基礎生物学研究所　初期発生研究部門
National Institute for Basic Biology　 　Division of Embryology
大学院生歓迎します！
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業　績
 
　　論文 　　　総説 　　学会発表   
　　　　論 文
　２０１７
　 Suzuki M, Sato M, Koyama H, Hara Y, Hayashi K, Yasue N, Imamura H, Fujimori T,
Nagai T, Campbell RE, Ueno N.
Distinct intracellular Ca2+ dynamics regulate apical constriction and differentially contribute
to neural tube closure.
Development. 144:1307-1316. (2017)
　　　 pubmed 　　journal

　 Minegishi K, Hashimoto M, Ajima R, Takaoka K, Shinohara K, Ikawa Y, Nishimura H, McMahon AP,
Willert K, Okada Y, Sasaki H, Shi D, Fujimori T, Ohtsuka T, Igarashi Y, Yamaguchi TP,
Shimono A, Shiratori H, Hamada H.
A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells
for Left-Right Symmetry Breaking.
Dev Cell. 40:439-452. (2017)
　　　 pubmed 　　journal
　２０１６
　 Koyama H, Shi D, Suzuki M, Ueno N, Uemura T, Fujimori T.
Mechanical Regulation of Three-Dimensional Epithelial Fold Pattern Formation in the Mouse Oviduct.
Biophys J. 111:650-665. (2016)
　　　 pubmed 　　journal 　　論文が表紙になりました！

　 Shi D, Usami F, Komatsu K, Oka S, Abe T, Uemura T, Fujimori T.
Dynamics of planar cell polarity protein Vangl2 in the mouse oviduct epithelium.
Mech Dev. 141:78-89. (2016)
　　　 pubmed 　　journal

　 Takemoto T, Abe T, Kiyonari H, Nakao K, Furuta Y, Suzuki H, Takada S, Fujimori T, Kondoh H.
R26-WntVis reporter mice showing graded response to Wnt signal levels.
Genes Cells. 21:661-669. (2016)
　　　 pubmed 　　journal

　 Toyooka Y, Oka S, Fujimori T.
Early preimplantation cells expressing Cdx2 exhibit plasticity of specification to TE and ICM lineages
through positional changes.
Dev Biol. 411:50-60. (2016)
　　　 pubmed 　　journal
　２０１５
　 Komatsu K, Fujimori T.
Multiple phases in regulation of Nanog expression during pre-implantation development.
Dev Growth Differ. 57:648-656. (2015)
　　　 pubmed 　　journal 　　　 論文が表紙になりました！

　 Horikawa S, Ishii Y, Hamashima T, Yamamoto S, Mori H, Fujimori T, Shen J, Inoue R, Nishizono H,
Itoh H, Majima M, Abraham D, Miyawaki T, Sasahara M.
PDGFRα plays a crucial role in connective tissue remodeling.
Sci Rep. 5:17948. (2015)
　　　 pubmed 　　journal

　 Nakayama S, Arima K, Kawai K, Mohri K, Inui C, Sugano W, Koba H, Tamada K, Nakata YJ, Kishimoto K,
Arai-Shindo M, Kojima C, Matsumoto T, Fujimori T, Agata K, Funayama N.
Dynamic Transport and Cementation of Skeletal Elements Build Up the Pole-and-Beam Structured Skeleton
of Sponges.
Curr Biol. 25:2549-54. (2015)
　　　 pubmed 　　journal

　 Reyes de Mochel NS, Luong M, Chiang M, Javier AL, Luu E, Fujimori T, MacGregor GR, Cinquin O, Cho KW.
BMP signaling is required for cell cleavage in preimplantation-mouse embryos.
Dev. Biol. 397:45-55. (2015)
　　　 pubmed 　　journal
　２０１４
　 Nakagawa S, Shimada M, Yanaka K, Mito M, Arai T, Takahashi E, Fujita Y, Fujimori T, Standaert L, Marine JC,
Hirose T.
The lncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a
subpopulation of mice.
Development. 141:4618-27. (2014)
　　　 pubmed 　　journal

