年度~平成27年度)
- 1. Iwamoto, M., Hiraoka, Y., Haraguchi, T.
- Uniquely designed nuclear structures of lower eukaryotes
- Current Opinion in Cell Biology, 2016
- Pubmed ID: 26963276 責任著者 [領域内共同研究:平岡・原口]
- 2. Ding, D. Q., Haraguchi, T., and Hiraoka, Y.
- A cohesin-based structural platform supporting homologous chromosome pairing in meiosis
- Curr Genet, 2016
- Pubmed ID: 26856595 [領域内共同研究:原口・平岡]
- 3. Asakawa, H., Yang, H.-J., Hiraoka, Y., Haraguchi, T.
- Virtual nuclear envelope breakdown and its regulators in fission yeast meiosis
- Front. Cell Dev. Biol, 2016
- Pubmed ID: 26870731 責任著者 [領域内共同研究:淺川・平岡・原口]
- 4. Yang, H. J., Haraguchi, T., and Hiraoka, Y.
- A nucleoporin that facilitates meiotic kinetochore reorganization
- Cell Cycle, 2016
- Pubmed ID: 26727711 [領域内共同研究:原口・平岡]
- 5. Ohtsuki, T., Miki, S., Kobayashi, S., Haraguchi, T., Nakata, E., Hirakawa, K., Sumita, K., Watanabe, K., and Okazaki, S.
- The molecular mechanism of photochemical internalization of cell penetrating peptide-cargo-photosensitizer conjugates
- Sci Rep, 2015
- Pubmed ID: 26686907
- 6. Yamamoto, J., Oura, M., Yamashita, T., Miki, S., Jin, T., Haraguchi, T., Hiraoka, Y., Terai, H., and Kinjo, M.
- Rotational diffusion measurements using polarization-dependent fluorescence correlation spectroscopy based on superconducting nanowire single-photon detector
- Optics Express,2015
- Pubmed ID: 26699052 [領域内共同研究:原口・平岡]
- 7. Ding, D. Q., Matsuda, A., Okamasa, K., Nagahama, Y., Haraguchi, T., and Hiraoka, Y.
- Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe
- Chromosoma, 2015
- Pubmed ID: 26511279 [領域内共同研究:平岡・原口]
- 8. Chikashige, Y., Arakawa, S., Leibnitz, K., Tsutsumi, C., Mori, C., Osakada, H., Murata, M., Haraguchi, T., and Hiraoka, Y.
- Cellular economy in fission yeast cells continuously cultured with limited nitrogen resources
- Sci Rep 5, 15617, 2015
- Pubmed ID: 26486373 [領域内共同研究:原口・平岡]
- 9. Yang, H. J., Asakawa, H., Haraguchi, T., and Hiraoka, Y.
- Nup132 modulates meiotic spindle attachment in fission yeast by regulating kinetochore assembly
- J Cell Biol, 2015
- Pubmed ID: 26483559 [領域内共同研究:淺川・原口・平岡]
- 10. Tsuchiya, M., Isogai, S., Taniguchi, H., Tochio, H., Shirakawa, M., Morohashi, K., Hiraoka, Y., Haraguchi, T., and Ogawa, H.
- Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation
- Sci Rep 5, 14498, 2015
- Pubmed ID:26412716 [領域内共同研究:平岡・原口]
- 11. Iwamoto, M., Hiraoka, Y., Haraguchi, T.
- The nuclear pore complex acts as a master switch for nuclear differentiation
- Commun Integr Biol , 2015
- Pubmed ID:26479399 責任著者 [領域内共同研究:平岡、原口]
- 12. Kobayashi, S., Haraguchi, T.
- A novel pathway to detect and cope with exogenous dsDNA
- Commun Integr Biol, 2015
- (web : http://www.tandfonline.com/doi/full/10.1080/19420889.2015.1065361#abstract) 責任著者
- 13. Ruan, K., Yamamoto, T. G., Asakawa, H., Chikashige, Y., Kimura, H., Masukata, H., Haraguchi, T., and Hiraoka, Y.
- Histone H4 acetylation required for chromatin decompaction during DNA replication
- Sci Rep , 2015
- Pubmed ID: 4520004 [領域内共同研究:淺川・木村・原口・平岡]
- 14. Matsuda, A., Chikashige, Y., Ding, D. Q., Ohtsuki, C., Mori, C., Asakawa, H., Kimura, H., Haraguchi, T., and Hiraoka, Y.
- Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast
- Nat Commun , 2015
- Pubmed ID: 26205977 [領域内共同研究:淺川・木村・原口・平岡]
- 15. Asakawa, H., Mori, C., Ohtsuki, C., Iwamoto, M.
Hiraoka, Y., Haraguchi, T.
- Uncleavable Nup98-Nup96 is functional in the fission yeast Schizosaccharomyces pombe
- FEBS Open Bio , 2015
- Pubmed ID: 26137436 責任著者 [領域内共同研究:淺川・平岡・原口]
- 16. Kobayashi, S., Koujin, T., Kojidani, T., Osakada, H., Mori, C., Hiraoka, Y., and Haraguchi, T.
