論文
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Koyama, H., Ito, A.M., Okumura, H., Otani, T., Nakamura, K., and Fujimori, T.
Cell position-based evaluation of mechanical features of cells in multicellular systems.
J Theor Biol. 604. doi: 10.1016/j.jtbi.2025.112070. (2025)
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Kong, W., Hara, M., Tokunaga, Y., Okumura, K., Hirano, Y., Miao, J., Takenoshita, Y., Hashimoto, M., Sasaki, H., Fujimori, T., Wakabayashi, Y., and Fukagawa T.
CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation.
Life Sci Alliance. 8(1):e202402927. doi: 10.26508/lsa.202402927. (2024)
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Koyama, H., Okumura, H., Otani, T., Ito, A.M., Nakamura, K., Kato, K., and Fujimori, T.
Effective mechanical potential of cell–cell interaction in tissues harboring cavity and in cell sheet toward morphogenesis.
Front. Cell Dev. Biol. 12:1414601. doi: 10.3389/fcell.2024.1414601. (2024)
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Sakurai, J., Oka, S., Higuchi, Y., Ohsawa, S., and Fujimori, T.
Effects of blastocyst elongation and implantation chamber formation on the alignment of the embryonic axis and uterine axis in mice.
Front. Cell Dev. Biol. 12:1421222. doi: 10.3389/fcell.2024.1421222. eCollection 2024. (2024)
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Nguyen, T. P., Otani, T.,Tsutsumi, M., Kinoshita, N., Fujiwara, S., Nemoto, T., Fujimori, T., and Furuse, M.
Tight junction membrane proteins regulate the mechanical resistance of the apical junctional complex.
J Cell Biol. 223(5):e202307104. doi: 10.1083/jcb.202307104. (2024)
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Koyama, H., Okumura, H., Ito, A.M., Nakamura, K., Otani, T., Kato, K., and Fujimori, T.
Effective mechanical potential of cell-cell interaction explains three-dimensional morphologies during early embryogenesis.
PLoS Comput Biol. 19(8):e1011306. doi: 10.1371/journal.pcbi.1011306. (2023)
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Toyooka, Y., Aoki, K., Usami, M.F., Oka, S., Kato, A., and Fujimori, T.
Generation of pulsatile ERK activity in mouse embryonic stem cells is regulated by Raf activity.
Sci Rep. 13(1):9465. doi: 10.1038/s41598-023-36424-6. (2023)
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Miyazaki, S., Otani, T., Sugihara, K., Fujimori, T., Furuse, M., and Miura, T.
Mechanism of interdigitation formation at apical boundary of MDCK cell.
iScience 26(5):106594. doi: 10.1016/j.isci.2023.106594. (2023)
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Takashima, Y., Yamamoto, S., Okuno, N., Hamashima, T., Dang, S.T., Tran, N.D., Okita, N., Miwa, F., Dang, T.C., Matsuo, M., Takao, K., Fujimori, T., Mori, H., Tobe, K., Noguchi, M., and Sasahara, M.
PDGF receptor signal mediates the contribution of Nestin-positive cell lineage to subcutaneous fat development.
Biochem. Biophys. Res. Commun. 658:27-35. doi: 10.1016/j.bbrc.2023.03.052 (2023)
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Koyama, H., Kishi, K., Mikoshiba, S., and Fujimori, T.
An ImageJ-based tool for three-dimensional registration between different types of microscopic images.
Dev Growth Differ. 65(1):65-74. doi: 10.1111/dgd.12835. (2023)
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Koyama, H., Suzuki, M., Yasue, N., Sasaki, H., Ueno, N., and Fujimori, T.
Differential Cellular Stiffness Contributes to Tissue Elongation on an Expanding Surface.
Front Cell Dev Biol. 10:864135. doi: 10.3389/fcell.2022.864135. (2022)
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Kinoshita, N., Yamamoto, T. S., Yasue, N., Takagi, C., Fujimori, T. and Ueno, N.
Force-dependent remodeling of cytoplasmic ZO-1 condensates contributes to cell-cell adhesion through enhancing tight junctions.
iScience 25(2):103846. doi: 10.1016/j.isci.2022.103846. (2022)
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Kishi, K., Koyama, H., Oka, S., Kato, A., Sato, M., and Fujimori, T.
Repetitive short-pulsed illumination efficiently activates photoactivatable-Cre as continuous illumination in embryonic stem cells and pre-implantation embryos of transgenic mouse.
Genesis 59(12):e23457. doi: 10.1002/dvg.23457. (2021)
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Saito, H., Usami, M.F., Fujimori, T., Kimura, T., Ide, T., Yamamoto, T., Shibata, T., Onoue, K., Okayama, S., Yonemura, S., Misaki, k., Soba, Y., Kakui, Y., Sato, M., Toya, M., and Takeichi, M.
Tracheal motile cilia in mice require CAMSAP3 for the formation of central microtubule pair and coordinated beating.
