新学術領域研究「動的クロマチン構造と機能」

研究成果

Publication 2016～2017

Estimation of GFP-Nucleoporin Amount Based on Fluorescence Microscopy.
Methods Mol Biol. ,2018;1721:105-115. doi: 10.1007/978-1-4939-7546-4_10.
Pubmed ID: 29423851

2.Tsuchiya M, Ogawa H, Koujin T, Mori C, Osakada H, Kobayashi S, Hiraoka Y, Haraguchi T.
p62/SQSTM1 promotes rapid ubiquitin conjugation to target proteins after endosome rupture during xenophagy.
FEBS Open Bio , 2018 Jan 23. doi: 10.1002/2211-5463.12385
(web: http://onlinelibrary.wiley.com/doi/10.1002/2211-5463.12385/full）

3.Hirano Y, Kinugasa Y, Asakawa H, Chikashige Y, Obuse C3,, Haraguchi T, Hiraoka Y.
Lem2 is retained at the nuclear envelope through its interaction with Bqt4 in fission yeast.
Genes Cells. , 2018 Jan 2.
Pubmed ID: 29292846

4.Kajitani T, Kato H, Chikashige Y, Tsutsumi C, Hiraoka Y, Kimura H, Ohkawa Y, Obuse C, Hermand D, Murakami Y
Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi.
PNAS., 2017 Dec 26;114(52):E11208-E11217. doi: 10.1073/pnas.1714579115. Epub 2017 Dec 13.
Pubmed ID: 29237752

5.Yamada S, Kugou K, Ding DQ, Fujita Y, Hiraoka Y, Murakami H, Ohta K, Yamada T.
The histone variant H2A.Z promotes initiation of meiotic recombination in fission yeast.
Nucleic Acids Res. , 2017 Nov 14. doi: 10.1093/nar/gkx1110.
Pubmed ID: 29145618

6.Iwamoto M, Hiraoka Y, Haraguchi T.

Newly found Tetrahymena nucleoporins, Nup214, Nup153 and Pom121/Pom82, differentiate nuclear pore complexes of functionally distinct nuclei.

Commun Integrat Biol. , 2017, Nov 03

(web: http://www.tandfonline.com/doi/full/10.1080/19420889.2017.1384890)

7.Yang HJ, Iwamoto M, Hiraoka Y, Haraguchi T.

Function of nuclear membrane proteins in shaping the nuclear envelope integrity during closed mitosis.

J Biochem. , 161(6):471-477 doi:10.1093/jb/mvx020.

Pubmed ID: 28398483

8.Iwamoto M, Osakada H, Mori C, Fukuda Y, Nagao K, Obuse C, Hiraoka Y, Haraguchi T.

Compositionally distinct nuclear pore complexes of functionally distinct dimorphic nuclei in ciliate Tetrahymena.

J. Cell Sci.,2017

Pubmed ID: 28386019

9.Chikashige Y, Yamane M, Okamasa K, Osakada H, Tsutsumi C, Nagahama Y, Fukuta N, Haraguchi T, Hiraoka Y.

Fission yeast APC/C activators Slp1 and Fzr1 sequentially trigger two consecutive nuclear divisions during meiosis.

FEBS Lett.,2017 Feb 28.

Pubmed ID: 28245054　責任著者

10. Yang HJ, Osakada H, Kojidani T, Haraguchi T, Hiraoka Y.
Lipid droplet dynamics during Schizosaccharomyces pombe sporulation and their role in spore survival.

Biol Open.,2017 Jan 3. pii: bio.022384.

Pubmed ID: 28011631

11. Hirai Y, Hirano Y, Matsuda A, Hiraoka Y, Honda T, Tomonaga K
Borna Disease Virus Assembles Porous Cage-like Viral Factories in the Nucleus.

J Biol Chem. ,2016

Pubmed ID: 27803166

12. Koyama M, Nagakura W, Tanaka H, Kujirai T, Chikashige Y, Haraguchi T, Hiraoka Y, Kurumizaka H.

In vitro reconstitution and biochemical analyses of the Schizosaccharomyces pombe nucleosome.

Biochem Biophys Res Commun. , 2016

Pubmed ID: 27890612 　

13. Matsuda A, Asakawa H, Haraguchi T, Hiraoka Y.

Spatial organization of the Schizosaccharomyces pombe genome within the nucleus.

Yeast.,2016 Oct 21.

