National Insitute for Basic Biology
Fig. 1. Ectopic expression of Connectin.
Schematic diagram showing wild type and ectopic Connectin expression on embryonic muscles and motor nerves. In wild type, Connectin is expressed on a subset of motoneurons (SNa and SNc, shown in red) and muscles (primarily lateral muscles, shown in yellow). In Toll-connectin, Connectin is ectopically expressed on a subset of ventral muscles (also shown in yellow). In MHC-connectin, Connectin is ectopically expressed on all muscles. |
Fig. 2. Connectin functions as an attractive guidance molecule.
In wild type, muscle 12 is innervated by SNb motoneurons (short arrow). Connectin-positive SNa motoneurons innervate more distal muscles. Ectopic Connectin expression on muscle 12 in MHC-connectin changed SNa trajectories: SNa sends an extra axon branch that forms an ectopic nerve ending on muscle 12 (large arrow). |