　 Shi D, Komatsu K, Hirao M, Toyooka Y, Koyama H, Tissir F, Goffinet AM, Uemura T, Fujimori T.
Celsr1 is required for the generation of polarity at multiple levels of the mouse oviduct.
Development. 141:4558-68. (2014)
　　　 pubmed 　　journal 　　　 論文が表紙になりました！ 　　　 BOR誌に取り上げられました！

　 Imuta Y, Koyama H, Shi D, Eiraku M, Fujimori T, Sasaki H.
Mechanical control of notochord morphogenesis by extra-embryonic tissues in mouse embryos.
Mech Dev. 132:44-58. (2014)
　　　 pubmed 　　journal

　 Mouri K, Nishino Y, Arata M, Shi D, Horiuchi S, Uemura T.
A novel planar polarity gene pepsinogen-like regulates wingless expression in a posttranscriptional manner.
Dev Dyn. 243:791-9. (2014)
　　　 pubmed 　　journal

　 Ishino Y, Hayashi Y, Naruse M, Tomita K, Sanbo M, Fuchigami T, Fujiki R, Hirose K, Toyooka Y, Fujimori T,
Ikenaka K, Hitoshi S.
Bre1a, a histone H2B ubiquitin ligase, regulates the cell cycle and differentiation of neural precursor cells.
J Neurosci. 34:3067-78. (2014)
　　　 pubmed 　　journal
　２０１３
　 Okamoto M, Namba T, Shinoda T, Kondo T, Watanabe T, Inoue Y, Takeuchi K, Enomoto Y, Ota K, Oda K,
Wada Y, Sagou K, Saito K, Sakakibara A, Kawaguchi A, Nakajima K, Adachi T, Fujimori T, Ueda M, Hayashi S,
Kaibuchi K, Miyata T.
TAG-1-assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding.
Nat Neurosci. 16:1556-66. (2013)
　　　 pubmed 　　journal

　 Shi D, Fujimori T, Uemura T.
Atypical cadherin negotiates a turn.
Dev Cell. 26:1-2. (2013)
　　　 pubmed 　　journal

　 Abe T, Fujimori T.
Reporter mouse lines for fluorescence imaging.
Dev Growth Differ. 55:390-405. (2013)
　　　 pubmed 　　journal

　 Xu G, Shen J, Ishii Y, Fukuchi M, Dang TC, Zheng Y, Hamashima T, Fujimori T, Tsuda M, Funa K, et al.
Functional analysis of platelet-derived growth factor receptor-beta in neural stem/progenitor cells.
Neuroscience. 238:195-208. (2013)
　　　 pubmed 　　journal

　 Abe T, Sakaue-Sawano A, Kiyonari H, Shioi G, Inoue K, Horiuchi T, Nakao K, Miyawaki A, Aizawa S,
Fujimori T.
Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter.
Development. 140:237-46. (2013)
　　　 pubmed 　　journal　

　 Abe T, Aizawa S, Fujimori T.
Live imaging of early mouse embryos using fluorescently labeled transgenic mice.
Methods Mol Biol. 1052:101-8. (2013)
　　　 pubmed 　　journal　
　２０１２
　 Bashar MK, Komatsu K, Fujimori T, Kobayashi TJ.
Automatic extraction of nuclei centroids of mouse embryonic cells from fluorescence microscopy images.
PLoS One. 7:e35550. (2012)
　　　 pubmed 　　journal

　 Cao L, Kobayakawa S, Yoshiki A, Abe K.
High resolution intravital imaging of subcellular structures of mouse abdominal organs using a microstage device.
PLoS One. 7:e33876. (2012)
　　　 pubmed 　　journal

