基礎生物学研究所・神経行動学研究部門

研究業績

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原著論文

  • Kawano, K., Kato, K., Sugioka, T., Kimura, Y., Tanimoto, M., and Higashijima, S. (2022). Long descending commissural V0v neurons ensure coordinated swimming movements along the body axis in larval zebrafish. Scientific Reports 12, 4348.
  • Bohem, U.L., Kimura, Y., Kawashima, T., Ahrens, M., Higashijima, S., Engert, F., and Cohen, A. (2022). Voltage imaging identifies spinal circuits that modulate locomotor adaptation in zebrafish. Neuron 110, 1-12.
  • Suzuki, D., Wada, H., and Higashijima, S. (2021). Generation of knock-in lampreys by CRISPR-Cas9-mediated genome engineering. Scientific Reports 11, 19836.
  • Liu, Z., Kimura Y., Higashijima, S. Hildebrand, D.G., Morgan, J.L., Holy, T.E., and Bagnall, M.W. (2020). Central vestibular tuning arises from patterned convergence of otolith afferents. Neuron, 108, 1-15.
  • Mizoguchi, T., Fukada, M., Iihama, M., Song, X., Fukagawa, S., Kuwabara, S., Omaru, S., Higashijima, S., and Itoh, M. (2020). Transient activation of the Notch-her15.1 axis plays an important role in the maturation of V2b. Development 147, 131912.
  • Uemura, Y., Kato, K., Kawakami, K., Kimura, Y., Oda, Y. and Higashijima, S. (2020). Neuronal circuits that control rhythmic pectoral fin movements in zebrafish. Journal of Neuroscience, 40, 6678-6690.
  • Satou, C., Sugioka, T., Uemura, Y., Shimazaki, T., Zmarz, P., Kimura, Y., and Higashijima, S. (2020). Functional diversity of glycinergic commissural inhibitory neurons in larval zebrafish. Cell Reports, 30, 3036-3050.
  • Callahan, R.A., Roberts, R., Sengupta, M., Kimura, Y., Higashijima, S., and Bagnall, M.W. (2019). Spinal V2b neurons reveal a role for ipsilateral inhibition in speed control. eLife 8, Article# e47837.
  • Frank, T., Moenig, N.R., Satou, C., Higashijima, S. and Friedrich, R.W. (2019). Associative conditioning remaps odor representations and modifies inhibition in a higher olfactory brain area. Nature Neuroscience 11, 1844-1856.
  • Kimura, Y. and Higashijima, S. (2019). Regulation of locomotor speed and selection of active sets of neurons by V1 neurons. Nature Communications 10, Article# 2268.
  • Shimazaki, T., Tanimoto, M., Oda, Y., and Higashijima, S. (2019). Behavioral role of the reciprocal inhibition between a pair of Mauthner cells during fast escapes in zebrafish. Journal of Neuroscience 39, 1182-1194.
  • Watakabe, I.,Hashimoto, H., Kimura, Y., Yokoi, S., Naruse, K., and Higashijima, S. (2018). Highly efficient generation of knock-in transgenic medaka by CRISPR/Cas9-mediated genome engineering. Zoological Letters 4, Article 3.
  • Taniguchi, A., Kimura, Y., Mori, I., Nonaka, S., and Higashijima, S. (2017). Axially-confined in vivo single-cell labeling by primed conversion using blue and red lasers with conventional confocal microscopes. Development, Growth & Differentiation 59, 741-748.
  • Ratanayotha, A., Kawai, T., Higashijima, S., and Okamura, Y. (2017). Molecular and Functional Characterization of the Voltage-Gated Proton Channel in Zebrafish Neutrophils. Physiological Reports 15, e13345
  • Chou, M-Y., Amo, R., Kinoshita, M., Cherng, B-W., Shimazaki, H., Agetsuma, M., Shiraki, T., Aoki, T., Yamazaki, M., Higashijima, S., and Okamoto, H. (2016). Social conflict resolution regulated by two dorsal habenular subregions in zebrafish. Science 352, 87-90.
  • Kawamura, A., Ovara, H., Ooka, Y., Kinoshita, H., Hoshikawa, M., Nakajo, K., Yokota, D., Jujino, Y., Higashijima, S., Takada, S., and Yamasu, K. (2016). Posterior-anterior gradient of zebrafish hes6 expression in the presomitic mesoderm is established by the combinatorial functions of the downstream enhancer and 3'UTR. Developmental Biology 409, 543-554.
