New Aspects of Gene Amplification
-Mechanisms and Biological Function-
Nov. 5 (Sat)-8(Tue), 2005 at Okazaki Conference Center,
National Institute for Basic Biology, Okazaki , 444-8585, Japan
Concept
Gene amplification not only results in genome alteration, it also plays wide-ranging
roles in many biological function. In multicellular organisms, it is observed
in many stages of the life-cycle, such as development, differentiation, senescence,
and tumorgensis. In unicellular organisms, it is one of the main strategies
for adaptation to the surroundings. Moreover, it is well-known that gene amplification
has played critical roles in evolution. Despite its involvement in these important
biological functions, gene amplification has not been a central focus for discussion.
One of the reasons is the mechanisms responsible have remained elusive. Now,
with the enormous increases in genomic information and the rapid progression
of DNA replication and recombination studies, we are in a good position to
look at new aspects of gene amplification. The aim of this symposium is to
discuss the molecular mechanisms and biological functions of gene amplification
(including maintenance mechanism of amplified genes) from several angles.
★ Molecular Mechanism of Gene Amplification
★ Adaptation and Gene Amplification
★ Evolution and Gene Amplification
Organizer:
Takehiko Kobayashi, Ph.D
Division of Genome Dynamics,
National Institute for Basic Biology