Mol Biol Cell 32(20):ar12. doi: 10.1091/mbc.E21-06-0303. (2021)
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Hirata, T., Tohsato, Y., Itoga, H., Shioi, G., Kiyonari, H., Oka, S., Fujimori, T., and Onami, S.
NeuroGT: A brain atlas of neurogenic tagging CreER drivers for birthdate-based classification and manipulation of mouse neurons.
Cell Rep Methods 1(3):100012. doi: 10.1016/j.crmeth.2021.100012. (2021)
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Usami, M.F., Arata, M., Shi, D., Oka, S., Higuchi, Y., Tissir, F., Takeichi, M., and Fujimori, T.
Intercellular and intracellular cilia orientation is coordinated by CELSR1 and CAMSAP3 in oviduct multi-ciliated cells.
J Cell Sci. 134(4):jcs257006. doi: 10.1242/jcs.257006. (2021)
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Nguyen, Q.L., Okuno, N., Hamashima, T., Dang, S.T., Fujikawa, M., Ishii, Y., Enomoto, A., Maki, T., Nguyen, H.N., Nguyen, V.T., Fujimori, T., Mori, H., Andrae, J., Betsholtz, C., Takao, K., Yamamoto, S., and
Sasahara, M.
Vascular PDGFR-alpha protects against BBB dysfunction after stroke in mice.
Angiogenesis 24(1):35-46. doi: 10.1007/s10456-020-09742-w. (2021)
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Matsumoto, Y., Yamaguchi, Y., Hamachi, M., Nonomura, K., Muramatsu, Y., Yoshida, H., and Miura, M.
Apoptosis is involved in maintaining the character of the midbrain and the diencephalon roof plate after neural tube closure.
Dev. Biol. 468(1-2):101-109. doi: 10.1016/j.ydbio.2020.09.015. (2020)
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Sakai, Y., Kato, K., Koyama, H., Kuba, A., Takahashi, H., Fujimori, T., Hatta, M., Negri, A.P., Baird, A.H., and Ueno N.
A step-down photophobic response in coral larvae: implications for the light-dependent distribution of the common reef coral, Acropora tenuis.
Sci Rep. 10(1):17680. doi: 10.1038/s41598-020-74649-x. (2020)
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Hamashima, T., Ishii, Y., Nguyen, L.Q., Okuno, N., Sang, Y., Matushima, T., Kurashige, Y., Takebayashi, H., Mori, H., Fujimori, T., Yamamoto, S., and Sasahara, M.
Oligodendrogenesis and myelin formation in the forebrain require platelet-derived growth factor receptor-alpha.
Neuroscience. 436:11-26. doi: 10.1016/j.neuroscience.2020.04.001. (2020)
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Koyama, H., and Fujimori, T.
Isotropic expansion of external environment induces tissue elongation and collective cell alignment.
J Theor Biol. 496:110248. doi: 10.1016/j.jtbi.2020.110248. (2020)
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Kawasoe, R., Shinoda, T., Hattori, Y., Nakagawa, M., Pham, T.Q., Tanaka, Y., Sagou, K., Saito, K., Katsuki, S., Kotani, T., Sano, A., Fujimori, T., and Miyata, T.
Two-photon microscopic observation of cell-production dynamics in the developing mammalian neocortex in utero.
Dev Growth Differ. 62(2):118-128. doi: 10.1111/dgd.12648. (2020)
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Honda, H., Abe, T., and Fujimori, T.
The Chiral Looping of the Embryonic Heart Is Formed by the Combination of Three Axial Asymmetries.
Biophys J. 118(3):742-752. doi: 10.1016/j.bpj.2019.11.3397. (2020)
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Đặng, T.C., Ishii, Y., Nguyen, V.D., Yamamoto, S., Hamashima, T., Okuno, N., Nguyen, Q.L., Sang, Y., Ohkawa, N., Saitoh, Y., Shehata, M., Takakura, N., Fujimori, T., Inokuchi, K., Mori, H., Andrae, J., Betsholtz, C., and Sasahara, M.
Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFRα in Adult Brain.
Cell Rep. 27(4):1073-1089.e5. doi: 10.1016/j.celrep.2019.03.084. (2019)
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Kiyonari, H., Kaneko, M., Abe, T., Shioi, G., Aizawa, S., Furuta, Y., and Fujimori, T.
Dynamic organelle localization and cytoskeletal reorganization during preimplantation mouse embryo development revealed by live imaging of genetically encoded fluorescent fusion proteins.
Genesis 57(2):e23277. doi: 10.1002/dvg.23277 (2019)
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Sone, E., Noshiro, D., Ikebuchi, Y., Nakagawa, M., Khan, M., Tamura, Y., Ikeda, M., Oki, M., Murali, R., Fujimori, T., Yoda, T., Honma, M., Suzuki, H., Ando, T., and Aoki, K.