  • Marquart, G.D., Tabor, K.M., Brown, M.R., Strykowski, J.L., LaFave, M.C., Varshney, G.K., Mueller, T., Burgess, S.M., Higashijima, S., and Burgess, H.A. (2015). A 3d-searchable database of transgenic zebrafish Gal4 and Cre lines for functional neuroanatomy studies. Frontiers in Neural Circuits 9, Article 78.
  • Amo, R., Fredes, F. Kinoshita, M., Aoki, R., Aizawa, H., Agetsuma, M., Aoki, T., Shiraki, T., Kakinuma, H., Matsuda, M., Yamazaki, M., Takahoko, M., Tsuboi, T., Higashijima, S., Miyasaka, N., Koide, T., Yabuki, Y., Yoshihara, Y., Fukai, T., and Okamoto H. (2014). The habenulo-raphe serotonergic circuit encodes an aversive expectation value essential for adaptive active avoidance of danger. Neuron 84, 1034-1048.
  • Kimura, Y., Hisano, Y., Kawahara, A., and Higashijima, S. (2014). Efficient generation of knock-in transgenic zebrafish carrying reporter/driver genes by CRISPR/Cas9-mediated genome engineering. Scientific Reports 4, Article 6545.
  • Okigawa, S., Mizoguchi, T., Okano, M., Tanaka, H., Isoda, M., Jiang, Y., Suster, M., Higashijima, S., Kawakami, K., and Itoh, M. (2014). Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a /V2b cell fate determination. Developmental Biology 391, 196-206.
  • Satou, C., Kimura, Y., Hirata, H., Suster, M.L, Kawakami, K., and Higashijima, S. (2013). Transgenic tools to characterize neuronal properties of discrete populations of zebrafish neurons. Development 140, 3927-3931.
  • Mizuno, H., Sassa, T., Higashijima, S., Okamoto, H., and Miyawaki, A. (2013). Transgenic zebrafish for ratiometric imaging of cytosolic and mitochondrial Ca2+ response in teleost embryo. Cell Calcium 56, 236-245.
  • Hirabayashi, R., Hozumi, S., Higashijima, S., and Kikuchi, Y. (2013). Ddx46 Is Required for Multi-lineage differentiation of hematopoietic stem cells in zebrafish. Stem Cells and Development 22, 2532-2542.
  • Reimer, M.M., Norris, A., Ohnmacht, J., Patani, R., Zhong, Z., Dias, T.B., Kuscha, V., Scott, A.L., Chen, Y., Rozov, S., Frazer, S.L., Wyatt, C., Higashijima, S., Patton, E.E., Panula, P., Chandran, S., Becker, T., and Becker, C.G. (2013). Dopamine from the brain promotes spinal motor neuron generation during development and adult regeneration. Developmental Cell 25, 478-491.
  • Aoki, T., Kinoshita, M., Aoki, R., Agetsuma, M., Aizawa, H., Yamazaki, M., Takahoko, M., Amo, R., Arata, A., Higashijima, S., Tsuboi, T., and Okamoto, H. (2013). Imaging of Neural Ensemble for Retrieval of a Learned Behavioral Program. Neuron 78, 881-894.
  • Kimura, Y., Satou, C., Fujioka, S., Shoji, W., Umeda, K., Ishizuka, T., Yawo, H., and Higashijima, S. (2013). Hindbrain V2a neurons in the excitation of spinal locomotor circuits during zebrafish swimming. Current Biology 23, 843-849.
  • Shimozono, S., Iimura, T., Kitaguchi, T., Higashijima, S., and Miyawaki, A. (2013). Visualization of an endogenous retinoic acid gradient across embryonic development. Nature 496, 363-366.
  • Jusuf, P.R., Albadri, S., Paolini, A., Currie, P., Argenton, F., Higashijima, S., Harris, W.A., and Poggi, L. (2012). Biasing amacrine subtypes in the Atoh7 lineage through expression of Barhl2. J. Neuroscience 32, 13929-13944.
  • Eklof-Ljunggren, E., Haupt, S., Ausborn, J., Dehnisch, I., Uhlen, P., S. Higashijima, S., and El Manira, A. (2012). Origin of excitation underlying locomotion in the spinal circuit of zebrafish. Proc. Natl. Acad. Sci. (USA)109, 5511-5516.