　 Koyama H, Umeda T, Nakamura K, Higuchi T, Kimura A.
A high-resolution shape fitting and simulation demonstrated equatorial cell surface softening during cytokinesis
and its promotive role in cytokinesis.
PLoS One. 7:e31607. (2012)
　　　 pubmed 　　journal
　２０１１
　 Sato Y, Iketani M, Kurihara Y, Yamaguchi M, Yamashita N, Nakamura F, Arie Y, Kawasaki T, Hirata T, Abe T,
Kiyonari H, Strittmatter SM, Goshima Y, Takei K.
Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation.
Science. 333:769-73. (2011)
　　　 pubmed 　　journal

　 Shioi G, Kiyonari H, Abe T, Nakao K, Fujimori T, Jang CW, Huang CC, Akiyama H, Behringer RR. Aizawa S.
A mouse reporter line to conditionally mark nuclei and cell membranes for in vivo live-imaging.
Genesis. 49:570-8. (2011)
　　　 pubmed 　　journal

　 Shi D, Komatsu K, Uemura T, Fujimori T.
Analysis of ciliary beat frequency and ovum transport ability in the mouse oviduct.
Genes Cells. 16:282-90. (2011)
　　　 pubmed 　　journal

　 Nakagawa T, Izumino K, Ishii Y, Oya T, Hamashima T, Jie S, Ishizawa S, Tomoda F, Fujimori T,
Nabeshima Y, et al.
Roles of PDGF receptor-beta in the structure and function of postnatal kidney glomerulus.
Nephrol Dial Transplant. 26:458-68. (2011)
　　　 pubmed 　　journal

　 Abe T, Kiyonari H, Shioi G, Inoue K, Nakao K, Aizawa S, Fujimori T.
Establishment of conditional reporter mouse lines at ROSA26 locus for live cell imaging.
Genesis. 49:579-90. (2011)
　　　 pubmed 　　journal 　　　 論文が表紙になりました！
　２０１０
　 Zheng L, Ishii Y, Tokunaga A, Hamashima T, Shen J, Zhao QL, Ishizawa S, Fujimori T, Nabeshima Y,
Mori H, et al.
Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved.
J Neurosci Res. 88:1273-84. (2010)
　　　 pubmed 　　journal

　 Tissir F, Qu Y, Montcouquiol M, Zhou L, Komatsu K, Shi D, Fujimori T, Labeau J, Tyteca D, Courtoy P, et al.
Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus.
Nat Neurosci. 13:700-7. (2010)
　　　 pubmed 　　journal

　 Fujimori T.
Preimplantation development of mouse: a view from cellular behavior.
Dev Growth Differ. 52:253-262. (2010)
　　　 pubmed 　　journal
　２００９ 
　 Fujimori T, Kurotaki Y, Komatsu K, Nabeshima Y.
Morphological organization of the mouse preimplantation embryo.
Reprod Sci. 16:171-7. (2009)
　　　 pubmed 　　journal

　 Yuri S, Fujimura S, Nimura K, Takeda N, Toyooka Y, Fujimura Y, Aburatani H, Ura K, Koseki H, Niwa H,
Nishinakamura R.
Sall4 is essential for stabilization, but not for pluripotency, of embryonic stem cells by repressing aberrant
trophectoderm gene expression.
Stem Cells. 27:796-805. (2009)
　　　 pubmed 　　journal
　２００８
　 Tokunaga A, Oya T, Ishii Y, Motomura H, Nakamura C, Ishizawa S, Fujimori T, Nabeshima Y, Umezawa A,
Kanamori M, et al.
PDGF receptor beta is a potent regulator of mesenchymal stromal cell function.
J Bone Miner Res. 23:1519-28. (2008)
　　　 pubmed 　　journal

　 Katsuno T, Umeda K, Matsui T, Hata M, Tamura A, Itoh M, Takeuchi K, Fujimori T, Nabeshima Y, Noda T, et al.
Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac
angiogenesis and apoptosis of embryonic cells.
Mol Biol Cell. 19:2465-75. (2008)
　　　 pubmed 　　journal