The induction of RANKL molecule clustering could stimulate early osteoblast differentiation.
Biochem Biophys Res Commun. 509(2):435-440. doi: 10.1016/j.bbrc.2018.12.093. (2019)
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Kamemizu, C., and Fujimori, T.
Distinct dormancy progression depending on embryonic regions during mouse embryonic diapause.
Biol Reprod. 100(5):1204-1214. doi: 10.1093/biolre/ioz017. (2019)
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Yamada, K., Hamashima, T., Ishii, Y., Yamamoto, S., Okuno, N., Yoshida, N., Yamada, M., Huang, T.T., Shioda, N., Tomihara, K., Fujimori, T., Mori, H., Fukunaga, K., Noguchi, M., and Sasahara, M.
Different PDGF Receptor Dimers Drive Distinct Migration Modes of the Mouse Skin Fibroblast.
Cell Physiol Biochem. 51(3):1461-1479. doi: 10.1159/000495594. (2018)
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Nonomura, K., Lukacs, V., Sweet, D.T., Goddard, L.M., Kanie, A., Whitwam, T., Ranade, S.S., Fujimori, T., Kahn, M.L., and Patapoutian, A.
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation.
Proc Natl Acad Sci U S A. 115(50):12817-12822. doi: 10.1073/pnas.1817070115. (2018)
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Abe, T., Kutsuna, N., Kiyonari, H., Furuta, Y., and Fujimori, T.
ROSA26 reporter mouse lines and image analyses reveal distinct region-specific cell behaviors in the visceral endoderm.
Development 145(22):dev165852. doi: 10.1242/dev.165852. (2018)
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Kikuchi, K., Nakamura, A., Arata, M., Shi, D., Nakagawa, M., Tanaka, T., Uemura, T., Fujimori, T., Kikuchi, A., Uezu, A., Sakamoto, Y., and Nakanishi, H.
Map7/7D1 and Dvl form a feedback loop that facilitates microtubule remodeling and Wnt5a signaling.
EMBO Rep. 19(7):e45471. doi: 10.15252/embr.201745471. (2018)
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Xu, J., Mathur, J., Vessières, E., Hammack, S., Nonomura, K., Favre, J., Grimaud, L., Petrus, M., Francisco, A., Li, J., Lee, V., Xiang, F., Mainquist, J.K., Cahalan, S.M., Orth, A.P., Walker, J.R.,
Ma, S., Lukacs, V., Bordone, L., Bandell, M., Laffitte, B., Xu, Y., Chien, S., Henrion, D., and Patapoutian, A.
GPR68 Senses Flow and Is Essential for Vascular Physiology.
Cell 173(3):762–775.e16. doi: 10.1016/j.cell.2018.03.076. (2018)
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Liu, L., Suzuki, K., Chun, E., Murashima, A., Sato, Y., Nakagata, N., Fujimori, T., Yonemura, S., He, W., and Yamada, G.
Androgen Regulates Dimorphic F-Actin Assemblies in the Genital Organogenesis.
Sex Dev. 11(4):190-202. doi: 10.1159/000477452. (2017)
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Shioi, G., Hoshino, H., Abe, T., Kiyonari, H., Nakao, K., Meng, W., Furuta, Y., Fujimori, T., and Aizawa, S.
Apical constriction in distal visceral endoderm cells initiates global, collective cell rearrangement in embryonic visceral endoderm to form anterior visceral endoderm.
Dev Biol. 429(1):20-30. doi: 10.1016/j.ydbio.2017.07.004. (2017)
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Suzuki, M., Sato, M., Koyama, H., Hara, Y., Hayashi, K., Yasue, N., Imamura, H., and Fujimori, T.,
Nagai, T., Campbell, R.E., and Ueno, N.
Distinct intracellular Ca2+ dynamics regulate apical constriction and differentially contribute to neural tube closure.
Development 144(7):1307-1316. doi: 10.1242/dev.141952. (2017)
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Minegishi, K., Hashimoto, M., Ajima, R., Takaoka, K., Shinohara, K., Ikawa, Y., Nishimura, H., McMahon, A.P.,
Willert, K., Okada, Y., Sasaki, H., Shi, D., Fujimori, T., Ohtsuka, T., Igarashi, Y., Yamaguchi, T.P., Shimono, A.,
Shiratori, H., and Hamada, H.
A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.
Dev Cell. 40(5):439-452.e4. doi: 10.1016/j.devcel.2017.02.010. (2017)
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Koyama, H., Shi, D., Suzuki, M., Ueno, N., Uemura, T., and Fujimori, T.
Mechanical Regulation of Three-Dimensional Epithelial Fold Pattern Formation in the Mouse Oviduct.
Biophys J. 111(3):650-665. doi: 10.1016/j.bpj.2016.06.032. (2016)
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Shi, D., Usami, F., Komatsu, K., Oka, S., Abe, T., Uemura, T., and Fujimori, T.