Pubmed ID: 27766670　

14. Rong M1, Matsuda A, Hiraoka Y, Lee J.

Meiotic cohesin subunits RAD21L and REC8 are positioned at distinct regions between lateral elements and transverse filaments in the synaptonemal complex of mouse spermatocytes.

J Reprod Dev.,2016 Sep 26.

Pubmed ID: 27665783

15. Sato Y, Kujirai T, Arai R, Asakawa H, Ohtsuki C, Horikoshi N, Yamagata K, Ueda J, Nagase T, Haraguchi T, Hiraoka Y, Kimura A, Kurumizaka H, Kimura H.

A Genetically Encoded Probe for Live-Cell Imaging of H4K20 Monomethylation.

J Mol Biol. , Oct 9;428(20):3885-3902.

Pubmed ID: 27534817 　

16. Gómez-Saldivar G, Fernandez A, Hirano Y, Mauro M, Lai A, Ayuso C, Haraguchi T, Hiraoka Y, Piano F, Askjaer P.
Identification of Conserved MEL-28/ELYS Domains with Essential Roles in Nuclear Assembly and Chromosome Segregation

PLoS Genet, 2016

Pubmed ID: 27341616

17. Tange Y, Chikashige Y, Takahata S, Kawakami K, Higashi M, Mori C, Kojidani T, Hirano Y, Asakawa H, Murakami Y, Haraguchi T, Hiraoka Y.

Inner nuclear membrane protein Lem2 augments heterochromatin formation in response to nutritional conditions

Genes Cells, 2016 Aug;21(8):812-32.

Pubmed ID: 27334362

18. Tsuchiya M, Ogawa H, Koujin T, Kobayashi S, Mori C, Hiraoka Y, Haraguchi T.
Depletion of autophagy receptor p62/SQSTM1 enhances the efficiency of gene delivery in mammalian cells

FEBS Lett, 2016 Aug;590(16):2671-80.

Pubmed ID: 27317902

19. Iwamoto, M., Hiraoka, Y., Haraguchi, T.

Uniquely designed nuclear structures of lower eukaryotes

Current Opinion in Cell Biology, 2016

(web: http://www.sciencedirect.com/science/article/pii/S0955067416300266#)

20. Ding, D. Q., Haraguchi, T., and Hiraoka, Y.

A cohesin-based structural platform supporting homologous chromosome pairing in meiosis

Curr Genet, 2016

Pubmed ID: 26856595

21. Tashiro, S., Handa, T., Matsuda, A., Ban, T., Takigawa, T., Miyasato, K., Ishii, K., Kugou, K., Ohta, K., Hiraoka, Y., Masukata, H., and Kanoh, J.

Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing

Nat Commun 7, 10393, 2016

Pubmed ID: 26804021

22. Suzuki, S., Kato, H., Suzuki, Y., Chikashige, Y., Hiraoka, Y., Kimura, H., Nagao, K., Obuse, C., Takahata, S., and Murakami, Y.

Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast

Nucleic Acids Res, 2016

Pubmed ID: 26792892

23. Asakawa, H., Yang, H.-J., Hiraoka, Y., and Haraguchi, T.

Virtual nuclear envelope breakdown and its regulators in fission yeast meiosis

Front. Cell Dev. Biol, 2016

(web: http://journal.frontiersin.org/article/10.3389/fcell.2016.00005/abstract#)

24. Yang, H. J., Haraguchi, T., and Hiraoka, Y.

A nucleoporin that facilitates meiotic kinetochore reorganization

Cell Cycle, 2016

Pubmed ID: 26727711

Publication　2013～2015

1. Yamamoto, J., Oura, M., Yamashita, T., Miki, S., Jin, T., Haraguchi, T., Hiraoka, Y., Terai, H., and Kinjo, M.

Rotational diffusion measurements using polarization-dependent fluorescence correlation spectroscopy based on superconducting nanowire single-photon detector

Optics Express, 23, 32633-32642, 2015

Pubmed ID: 26699052

2. Ding, D. Q., Matsuda, A., Okamasa, K., Nagahama, Y., Haraguchi, T., and Hiraoka, Y.

Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe

Chromosoma, 2015

Pubmed ID: 26511279　

3. Asakawa, H., Yamamoto, T. G., and Hiraoka, Y.

Fission yeast meets a legend in Kobe: report of the Eighth International Fission Yeast Meeting

Genes Cells, 2015

Pubmed ID: 26477989　

4. Chikashige, Y., Arakawa, S., Leibnitz, K., Tsutsumi, C., Mori, C., Osakada, H., Murata, M., Haraguchi, T., and Hiraoka, Y.