　 Ishii Y, Matsumoto Y, Watanabe R, Elmi M, Fujimori T, Nissen J, Cao Y, Nabeshima Y, Sasahara M, Funa K.
Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone
of postnatal mice.
Mol Cell Neurosci. 37:507-18. (2008)
　　　 pubmed 　　journal

　 Toyooka Y, Shimosato D, Murakami K, Takahashi K, Niwa H.
Identification and characterization of subpopulations in undifferentiated ES cell culture.
Development. 135:909-18. (2008)
　　　 pubmed 　　journal
　　　２００７年以前　　　　
　２００７ 
　 Ohi Y, Ishii Y, Haji A, Noguchi S, Sasaoka T, Fujimori T, Nabeshima Y, Sasahara M, Hattori Y.
Platelet-derived growth factor (PDGF)-BB inhibits AMPA receptor-mediated synaptic transmission via PDGF
receptor-beta in murine nucleus tractus solitarius.
Brain Res. 1159:77-85. (2007)
　　　 pubmed 　　journal

　 Kurotaki Y, Hatta K, Nakao K, Nabeshima Y, Fujimori T.
Blastocyst axis is specified independently of early cell lineage but aligns with the ZP shape.
Science. 316:719-23. (2007)
　　　 pubmed 　　journal 　　comment

　 Imura A, Tsuji Y, Murata M, Maeda R, Kubota K, Iwano A, Obuse C, Togashi K, Tominaga M, Kita N, et al.
alpha-Klotho as a regulator of calcium homeostasis.
Science. 316:1615-8. (2007)
　　　 pubmed 　　journal

　 Masui S, Nakatake Y, Toyooka Y, Shimosato D, Yagi R, Takahashi K, Okochi H, Okuda A, Matoba R,
Sharov AA, Ko MS, Niwa H.
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouseembryonic stem cells.
Nat Cell Biol. 9:625-35. (2007)
　　　 pubmed 　　journal

　 Komatsu K, Wakatsuki S, Yamada S, Yamamura K, Miyazaki J, Sehara-Fujisawa A.
Meltrin beta expressed in cardiac neural crest cells is required for ventricular septum formation of the heart.
Dev Biol. 303:82-92. (2007)
　　　 pubmed 　　journal
　２００６ 
　 Toyama R, Fujimori T, Nabeshima Y, Itoh Y, Tsuji Y, Osamura RY, Nabeshima Y.
Impaired regulation of gonadotropins leads to the atrophy of the female reproductive system in klotho-deficient
mice.
Endocrinology. 147:120-9. (2006)
　　　 pubmed 　　journal

　 Ishii Y, Oya T, Zheng L, Gao Z, Kawaguchi M, Sabit H, Matsushima T, Tokunaga A, Ishizawa S, Hori E, et al.
Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury.
J Neurochem. 98:588-600. (2006)
　　　 pubmed 　　journal

　 Hiiragi T, Alarcon VB, Fujimori T, Louvet-Vallee S, Maleszewski M, Marikawa Y, Maro B, Solter D.
Where do we stand now? Mouse early embryo patterning meeting in Freiburg, Germany (2005).
Int J Dev Biol. 50:581-6; discussion 586-7. (2006)
　　　 pubmed 　　journal
　２００５ 
　 Ito S, Fujimori T, Furuya A, Satoh J, Nabeshima Y, Nabeshima Y.
Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho.
J Clin Invest. 115:2202-8. (2005)
　　　 pubmed 　　journal

　 Gao Z, Sasaoka T, Fujimori T, Oya T, Ishii Y, Sabit H, Kawaguchi M, Kurotaki Y, Naito M, Wada T, et al.
Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing.
J Biol Chem. 280:9375-89. (2005)
　　　 pubmed 　　journal

　 Niwa H, Toyooka Y, Shimosato D, Strumpf D, Takahashi K, Yagi R, Rossant J.
Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation.
Cell. 123:917-29. (2005)
　　　 pubmed 　　journal