  • Behra, M., Gallardo, V.E., Bradsher, J., Torrado, A., Elkahloun, A., Idol, J., Sheehy, J., Zonies, S., Xu, L., Shaw, K.M., Satou, C., Higashijima, S., Weinstein, B., and Burgess, S.M. (2012). Transcriptional signature of accessory cells in the lateral line, using the Tnk1bp1:EGFP transgenic zebrafish line. BMC Dev. Biol. 12, Article 6.
  • Satou, C., Kimura, Y., and Higashijima, S. (2012). Generation of multiple classes of V0 neurons in zebrafish spinal cord: progenitor heterogeneity and temporal control of neuronal diversity. J. Neuroscience 32, 1771-1783.
  • Asakawa, K., Higashijima, S., and Kawakami, K. (2012). An mnr2b/hlxb9lb enhancer trap line that labels spinal and abducens motor neurons in zebrafish. Developmental Dynamics 241, 327-332.
  • Muto, A., Ohkura, M., Kotani, T., Higashijima, S., Nakai, J., and Kawakami, K. (2011). Genetic visualization with an improved GCaMP reveals spatiotemporal activation of the spinal motor neurons in zebrafish. Proc. Natl. Acad. Sci. (USA) 108, 5425-5430.
  • Wibowo, I., Pinto-Teixeir, F, Satou, C., Higashijima, S., and Lopez-Schier, H. (2011). Compartmentalized Notch signaling sustains epithelialmirror symmetry. Development 138, 1143-1152.
  • Koyama, M., Kinkhabwala, A., Satou, C., Higashijima, S., and Fetcho, J.R. (2011). Mapping a sensory-motor network onto a structural and functional ground plan in the hindbrain. Proc. Natl. Acad. Sci. (USA) 108, 1170-1175.
  • Kinkhabwara, A., Riley, M., Koyama, M., Monen, J., Satou, C., Kimura, Y., Higashijima, S., and Fetcho, J.R. (2011). A structural and functional ground plan for neurons in the hindbrain of zebrafish. Proc. Natl. Acad. Sci. (USA) 108, 1164-1169.
  • Agetsuma, M., Aizawa, H., Aoki, T., Nakayama, R., Takahoko, M., Goto, M., Sassa, T., Amo, R., Shiraki, T., Kawakami, K., Hosoya, T., Higashijima, S., and Okamoto, H. (2010). The habenula is crucial for experience-dependent modification of fear responses in zebrafish. Nature Neuroscience 13, 1354-1356.
  • Nakamura, S., Kobayashi, K., Nishimura, T., Higashijima, S., and Tanaka, M. (2010). Identification of germline stem cells in the ovary of the teleost medaka. Science 328, 1561-1563.
  • Tsutsui, H., Higashijima, S., Miyawaki, A., and Okamura, Y. (2010). Visualizing voltage dynamics in zebrafish heart. J. Physiology 588, 2017-2021.
  • Kani, S., Bae, Y-K, Shimizu T, Tanabe, K., Satou, C., Parsons, M., Scott, E., Baier, H., Higashijima, S., and Hibi, M. (2010). Proneural gene-linked neurogenesis in zebrafish cerebellum. Developmental Biology 343, 1-17.
  • Wada, H., Ghysen, A., Satou, C., Higashijima, S, Kawakami, K., Higashijima, S., and Sakaizumi, M. (2010). Dermal morphogenesis controls lateral line patterning during postembryonic development of teleost fish. Developmental Biology 340, 583-594.
  • Sugiyama, M., Sakaue-Sawano, A., Iimura, T., Fukami, K., Kitaguchi, T., Kawakami, K., Okamoto, H., Higashijima, S., and Miyawaki, A. (2009). Illuminating Cell-Cycle Progression in the Developing Zebrafish Embryo. Proc. Natl. Acad. Sci. (USA) 106, 20812-20817.
  • Satou, C., Kimura, Y., Kohashi, T., Horikawa, K., Takeda, H., Oda, Y., and Higashijima, S. (2009). Functional role of a specialized class of spinal commissural inhibitory neurons during fast escapes in zebrafish. J. Neuroscience 29, 6780-6793.