Cellular economy in fission yeast cells continuously cultured with limited nitrogen resources

Sci Rep 5, 15617, 2015

Pubmed ID: 26486373　

5. Yang, H. J., Asakawa, H., Haraguchi, T., and Hiraoka, Y.

Nup132 modulates meiotic spindle attachment in fission yeast by regulating kinetochore assembly

J Cell Biol, 2015

Pubmed ID: 26483559　

6. Tsuchiya, M., Isogai, S., Taniguchi, H., Tochio, H., Shirakawa, M., Morohashi, K., Hiraoka, Y., Haraguchi, T., and Ogawa, H.

Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation

Sci Rep 5, 14498, 2015

Pubmed ID:26412716

7. Iwamoto, M., Hiraoka, Y., Haraguchi, T.

The nuclear pore complex acts as a master switch for nuclear differentiation

Commun Integr Biol 8:4, e1056950, 2015

Pubmed ID:26479399

8. Ruan, K., Yamamoto, T. G., Asakawa, H., Chikashige, Y., Kimura, H., Masukata, H., Haraguchi, T., and Hiraoka, Y.

Histone H4 acetylation required for chromatin decompaction during DNA replication

Sci Rep 5, 12720, 2015

Pubmed ID: 4520004　

9. Matsuda, A., Chikashige, Y., Ding, D. Q., Ohtsuki, C., Mori, C., Asakawa, H., Kimura, H., Haraguchi, T., and Hiraoka, Y.

Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast

Nat Commun 6, 7753, 2015

Pubmed ID: 26205977　

10. Poonperm, R., Takata, H., Hamano, T., Matsuda, A., Uchiyama, S., Hiraoka, Y., and Fukui, K.

Chromosome Scaffold is a Double-Stranded Assembly of Scaffold Proteins

Sci Rep 5, 11916, 2015

Pubmed ID: 4487240

11. Hirano, Y., Matsuda, A., and Hiraoka, Y.

Recent advancements in structured-illumination microscopy toward live-cell imaging

Microscopy (Oxf) 64, 237-249, 2015

Pubmed ID: 26133185　

12. Asakawa, H., Mori, C., Ohtsuki, C., Iwamoto, M. Hiraoka, Y., Haraguchi, T.

Uncleavable Nup98-Nup96 is functional in the fission yeast Schizosaccharomyces pombe

FEBS Open Bio 5, 508-14, 2015

Pubmed ID: 26137436

13. Kobayashi, S., Koujin, T., Kojidani, T., Osakada, H., Mori, C., Hiraoka, Y., and Haraguchi, T.

BAF is a cytosolic DNA sensor that leads to exogenous DNA avoiding autophagy

Proc Natl Acad Sci U S A, 2015

Pubmed ID: 25991860

14. Ruan, K., Yamamoto, T. G., Asakawa, H., Chikashige, Y., Masukata, H., Haraguchi, T., and Hiraoka, Y.

Meiotic nuclear movements in fission yeast are regulated by the transcription factor Mei4 downstream of a Cds1-dependent replication checkpoint pathway

Genes Cells 20, 160-172, 2015

Pubmed ID: 25492408　

15. Iwamoto, M., Koujin, T., Osakada, H., Mori, C., Kojidani, T., Matsuda, A., Asakawa, H., Hiraoka, Y., and Haraguchi, T.

Biased assembly of the nuclear pore complex is required for somatic and germline nuclear differentiation in Tetrahymena

J Cell Sci 128, 1812-1823, 2015

Pubmed ID: 25788697

16. Yamashita, T., Liu, D., Miki, S., Yamamoto, J., Haraguchi, T., Kinjo, M., Hiraoka, Y., Wang, Z., and Terai, H.

Fluorescence correlation spectroscopy with visible-wavelength superconducting nanowire single-photon detector

Opt Express 22, 28783-28789, 2014

Pubmed ID: 25402117

17. Chikashige, Y., Yamane, M., Okamasa, K., Mori, C., Fukuta, N., Matsuda, A., Haraguchi, T., and Hiraoka, Y.

Chromosomes rein back the spindle pole body during horsetail movement in fission yeast meiosis

Cell Struct Funct 39, 93-100, 2014

Pubmed ID: 4954111　

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Publication 2016～2017

Publication 2013～2015

Publication　2013～2015