{"id":5589,"date":"2020-11-16T11:45:13","date_gmt":"2020-11-16T02:45:13","guid":{"rendered":"https:\/\/www.nibb.ac.jp\/abis?p=5589"},"modified":"2022-04-29T14:18:42","modified_gmt":"2022-04-29T05:18:42","slug":"ac20201022","status":"publish","type":"post","link":"https:\/\/www.nibb.ac.jp\/abis\/ac20201022\/","title":{"rendered":"\u3010\u5149\u9855\uff1a\u677e\u7530\uff08\u4eac\u5927\uff09\u3011\u4f0a\u85e4\u96c5\u5f66 \u51c6\u6559\u6388\uff08\u7368\u5354\u533b\u79d1\u5927\uff09\u306e\u8ad6\u6587\u304c  BBA Molecular Basis of Disease  \u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f"},"content":{"rendered":"\r\n<p>\r\n<b>\u3010\u5149\u5b66\u9855\u5fae\u93e1\u652f\u63f4\u62c5\u5f53\uff1a\u677e\u7530\u9053\u884c\uff08\u4eac\u90fd\u5927\u5b66\uff09[2020.10.22]<br>\r\n\u4f0a\u85e4\u96c5\u5f66 \u51c6\u6559\u6388\uff08\u7368\u5354\u533b\u79d1\u5927\u5b66\uff09\u306e\u8ad6\u6587\u304c Biochimica et Biophysica Acta \u2013 Molecular Basis of Disease \u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\r\n<\/b><br><br>\r\n\r\n<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0925443920303422\" rel=\"noopener\" target=\"_blank\">Itoh M., Terada M., Sugimoto H. The zonula occludens protein family regulates the hepatic barrier system in the murine liver. Biochimica et Biophysica Acta \u2013 Molecular Basis of Disease 1867, 165994 (2021) DOI:https:\/\/doi.org\/10.1016\/j.bbadis.2020.165994<\/a><br><br>\r\n\r\n\uff1c\u6982\u8981\uff1e \u672c\u7814\u7a76\u3067\u306f\u3001\u9032\u884c\u6027\u5bb6\u65cf\u6027\u80c6\u6c41\u9b31\u6ede\u75c7\uff14\u578b(PFIC4)\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u3067\u3042\u308b\u30bf\u30a4\u30c8\u7d50\u5408\u69cb\u6210\u5206\u5b50ZO family\u3092\u809d\u81d3\u7279\u7570\u7684\u306b\u6b20\u640d\u3059\u308b\u30de\u30a6\u30b9\u306e\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002ZO family\u306eZO-1\u3068ZO-2\u306e\u4e21\u65b9\u3092\u5931\u3063\u305f\u809d\u7d30\u80de\u3067\u306f\u3001\u30bf\u30a4\u30c8\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3\u69cb\u9020\u306e\u307f\u306a\u3089\u305a\u6b63\u5e38\u306a\u7d30\u80de\u6975\u6027\u304c\u6d88\u5931\u3057\u3066\u304a\u308a\u3001\u5909\u7570\u30de\u30a6\u30b9\u306f6\u9031\u307e\u3067\u306b\u81f4\u6b7b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u306f\u30bf\u30a4\u30c8\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3\u819c\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5c40\u5728\u7570\u5e38\u306a\u3089\u3073\u306b\u6bdb\u7d30\u80c6\u7ba1\u3078\u306e\u6392\u51fa\u3092\u62c5\u3046\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u306e\u767a\u73fe\u4f4e\u4e0b\u304c\u751f\u3058\u3001\u80c6\u6c41\u6210\u5206\u306e\u8840\u4e2d\u3078\u306e\u6f0f\u51fa\u306a\u3069PFIC4\u306b\u7279\u5fb4\u7684\u306a\u75c5\u614b\u304c\u8d77\u304d\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u3046\u3057\u305f\u3053\u3068\u304b\u3089\u3001\u5909\u7570\u30de\u30a6\u30b9\u306fPFIC4\u306e\u52d5\u7269\u30e2\u30c7\u30eb\u306b\u306a\u308a\u3046\u308b\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002ABiS\u30fb\u5149\u5b66\u9855\u5fae\u93e1\u652f\u63f4\uff08\u652f\u63f4\u62c5\u5f53\uff1a\u677e\u7530\u9053\u884c\uff09\u3067\u306f\u4e8c\u5149\u5b50\u9855\u5fae\u93e1\u3092\u7528\u3044\u305f\u809d\u81d3\u306e\u30e9\u30a4\u30d6\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u652f\u63f4\u3092\u884c\u3044\u307e\u3057\u305f\u3002\r\n\r\n<\/p>\r\n\r\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5149\u5b66\u9855\u5fae\u93e1\u652f\u63f4\u62c5\u5f53\uff1a\u677e\u7530\u9053\u884c\uff08\u4eac\u90fd\u5927\u5b66\uff09[2020.10.22] \u4f0a\u85e4\u96c5\u5f66 \u51c6\u6559\u6388\uff08\u7368\u5354\u533b\u79d1\u5927\u5b66\uff09\u306e\u8ad6\u6587\u304c Biochimica et Biophysica Acta \u2013 Molecular Basis of Dise [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5],"tags":[],"class_list":["post-5589","post","type-post","status-publish","format-standard","hentry","category-achievement"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/posts\/5589","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/comments?post=5589"}],"version-history":[{"count":1,"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/posts\/5589\/revisions"}],"predecessor-version":[{"id":7447,"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/posts\/5589\/revisions\/7447"}],"wp:attachment":[{"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/media?parent=5589"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/categories?post=5589"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/tags?post=5589"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}