Dynamics of planar cell polarity protein Vangl2 in the mouse oviduct epithelium.
Mech Dev. 141:78-89. doi: 10.1016/j.mod.2016.05.002. (2016)
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Takemoto, T., Abe, T., Kiyonari, H., Nakao, K., Furuta, Y., Suzuki, H., Takada, S., Fujimori, T., and Kondoh, H.
R26-WntVis reporter mice showing graded response to Wnt signal levels.
Genes Cells. 21(6):661-669. doi: 10.1111/gtc.12364. (2016)
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Toyooka, Y., Oka, S., and Fujimori, T.
Early preimplantation cells expressing Cdx2 exhibit plasticity of specification to TE and ICM lineages through positional changes.
Dev Biol. 411(1):50-60. doi: 10.1016/j.ydbio.2016.01.011. (2016)
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Komatsu, K., and Fujimori, T.
Multiple phases in regulation of Nanog expression during pre-implantation development.
Dev Growth Differ. 57(9):648-656. doi: 10.1111/dgd.12244. (2015)
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Horikawa, S., Ishii, Y., Hamashima, T., Yamamoto, S., Mori, H., Fujimori, T., Shen, J., Inoue, R., Nishizono, H., Itoh, H.,
Majima, M., Abraham, D., Miyawaki, T., and Sasahara, M.
PDGFRα plays a crucial role in connective tissue remodeling.
Sci Rep. 5:17948. doi: 10.1038/srep17948. (2015)
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Nakayama, S., Arima, K., Kawai, K., Mohri, K., Inui, C., Sugano, W., Koba, H., Tamada, K., Nakata, Y.J., Kishimoto, K., Arai-Shindo, M.,
Kojima, C., Matsumoto, T., Fujimori, T., Agata, K., and Funayama, N.
Dynamic Transport and Cementation of Skeletal Elements Build Up the Pole-and-Beam Structured Skeleton of Sponges.
Curr Biol. 25(19):2549-2554. doi: 10.1016/j.cub.2015.08.023. (2015)
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Reyes de Mochel, N.S., Luong, M., Chiang, M., Javier, A.L., Luu, E., Toshihiko, F., MacGregor, G.R., Cinquin, O., and Cho, K.W.Y.
BMP signaling is required for cell cleavage in preimplantation-mouse embryos.
Dev Biol. 397(1):45-55. doi: 10.1016/j.ydbio.2014.10.001. (2015)
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Nakagawa, S., Shimada, M., Yanaka, K., Mito, M., Arai, T., Takahashi, E., Fujita, Y., Fujimori, T., Standaert, L., Marine, J.C.,
and Hirose, T.
The lncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice.
Development 141(23):4618-4627. doi: 10.1242/dev.110544. (2014)
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Shi, D., Komatsu, K., Hirao, M., Toyooka, Y., Koyama, H., Tissir, F., Goffinet, A.M., Uemura, T.,
and Fujimori, T.
Celsr1 is required for the generation of polarity at multiple levels of the mouse oviduct.
Development 141(23):4558-4568. doi: 10.1242/dev.115659. (2014)
pubmed
journal
BOR誌に取り上げられました！
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Imuta, Y., Koyama, H., Shi, D., Eiraku, M., Fujimori, T., and Sasaki, H.
Mechanical control of notochord morphogenesis by extra-embryonic tissues in mouse embryos.
Mech Dev. 132:44-58. doi: 10.1016/j.mod.2014.01.004. (2014)
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Mouri, K., Nishino, Y., Arata, M., Shi, D., Horiuchi, S.Y., and Uemura, T.
A novel planar polarity gene pepsinogen-like regulates wingless expression in a posttranscriptional manner.
Dev Dyn. 243(6):791-799. doi: 10.1002/dvdy.24112. (2014)
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Ishino, Y., Hayashi, Y., Naruse, M., Tomita, K., Sanbo, M., Fuchigami, T., Fujiki, R., Hirose, K., Toyooka, Y., Fujimori, T.,
Ikenaka, K., and Hitoshi, S.
Bre1a, a histone H2B ubiquitin ligase, regulates the cell cycle and differentiation of neural precursor cells.
J Neurosci. 34(8):3067-3078. doi: 10.1523/JNEUROSCI.3832-13.2014. (2014)
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Okamoto, M., Namba, T., Shinoda, T., Kondo, T., Watanabe, T., Inoue, Y., Takeuchi, K., Enomoto, Y., Ota, K., Oda, K., Wada, Y.,
Sagou, K., Saito, K., Sakakibara, A., Kawaguchi, A., Nakajima, K., Adachi, T., Fujimori, T., Ueda, M., Hayashi, S., Kaibuchi, K.,
and Miyata, T.
TAG-1-assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding.