　 Masui S, Shimosato D, Toyooka Y, Yagi R, Takahashi K, Niwa H.
An efficient system to establish multiple embryonic stem cell lines carrying an inducible expression unit.
Nucleic Acids Res. 33:e43. (2005)
　　　 pubmed 　　journal
　２００４ 
　 Tohyama O, Imura A, Iwano A, Freund JN, Henrissat B, Fujimori T, Nabeshima Y.
Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides.
J Biol Chem. 279:9777-84. (2004)
　　　 pubmed 　　journal

　 Takeshita K, Fujimori T, Kurotaki Y, Honjo H, Tsujikawa H, Yasui K, Lee JK, Kamiya K, Kitaichi K,
Yamamoto K, et al.
Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression.
Circulation. 109:1776-82. (2004)
　　　 pubmed 　　journal

　 Imura A, Iwano A, Tohyama O, Tsuji Y, Nozaki K, Hashimoto N, Fujimori T, Nabeshima Y.
Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein
from cell membrane.
FEBS Lett. 565:143-7. (2004)
　　　 pubmed 　　journal

　 Kurohara K, Komatsu K, Kurisaki T, Masuda A, Irie N, Asano M, Sudo K, Nabeshima Y, Iwakura Y,
Sehara-Fujisawa A.
Essential roles of Meltrinβ(ADAM19) in heart development.
Dev Biol. 267:14-28. (2004)
　　　 pubmed 　　journal
　２００３ 
　 Tsujikawa H, Kurotaki Y, Fujimori T, Fukuda K, Nabeshima Y.
Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory
circuit of vitamin D endocrine system.
Mol Endocrinol. 17:2393-403. (2003)
　　　 pubmed 　　journal

　 Seki K, Fujimori T, Savagner P, Hata A, Aikawa T, Ogata N, Nabeshima Y, Kaechoong L.
Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and
aggrecan.
J Biol Chem. 278:41862-70. (2003)
　　　 pubmed 　　journal

　 Fujimori T, Kurotaki Y, Miyazaki J, Nabeshima Y.
Analysis of cell lineage in two- and four-cell mouse embryos.
Development. 130:5113-22. (2003)
　　　 pubmed 　　journal

　 Toyooka Y, Tsunekawa N, Akasu R, Noce T.
Embryonic stem cells can form germ cells in vitro.
Proc Natl Acad Sci U S A. 100:11457-62. (2003)
　　　 pubmed 　　journal

　 Komatsu k, Manabe N, Kiso M, Shimabe M, Miyamoto H.
Soluble Fas (FasB) regulates luteal cell apoptosis during luteolysis in murine ovaries.
Mol Reprod Dev. 65:345-52. (2003)
　　　 pubmed 　　journal

　 Komatsu K, Manabe N, Kiso M, Shimabe M, Miyamoto H.
Change in localization of immune cells and cytokines in corpora lutea during luteolysis in murine ovaries.
J Exp Zool A Comp Exp Biol. 296:152-9. (2003)
　　　 pubmed 　　journal
　２００２ 
　 Yoshida T, Fujimori T, Nabeshima Y.
Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by
increased expression of renal 1alpha-hydroxylase gene.
Endocrinology. 143:683-9. (2002)
　　　 pubmed 　　journal

　 Ohbayashi N, Shibayama M, Kurotaki Y, Imanishi M, Fujimori T, Itoh N, Takada S.
FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis.
Genes Dev. 16:870-9. (2002)
　　　 pubmed 　　journal

　 Manya H, Inomata M, Fujimori T, Dohmae N, Sato Y, Takio K, Nabeshima Y, Endo T.
Klotho protein deficiency leads to overactivation of mu-calpain.
J Biol Chem. 277:5503-8. (2002)
　　　 pubmed 　　journal