  • Bae, Y., Kani, S., Shimizu, T., Tanabe, K., Nojima, H., Kimura, Y., Higashijima, S., and Hibi, M. (2009). Anatomy of zebrafish cerebellum and screen for mutations affecting its development. Developmental Biology 300, 406-426.
  • Miyasaka, N., Morimoto, K., Tsubokawa, T., Higashijima, S., Okamoto, H., and Yoshihara, Y. (2009). From the Olfactory Bulb to Higher Brain Centers: Genetic Visualization of Secondary Olfactory Pathways in Zebrafish. J. Neuroscience 29, 4756-4767.
  • Vitorino, M., Jusf, P.R., Maurus, D., Kimura, Y., Higashijima, S., and Harris, W.A. (2009). Vsx2 in the zebrafish retina: restricted lineages through depression. Neural Development 4, Article 14.
  • Miyake, A., Higashijima, S., Kobayashi, D., Narita, T, Jindo, T., Setiamarga, D.H.E., Ohisa, S., Orihara, N, Hibiya, K., Konnno, S., Sakaguchi, S., Hoie, K., Imai, Y., Naruse, K., Kudo, A., and Takeda, H. (2008). Mutation in the abdb gene causes abnormal iron and fatty acid metabolism in developing medaka fish. Development, Growth & Differentiation 50, 703-716.
  • Kimura, Y., Satou, C., and Higashijima, S. (2008). V2a and V2b neurons are generated by the final divisions of pair-producing progenitors in the zebrafish spinal cord. Development 135, 3001-3005.
  • Hossain, Md. I., Iwasaki, H., Okouchi, Y., Chahine, M., Higashijima, S., Nagayama, K., and Okamura, Y. (2008). Enzyme domain affects the movement of the voltage sensor in ascidian and zebrafish VSPs. J. Biol. Chem 283, 18248-59.
  • McLean, D.L., Fan, J., Higashijima, S., Hale, M.E., and Fetcho, J.R. (2007). A topographic map of recruitment in spinal cord. Nature 446, 71-5.
  • Kimura, Y., Okamura, Y., and Higashijima, S. (2006). alx, a zebrafish homolog of Chx10, marks ipsilateral descending excitatory interneurons that participate in the regulation of spinal locomotor circuits. J. Neuroscience 26, 5684-5697.
  • Li, J., Mack J.A., Souren M., Yaksi, M., Higashijima, S., Mione, M., Fetcho, J.R., and Friedrich, R.W. (2005). Early development of functional spatial maps in the zebrafish olfactory bulb. J. Neuroscience 25, 5784-5795.
  • Uemura, O., Okada, Y., Ando, H., Guedj, M., Higashijima, S., Shimazaki, T., Chino, N., Okano, H., and Okamoto, H. (2005). Comparative functional genomics revealed conservation and diversification of three enhancers of the isl1 gene for motor and sensory neuron-specific expression. Developmental Biology 278, 587-606.
  • Higashijima, S., Mandel, G., and Fetcho, J.R. (2004). Distribution of prospective glutamatergic, glycinergic, and GABAergic neurons in embryonic and larval zebrafish. J. Comp. Neurology 480, 1-18.
  • Higashijima, S., Schaefer, M., and Fetcho, J.R. (2004). Neurotransmitter properties of spinal interneurons in embryonic and larval zebrafish. J. Comp. Neurology 480, 19-37.
  • Higashijima, S., Masino, M., Mandel, G., and Fetcho, J.R. (2004). Engrailed-1 expression marks a primitive class of inhibitory spinal interneuron. J. Neuroscience 24, 5827-5839.
  • Li, W.-C., Higashijima, S., Parry, D.M., Roberts, A., and Soffe, S.R. (2004). Primitive roles for inhibitory interneurons in developing frog spinal cord. J. Neuroscience 24, 5840-5848.
  • Higashijima, S., Masino, M., Mandel, G., and Fetcho, J.R. (2003). Imaging neuronal activity during zebrafish behavior with a genetically encoded calcium indicator. J. Neurophysiology 90, 3986-3997.
  • Gleason, M.R., Higashijima, S., Dallman, J., Liu, K., Fetcho, J.R., and Mandel G. (2003). Translocation of CaM kinase II to synaptic sites in vivo. Nature Neuroscience 6, 217-218.
  • Zeller, J., Schneider, V., Malayaman, S., Higashijima, S., Okamoto, H., Gui, J., Lin, S., and Granato M. (2002). Migration of zebrafish spinal motor nerves into the periphery requires multiple myotome-derived cues. Deelopmental Biology 252, 241-256.