Nat Neurosci. 16(11):1556-1566. doi: 10.1038/nn.3525. (2013)
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Xu, G., Shen, J., Ishii, Y., Fukuchi, M., Dang, T.C., Zheng, Y., Hamashima, T., Fujimori, T., Tsuda, M., Funa, K.,
and Sasahara, M.
Functional analysis of platelet-derived growth factor receptor-β in neural stem/progenitor cells.
Neuroscience 238:195-208. doi: 10.1016/j.neuroscience.2013.02.021. (2013)
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Abe, T., Sakaue-Sawano, A., Kiyonari, H., Shioi, G., Inoue, K., Horiuchi, T., Nakao, K., Miyawaki, A., Aizawa, S.,
and Fujimori, T.
Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter.
Development 140(1):237-246. doi: 10.1242/dev.084111. (2013)
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Bashar, M.K., Komatsu, K., Fujimori, T., and Kobayashi, T.J.
Automatic extraction of nuclei centroids of mouse embryonic cells from fluorescence microscopy images.
PLoS One 7(5):e35550. doi: 10.1371/journal.pone.0035550. (2012)
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Cao, L., Kobayakawa, S., Yoshiki, A., and Abe, K.
High resolution intravital imaging of subcellular structures of mouse abdominal organs using a microstage device.
PLoS One 7(3):e33876. doi: 10.1371/journal.pone.0033876. (2012)
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Koyama, H., Umeda, T., Nakamura, K., Higuchi, T., and Kimura, A.
A high-resolution shape fitting and simulation demonstrated equatorial cell surface softening during cytokinesis and
its promotive role in cytokinesis.
PLoS One 7(2):e31607. doi: 10.1371/journal.pone.0031607. (2012)
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Sato, Y., Iketani, M., Kurihara, Y., Yamaguchi, M., Yamashita, N., Nakamura, F., Arie, Y., Kawasaki, T., Hirata, T.,
Abe, T., Kiyonari, H., Strittmatter, S.M., Goshima, Y., and Takei, K.
Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation.
Science 333(6043):769-773. doi: 10.1126/science.1204144. (2011)
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Shioi, G., Kiyonari, H., Abe, T., Nakao, K., Fujimori, T., Jang, C.W., Huang, C.C., Akiyama, H., Behringer, R.R.,
and Aizawa, S.
A mouse reporter line to conditionally mark nuclei and cell membranes for in vivo live-imaging.
Genesis 49(7):570-578. doi: 10.1002/dvg.20758. (2011)
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Shi, D., Komatsu, K., Uemura, T., and Fujimori, T.
Analysis of ciliary beat frequency and ovum transport ability in the mouse oviduct.
Genes Cells. 16(3):282-290. doi: 10.1111/j.1365-2443.2011.01484.x. (2011)
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Nakagawa, T., Izumino, K., Ishii, Y., Oya, T., Hamashima, T., Jie, S., Ishizawa, S., Tomoda, F., Fujimori, T., Nabeshima, Y.,
Inoue, H., and Sasahara, M.
Roles of PDGF receptor-beta in the structure and function of postnatal kidney glomerulus.
Nephrol Dial Transplant. 26(2):458-468. doi: 10.1093/ndt/gfq468. (2011)
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Abe, T., Kiyonari, H., Shioi, G., Inoue, K., Nakao, K., Aizawa, S., and Fujimori, T.
Establishment of conditional reporter mouse lines at ROSA26 locus for live cell imaging.
Genesis 49(7):579-590. doi: 10.1002/dvg.20753. (2011)
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Zheng, L., Ishii, Y., Tokunaga, A., Hamashima, T., Shen, J., Zhao, QL., Ishizawa, S., Fujimori, T., Nabeshima, Y.,
Mori, H., Kondo, T., and Sasahara, M.
Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved.
J Neurosci Res. 88(6):1273-1284. doi: 10.1002/jnr.22302. (2010)
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Tissir, F., Qu, Y., Montcouquiol, M., Zhou, L., Komatsu, K., Shi, D., Fujimori, T., Labeau, J.,
Tyteca, D., Courtoy, P., Poumay, Y., Uemura, T., and Goffinet, A.M.
Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.
Nat Neurosci. 13(6):700-707. doi: 10.1038/nn.2555. (2010)
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Fujimori, T., Kurotaki, Y., Komatsu, K., and Nabeshima, Y.
Morphological organization of the mouse preimplantation embryo.
Reprod Sci. 16(2):171-177. doi: 10.1177/1933719108331120. (2009)
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Yuri, S., Fujimura, S., Nimura, K., Takeda, N., Toyooka, Y., Fujimura, Y., Aburatani, H., Ura, K., Koseki, H.,
Niwa, H., and Nishinakamura, R.
Sall4 is essential for stabilization, but not for pluripotency, of embryonic stem cells
by repressing aberrant trophectoderm gene expression.