- BAF is a cytosolic DNA sensor that leads to exogenous DNA avoiding autophagy
- Proc Natl Acad Sci U S A, 2015
- Pubmed ID: 25991860 責任著者 [領域内共同研究:原口・平岡]
- ※毎日新聞、朝日新聞、神戸新聞、web newsなどで取りあげられました。
- 17. Iwamoto, M., Koujin, T., Osakada, H., Mori, C., Kojidani, T., Matsuda, A., Asakawa, H., Hiraoka, Y., and Haraguchi, T.
- Biased assembly of the nuclear pore complex is required for somatic and germline nuclear differentiation in Tetrahymena
- J Cell Sci 128, 1812-1823, 2015
- Pubmed ID: 25788697 責任著者 [領域内共同研究:原口・淺川・平岡]
- 19. Haraguchi, T., Osakada, H., and Koujin, T.
- Live CLEM imaging to analyze nuclear structures at high resolution
- Methods Mol Biol , 2015
- Pubmed ID: 25555577 責任著者、筆頭著者
- 20. Ruan, K., Yamamoto, T. G., Asakawa, H., Chikashige, Y., Masukata, H., Haraguchi, T., and Hiraoka, Y.
- Meiotic nuclear movements in fission yeast are regulated by the transcription factor Mei4 downstream of a Cds1-dependent replication checkpoint pathway
- Genes Cells , 2015
- Pubmed ID: 25492408 [領域内共同研究:平岡・原口・淺川]
- 21. Yamashita, T., Liu, D., Miki, S., Yamamoto, J., Haraguchi, T., Kinjo, M., Hiraoka, Y., Wang, Z., and Terai, H.
- Fluorescence correlation spectroscopy with visible-wavelength superconducting nanowire single-photon detector
- Opt Express 22, 28783-28789, 2014
- Pubmed ID: 25402117 [領域内共同研究:原口・平岡]
- 22. Oana, H., Nishikawa, K., Matsuhara, H., Yamamoto, A., Yamamoto, T. G., Haraguchi, T., Hiraoka, Y., and Washizu, M.
- Non-destructive handling of individual chromatin fibers isolated from single cells in a microfluidic device utilizing an optically driven microtool
- Lab Chip 14, 696-704, 2014
- Pubmed ID: 24356711 [領域内共同研究:原口・平岡]
- 23. Kuramoto, K., Sakai, F., Yoshinori, N., Nakamura, T. Y., Wakabayashi, S., Kojidani, T., Haraguchi, T., Hirose, F., and Osumi, T.
- Deficiency of a lipid droplet protein, perilipin 5, suppresses myocardial lipid accumulation, thereby preventing type 1 diabetes-induced heart malfunction
- Mol Cell Biol 34, 2721-2731, 2014
- Pubmed ID: 24820416
- 24. Iwamoto, M., Mori, C., Hiraoka, Y., and Haraguchi, T.
- Puromycin resistance gene as an effective selection marker for ciliate Tetrahymena
- Gene 534, 249-255, 2014
- Pubmed ID: 24185080 責任著者 [領域内共同研究:平岡・原口]
- 25. Chikashige, Y., Yamane, M., Okamasa, K., Mori, C., Fukuta, N., Matsuda, A., Haraguchi, T., and Hiraoka, Y.
- Chromosomes rein back the spindle pole body during horsetail movement in fission yeast meiosis
- Cell Struct Funct 39, 93-100, 2014
- Pubmed ID: 24954111 [領域内共同研究:平岡・原口]
- 26. Asakawa, H., Yang, H. J., Yamamoto, T. G., Ohtsuki, C., Chikashige, Y., Sakata-Sogawa, K., Tokunaga, M., Iwamoto, M., Hiraoka, Y., and Haraguchi, T.
- Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe
- Nucleus 5, 149-162, 2014
- Pubmed ID: 24637836 責任著者 [領域内共同研究:淺川・平岡・原口]
- 27. Asakawa, H., Hiraoka, Y., and Haraguchi, T. A method of correlative light and electron microscopy for yeast cells
- Micron 61, 53-61, 2014
- Pubmed ID: 24792447 責任著者 [領域内共同研究:淺川・平岡・原口]
- 28. Iwamoto, M., Asakawa, H., Ohtsuki, C., Osakada, H., Koujin, T., Hiraoka, Y., and Haraguchi, T.
- Monoclonal antibodies recognize gly-leu-phe-gly repeat of nucleoporin nup98 of tetrahymena, yeasts, and humans
- Monoclon Antib Immunodiagn Immunother 32, 81-90, 2013
- Pubmed ID: 23607342 責任著者 [領域内共同研究:平岡・原口]
- 29. Fujita, N., Morita, E., Itoh, T., Tanaka, A., Nakaoka, M., Osada, Y., Umemoto, T., Saitoh, T., Nakatogawa, H., Kobayashi, S., Haraguchi, T., Guan, J. L., Iwai, K., Tokunaga, F., Saito, K., Ishibashi, K., Akira, S., Fukuda, M., Noda, T., and Yoshimori, T.
- Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin
- J Cell Biol 203, 115-128, 2013
- Pubmed ID: 24100292
- 30. Ding, D. Q., Haraguchi, T., and Hiraoka, Y.
- The role of chromosomal retention of noncoding RNA in meiosis
- Chromosome Res 21, 665-672, 2013
- Pubmed ID: 24173580 [領域内共同研究:平岡・原口]
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