  • Ono F., Shcherbatko, A., Higashijima, S., Mandel G., and Brehm, P. (2002). The zebrafish motility mutant twitch once reveals new roles for rapsyn synaptic function. J. Neuroscience 22, 6491-6498.
  • Bingham, S., Higashijima, S., Okamoto, H., and Chandrasekhar A. (2002). The zebrafish trilobite gene is essential for tangential migration of branchiomotor neurons. Developmental Biology 242, 149-160.
  • Ono F., Higashijima, S., Shcherbatko, A., Fetcho, J.R., and Brehm, P. (2001). Paralytic zebrafish lacking acetylcholine receptors fail to localize rapsyn clusters to the synapse. J. Neuroscience 21, 5439-5448.
  • Segawa, H., Miyashita, T., Hirate, Y., Higashijima, S., Chino, N., Uyemura, K., Kikuchi, Y., and Okamoto, H. (2001). Functional repression of Islet-2 by disruption of complex with Ldb impairs peripheral axonal outgrowth in embryonic zebrafish. Neuron 30, 423-436.
  • Higashijima, S., Hotta, Y., and Okamoto, H. (2000). Visualization of cranial motor neurons in live transgenic zebrafish expressing green fluorescent protein under the control of the Islet-1 promoter/enhancer. J. Neuroscience 20, 206-218.
  • Feinstein, Y., Borrell, V., Garcia, C., Burstyn-Cohen, T., Tzarfaty, V., Frumkin, A., Nose, A., Okamoto, H., Higashijima, S., Soriano, E., and Klar, A. (1999). F-spondin and mindin: two structually and functionally related genes expressed in the hippocampus that promote outgrowth of embryonic hippocampal neurons. Development 126, 3637-3648.
  • Higashijima, S., Okamoto, H., Ueno, N., Hotta, Y., and Eguchi, G. (1997). High ferequency generation of transgenic zebrafish which reliably express GFP in whole muscles or the whole body by using promoters of zebrafish origin. Developmental Biology 192, 289-299.
  • Higashijima, S., Nose, A., Eguchi, G., Hotta, Y., and Okamoto, H. (1997). Mindin/F-spondin family: Novel ECM proteins expressed in the zebrafish embryonic axis. Developmental Biology 192, 211-227.
  • Higashijima, S., Shishido, E., Matsuzaki, M., and Saigo, K. (1996). eagle, a member of the steroid receptor superfamily gene, is expressed in a subset of neuroblasts and regulates the fate of their putative progeny in the Drosophila CNS. Development 122, 527-536.
  • Emori, Y., Sugaya, R., Akimaru, H., Higashijima, S., Shishido, E., Saigo, K.,and Homma, Y., (1994). Drosophila phosholipase C-? expressed predominantly in blastderm cells at cellularization and endodermal cells during later embryonic stages. J. Biol. Chem. 269, 19474-19479.
  • Shishido, E., Higashijima, S., Emori, Y., and Saigo, K. (1993). Two FGF-receptor homologues of Drosophila: one is expressed in mesodermal primordium in early embryos. Development 117, 751-761.
  • Tashiro, S., Michiue, T., Higashijima, S., Zenno, S., Ishimaru, S., Takahashi, F., Orihara, M., Kojima, T., and Saigo, K. (1993). Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication. Gene 124, 183-189.
  • Higashijima, S., Michiue, T., Emori, Y., and Saigo, K. (1992). Subtype determination of Drosophila embryonic external sensory organs by redundant homeobox genes BarH1 and BarH2. Genes & Development 6, 1005-1018.
  • Higashijima, S., Kojima, T., Michiue,T., Ishimaru, S. Emori, Y., and Saigo, K. (1992). Dual Bar homeobox genes of Drosophila required in two photoreceptor cells, R1 and R6, and primary pigment cells for normal eye development. Genes & Development 6, 50-60.
  • Kojima, T., Ishimaru, S., Higashijima, S., Takayama, E., Akimaru, H., Sone, M., Emori, Y., and Saigo, K. (1991). Identification of a different-type homeobox gene, BarH1, possibly causing Bar (B) and Om(1D) mutations in Drosophila. Proc. Natl. Acad. Sci. (USA) 88, 4343-4347.