Stem Cells 27(4):796-805. doi: 10.1002/stem.14. (2009)
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Tokunaga, A., Oya, T., Ishii, Y., Motomura, H., Nakamura, C., Ishizawa, S., Fujimori, T., Nabeshima, Y.,
Umezawa, A., Kanamori, M., Kimura, T., and Sasahara, M.
PDGF receptor beta is a potent regulator of mesenchymal stromal cell function.
J Bone Miner Res. 23(9):1519-1528. doi: 10.1359/jbmr.080409. (2008)
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Katsuno, T., Umeda, K., Matsui, T., Hata, M., Tamura, A., Itoh, M., Takeuchi, K., Fujimori, T., Nabeshima, Y.,
Noda, T., Tsukita, S., and Tsukita, S.
Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis
and apoptosis of embryonic cells.
Mol Biol Cell. 19(6):2465-2675. doi: 10.1091/mbc.e07-12-1215. (2008)
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Ishii, Y., Matsumoto, Y., Watanabe, R., Elmi, M., Fujimori, T., Nissen, J., Cao, Y., Nabeshima, Y., Sasahara, M., and Funa, K.
Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice.
Mol Cell Neurosci. 37(3):507-518. doi: 10.1016/j.mcn.2007.11.006. (2008)
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Toyooka, Y., Shimosato, D., Murakami, K., Takahashi, K., and Niwa, H.
Identification and characterization of subpopulations in undifferentiated ES cell culture.
Development 135(5):909-918. doi: 10.1242/dev.017400. (2008)
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Ohi, Y., Ishii, Y., Haji, A., Noguchi, S., Sasaoka, T., Fujimori, T., Nabeshima, Y., Sasahara, M., and Hattori, Y.
Platelet-derived growth factor (PDGF)-BB inhibits AMPA receptor-mediated synaptic transmission via PDGF receptor-beta
in murine nucleus tractus solitarius.
Brain Res. 1159:77-85. doi: 10.1016/j.brainres.2007.05.037. (2007)
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Kurotaki, Y., Hatta, K., Nakao, K., Nabeshima, Y., and Fujimori, T.
Blastocyst axis is specified independently of early cell lineage but aligns with the ZP shape.
Science 316(5825):719-723. doi: 10.1126/science.1138591. (2007)
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Imura, A., Tsuji, Y., Murata, M., Mareda, R., Kubota, K., Iwano, A., Obuse, C., Togashi, K., Tominaga, M., Kita, N.,
Tomiyama, K., Iijima, J., Nabeshima, Y., Fujioka, M., Asato, R., Tanaka, S., Kojima, K., Ito, J., Nozaki, K., Hashimoto, N.,
Ito, T., Nishio, T., Uchiyama, T., Fujimori, T., and Nabeshima, Y.
alpha-Klotho as a regulator of calcium homeostasis.
Science 316(5831):1615-1618. doi: 10.1126/science.1135901. (2007)
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Masui, S., Nakatake, Y., Toyooka, Y., Shimosato, D., Yagi, R., Takahashi, K., Okochi, H., Okuda, A., Matoba, R.,
Sharov, A.A., Ko, M.S.H., and Niwa, H.
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells.
Nat Cell Biol. 9(6):625-635. doi: 10.1038/ncb1589. (2007)
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Komatsu, K., Wakatsuki, S., Yamada, S., Yamamura, K., Miyazaki, J., and Sehara-Fujisawa, A.
Meltrin beta expressed in cardiac neural crest cells is required for ventricular septum formation of the heart.
Dev Biol. 2007; 303(1):82-92. doi: 10.1016/j.ydbio.2006.10.037. (2007)
2006
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Toyama, R., Fujimori, T., Nabeshima, Y., Itoh, Y., Tsuji, Y., Osamura, R.Y., and Nabeshima, Y.
Impaired regulation of gonadotropins leads to the atrophy of the female reproductive system in klotho-deficient mice.
Endocrinology 147(1):120-129. doi: 10.1210/en.2005-0429. (2006)
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Ishii, Y., Oya, T., Zheng, L., Gao, Z., Kawaguchi, M., Sabit, H., Matsushima, T., Tokunaga, A., Ishizawa, S., Hori, E.,
Nabeshima, Y., Sasaoka, T., Fujimori, T., Mori, H., and Sasahara, M.
Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury.
J Neurochem. 98(2):588-600. doi: 10.1111/j.1471-4159.2006.03922.x. (2006)
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Hiiragi, T., Alarcon, V.B., Fujimori, T., Louvet-Vallee, S., Maleszewski, M., Marikawa, Y., Maro, B., and Solter, D.
Where do we stand now? Mouse early embryo patterning meeting in Freiburg, Germany (2005).
Int J Dev Biol. 50(7):581-586; discussion 586-587. doi: 10.1387/ijdb.062181th. (2006)
2005
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Ito, S., Fujimori, T., Furuya, A., Satoh, J., Nabeshima, Y., and Nabeshima, Y.
Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho.