　 Ito S, Fujimori T, Hayashizaki Y, Nabeshima Y.
Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical
active site structure.
Biochim Biophys Acta. 1576:341-5. (2002)
　　　 pubmed 　　journal
　２００１ 
　 Koh N, Fujimori T, Nishiguchi S, Tamori A, Shiomi S, Nakatani T, Sugimura K, Kishimoto T, Kinoshita S,
Kuroki T, et al.
Severely reduced production of klotho in human chronic renal failure kidney.
Biochem Biophys Res Commun. 280:1015-20. (2001)
　　　 pubmed 　　journal
　２０００ 
　 Kato Y, Arakawa E, Kinoshita S, Shirai A, Furuya A, Yamano K, Nakamura K, Iida A, Anazawa H, Koh N, et al.
Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys.
Biochem Biophys Res Commun. 267:597-602. (2000)
　　　 pubmed 　　journal

　 Ito S, Kinoshita S, Shiraishi N, Nakagawa S, Sekine S, Fujimori T, Nabeshima YI.
Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein.
Mech Dev. 98:115-9. (2000)
　　　 pubmed 　　journal

　 Tanaka SS, Toyooka Y, Akasu R, Katoh-Fukui Y, Nakahara Y, Suzuki R, Yokoyama M, Noce T.
The mouse homolog of Drosophila Vasa is required for the development of male germ cells.
Genes Dev. 14:841-53. (2000)
　　　 pubmed 　　journal

　 Toyooka Y, Tsunekawa N, Takahashi Y, Matsui Y, Satoh M, Noce T.
Expression and intracellular localization of mouse Vasa-homologue protein during germ cell development.
Mech Dev. 93:139-49. (2000)
　　　 pubmed 　　journal
　１９９８ 
　 Toyooka Y, Tanaka SS, Hirota O, Tanaka S, Takagi N, Yamanouchi K, Tojo H, Tachi C.
Wilms' tumor suppressor gene (WT1) as a target gene of SRY function in a mouse ES cell line transfected
with SRY.
Int J Dev Biol. 42:1143-51. (1998)
　　　 pubmed 　　journal
　１９９７ 
　 Yoshikawa Y, Fujimori T, McMahon AP, Takada S.
Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development
in the mouse.
Dev Biol. 183:234-42. (1997)
　　　 pubmed 　　journal

　 Ikebe C, Ohashi K, Fujimori T, Bernard O, Noda T, Robertson EJ, Mizuno K.
Mouse LIM-kinase 2 gene: cDNA cloning, genomic organization, and tissue-specific expression of two
alternatively initiated transcripts.
Genomics. 46:504-8. (1997)
　　　 pubmed 　　journal
　１９９５ 
　 Amagai M, Fujimori T, Masunaga T, Shimizu H, Nishikawa T, Shimizu N, Takeichi M, Hashimoto T.
Delayed assembly of desmosomes in keratinocytes with disrupted classic-cadherin-mediated cell adhesion
by a dominant negative mutant.
J Invest Dermatol. 104:27-32. (1995)
　　　 pubmed 　　journal
　１９９３ 
　 Fujimori T, Takeichi M.
Disruption of epithelial cell-cell adhesion by exogenous expression of a mutated nonfunctional N-cadherin.
Mol Biol Cell. 4:37-47. (1993)
　　　 pubmed 　　journal
　１９９２ 
　 Takeichi M, Hirano S, Matsuyoshi N, Fujimori T.
Cytoplasmic control of cadherin-mediated cell-cell adhesion.
Cold Spring Harb Symp Quant Biol. 57:327-34. (1992)
　　　 pubmed 　　journal
　１９９０ 
　 Takeichi M, Inuzuka H, Shimamura K, Fujimori T, Nagafuchi A.
Cadherin subclasses: differential expression and their roles in neural morphogenesis.
Cold Spring Harb Symp Quant Biol. 55:319-25. (1990)
　　　 pubmed 　　journal

　 Fujimori T, Miyatani S, Takeichi M.
Ectopic expression of N-cadherin perturbs histogenesis in Xenopus embryos.
Development. 110:97-104. (1990)
　　　 pubmed 　　journal
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