J Clin Invest. 115(8):2202-2208. doi: 10.1172/JCI23076. (2005)
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Gao, Z., Sasaoka, T., Fujimrori, T., Oya, T., Ishii, Y., Sabit, H., Kawaguchi, M., Kurotaki, Y., Naito, M., Wada, T.,
Ishizawa, S., Kobayashi, M., Nabeshima, Y., and Sasahara, M.
Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing.
J Biol Chem. 280(10):9375-9389. doi: 10.1074/jbc.M413081200. (2005)
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Niwa, H., Toyooka, Y., Shimosato, D., Strumpf, D., Takahashi, K., Yagi, R., and Rossant, J.
Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation.
Cell 123(5):917-929. doi: 10.1016/j.cell.2005.08.040. (2005)
-
Masui, S., Shimosato, D., Toyooka, Y., Yagi, R., Takahashi, K., and Niwa, H.
An efficient system to establish multiple embryonic stem cell lines carrying an inducible expression unit.
Nucleic Acids Res. 33(4):e43. doi: 10.1093/nar/gni043. (2005)
2004
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Tohyama, O., Imura, A., Iwano, A., Freund, J.N., Henrissat, B., Fujimori, T., and Nabeshima, Y.
Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides.
J Biol Chem. 279(11):9777-9784. doi: 10.1074/jbc.M312392200. (2004)
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Takeshita, K., Fujimori, T., Kurotaki, Y., Honjo, H., Tsujikawa, H., Yasui, K., Lee, J.K., Kamiya, K., Kitaichi, K.,
Yamamoto, K., Ito, M., Kondo, T., Iino, S., Inden, Y., Hirai, M., Murohara, T., Kodama, I., and Nabeshima, Y.
Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression.
Circulation 109(14):1776-1782. doi: 10.1161/01.CIR.0000124224.48962.32. (2004)
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Imura, A., Iwano, A., Tohyama, O., Tsuji, Y., Nozaki, K., Hashimoto, N., Fujimori, T., and Nabeshima, Y.
Secreted Klotho protein in sera and CSF: implication for post-translational cleavage
in release of Klotho protein from cell membrane.
FEBS Lett. 565(1-3):143-147. doi: 10.1016/j.febslet.2004.03.090. (2004)
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Kurohara, K., Komatsu, K., Kurisaki, T., Masuda, A., Irie, N., Asano, M., Sudo, K., Nabeshima, Y., Iwakura, Y.,
and Sehara-Fujisawa, A.
Essential roles of Meltrin beta (ADAM19) in heart development.
Dev Biol. 267(1):14-28. doi: 10.1016/j.ydbio.2003.10.021. (2004)
2003
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Tsujikawa, H., Kurotaki, Y., Fujimori, T., Fukuda, K., and Nabeshima, Y.
Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of
vitamin D endocrine system.
Mol Endocrinol. 17(12):2393-2403. doi: 10.1210/me.2003-0048. (2003)
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Seki, K., Fujimori, T., Savagner, P., Hata, A., Aikawa, T., Ogata, N., Nabeshima, Y., and Kaechoong, L.
Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan.
J Biol Chem. 278(43):41862-41870. doi: 10.1074/jbc.M308336200. (2003)
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Fujimori, T., Kurotaki, Y., Miyazaki, J., and Nabeshima, Y.
Analysis of cell lineage in two- and four-cell mouse embryos.
Development 130(21):5113-5122. doi: 10.1242/dev.00725. (2003)
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Toyooka, Y., Tsunekawa, N., Akasu, R., and Noce, T.
Embryonic stem cells can form germ cells in vitro.
Proc Natl Acad Sci U S A. 100(20):11457-11462. doi: 10.1073/pnas.1932826100. (2003)
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Komatsu, K., Manabe, N., Kiso, M., Shimabe, M., and Miyamoto, H.
Soluble Fas (FasB) regulates luteal cell apoptosis during luteolysis in murine ovaries.
Mol Reprod Dev. 65(4):345-352. doi: 10.1002/mrd.10312. (2003)
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Komatsu, K., Manabe, N., Kiso, M., Shimabe, M., and Miyamoto, H.
Changes in localization of immune cells and cytokines in corpora lutea during luteolysis in murine ovaries.
J Exp Zool A Comp Exp Biol. 296(2):152-159. doi: 10.1002/jez.a.10246. (2003)
2002
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Yoshida, T., Fujimori, T., and Nabeshima, Y.
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice
by increased expression of renal 1alpha-hydroxylase gene.
Endocrinology 143(2):683-689. doi: 10.1210/endo.143.2.8657. (2002)
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Ohbayashi, N., Shibayama, M., Kurotaki, Y., Imanishi, M., Fujimori, T., Itoh, N., and Takada, S.
FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis.
Genes Dev. 16(7):870-879. doi: 10.1101/gad.965702. (2002)
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Manya, H., Inomata, M., Fujimori, T., Dohmae, N., Sato, Y., Takio, K., Nabeshima, Y., and Endo, T.
Klotho protein deficiency leads to overactivation of mu-calpain.
J Biol Chem. 277(38):35503-35508. doi: 10.1074/jbc.M206033200. (2002)
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Ito, S., Fujimori, T., Hayashizaki, Y., and Nabeshima, Y.
Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure.
Biochim Biophys Acta. 1576(3):341-345. doi: 10.1016/s0167-4781(02)00281-6. (2002)
2001
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Koh, N., Fujimori, T., Nishiguchi, S., Tamori, A., Shiomi, S., Nakatani, T., Sugimura, K., Kishimoto, T.,
Kinoshita, S., Kuroki, T., and Nabeshima, Y.
Severely reduced production of klotho in human chronic renal failure kidney.
Biochem Biophys Res Commun. 280(4):1015-1020. doi: 10.1006/bbrc.2000.4226. (2001)
2000
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Kato, Y., Arakawa, E., Kinoshita, S., Shirai, A., Furuya, A., Yamano, K., Nakamura, K., Iida, A., Anazawa, H.,
Koh, N., Iwano, A., Imura, A., Fujimori, T., Kuro-o, M., Hanai, N., Takeshige, K., and Nabeshima, Y.
Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys.
Biochem Biophys Res Commun. 267(2):597-602. doi: 10.1006/bbrc.1999.2009. (2000)
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Ito, S., Kinoshita, S., Shiraishi, N., Nakagawa, S., Sekine, S., Fujimori, T., and Nabeshima, Y.I.
Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein.
Mech Dev. 98(1-2):115-119. doi: 10.1016/s0925-4773(00)00439-1. (2000)
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Tanaka, S.S., Toyooka, Y., Akasu, R., Katoh-Fukui, Y., Nakahara, Y., Suzuki, R., Yokoyama, M., and Noce, T.
The mouse homolog of Drosophila Vasa is required for the development of male germ cells.
Genes Dev. 14(7):841-853. doi: 10.1101/gad.14.7.841. (2000)
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Toyooka, Y., Tsunekawa, N., Takahashi, Y., Matsui, Y., Satoh, M., and Noce, T.
Expression and intracellular localization of mouse Vasa-homologue protein during germ cell development.
Mech Dev. 93(1-2):139-149. doi: 10.1016/s0925-4773(00)00283-5. (2000)
1998
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Toyooka, Y., Tanaka, S.S., Hirota, O., Tanaka, S., Takagi, N., Yamanouchi, K., Tojo, H., and Tachi, C.
Wilms' tumor suppressor gene (WT1) as a target gene of SRY function in a mouse ES cell line transfected with SRY.
Int J Dev Biol. 42(8):1143-51. (1998)
1997
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Yoshikawa, Y., Fujimori, T., McMahon, A.P., and Takada, S.
Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse.
Dev Biol. 183(2):234-242. doi: 10.1006/dbio.1997.8502. (1997)
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Ikebe, C., Ohashi, K., Fujimori, T., Bernard, O., Noda, T., Robertson, E.J., and Mizuno, K.
Mouse LIM-kinase 2 gene: cDNA cloning, genomic organization, and tissue-specific expression of two alternatively
initiated transcripts.
Genomics 46(3):504-508. doi: 10.1006/geno.1997.5060. (1997)
1995
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Amagai, M., Fujimori, T., Masunaga, T., Shimizu, H., Nishikawa, T., Shimizu, N., Takeichi, M., and Hashimoto, T.
Delayed assembly of desmosomes in keratinocytes with disrupted classic-cadherin-mediated cell adhesion
by a dominant negative mutant.
J Invest Dermatol. 104(1):27-32. doi: 10.1111/1523-1747.ep12613462. (1995)
1993
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Fujimori, T., and Takeichi, M.
Disruption of epithelial cell-cell adhesion by exogenous expression of a mutated nonfunctional N-cadherin.
Mol Biol Cell. 4(1):37-47. doi: 10.1091/mbc.4.1.37. (1993)
1992
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Takeichi, M., Hirano, S., Matsuyoshi, N., and Fujimori, T.
Cytoplasmic control of cadherin-mediated cell-cell adhesion.
Cold Spring Harb Symp Quant Biol. 57:327-334. doi: 10.1101/sqb.1992.057.01.037. (1992)
1990
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Takeichi, M., Inuzuka, H., Shimamura, K., Fujimori, T., and Nagafuchi, A.
Cadherin subclasses: differential expression and their roles in neural morphogenesis.
Cold Spring Harb Symp Quant Biol. 55:319-325. doi: 10.1101/sqb.1990.055.01.033. (1990)
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Fujimori, T., Miyatani, S., and Takeichi, M.
Ectopic expression of N-cadherin perturbs histogenesis in Xenopus embryos.
Development 110(1):97-104 doi: 10.1242/dev.110.1.97. (1990)
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