{"id":3311,"date":"2018-09-19T16:06:51","date_gmt":"2018-09-19T07:06:51","guid":{"rendered":"https:\/\/www.nibb.ac.jp\/abis?p=3311"},"modified":"2022-04-29T14:34:33","modified_gmt":"2022-04-29T05:34:33","slug":"ac20180912","status":"publish","type":"post","link":"https:\/\/www.nibb.ac.jp\/abis\/ac20180912\/","title":{"rendered":"\u3010\u96fb\u9855\uff1a\u5c0f\u6c60\uff08\u9806\u5929\u5802\uff09\u3011\u6851\u539f\u77e5\u6a39\u7279\u4efb\u52a9\u6559\uff08\u6771\u5927\uff09\u306e\u8ad6\u6587\u304c  PNAS \u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f"},"content":{"rendered":"\r\n<p><b>\u3010\u96fb\u5b50\u9855\u5fae\u93e1\u652f\u63f4\u62c5\u5f53\uff1a\u5c0f\u6c60\u6b63\u4eba\uff08\u9806\u5929\u5802\u5927\u5b66\uff09\u3011[2018.09.12]<br>\r\n\u6851\u539f\u77e5\u6a39 \u7279\u4efb\u52a9\u6559\uff08\u6771\u4eac\u5927\u5b66\uff09\u306e\u8ad6\u6587\u304c Proceedings of the National Academy of Sciences of the United States of America \u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\r\n<\/b><br><br>\r\n\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5 \u75c5\u56e0\u30bf\u30f3\u30d1\u30af\u8ceaLRRK2\u306e\u95a2\u308f\u308b\u65b0\u898f\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u6a5f\u69cb\u306e\u767a\u898b<br><br>\r\n<a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.1812196115\" rel=\"noopener\" target=\"_blank\">Eguchi T., Kuwahara T., Sakurai M., Komori T., Fujimoto T., Ito G., Yoshimura S.I., Harada A., Fukuda M., Koike M., Iwatsubo T. LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis. Proc Natl Acad Sci U S A (2018) DOI:10.1073\/pnas.1812196115<\/a><br><br>\r\n\r\n\uff1c\u6982\u8981\uff1e\u672c\u7814\u7a76\u3067\u306f\u3001\u5bb6\u65cf\u6027\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u75c5\u56e0\u30ad\u30ca\u30fc\u30bcLRRK2\uff08leucine-rich repeat kinase 2\uff09\u3068\u3001\u305d\u306e\u57fa\u8cea\u3067\u3042\u308bRab\u30d5\u30a1\u30df\u30ea\u30fc\u4f4e\u5206\u5b50\u91cfG\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u95a2\u308f\u308b\u65b0\u898f\u306e\u30ea\u30bd\u30bd\u30fc\u30e0\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u6a5f\u69cb\u3092\u767a\u898b\u3057\u3001\u30b9\u30c8\u30ec\u30b9\u4f9d\u5b58\u7684\u306aRab\u30ea\u30f3\u9178\u5316\u3092\u4ecb\u3057\u305f\u30ea\u30bd\u30bd\u30fc\u30e0\u6052\u5e38\u6027\u7dad\u6301\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002ABiS\u30fb\u96fb\u5b50\u9855\u5fae\u93e1\u652f\u63f4\uff08\u652f\u63f4\u62c5\u5f53\uff1a\u5c0f\u6c60\u6b63\u4eba\uff09\u3067\u306f\u51cd\u7d50\u8d85\u8584\u5207\u7247\u6cd5\u306b\u3088\u308bLRRK2\u306e\u5c40\u5728\u89e3\u6790\u306e\u652f\u63f4\u3092\u884c\u3044\u307e\u3057\u305f\u3002<br><br>\r\n\r\n\r\n<a href=\"https:\/\/www.m.u-tokyo.ac.jp\/news\/press.html#20180911\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.nibb.ac.jp\/abis\/wp-content\/uploads\/2022\/04\/b_sbrowse.png\" alt=\"\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\" \/> <font color=\"#0077CC\">\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\uff08\u6771\u4eac\u5927\u5b66\u306e\u30b5\u30a4\u30c8\uff09 <\/font><\/a>\r\n<\/p>\r\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u96fb\u5b50\u9855\u5fae\u93e1\u652f\u63f4\u62c5\u5f53\uff1a\u5c0f\u6c60\u6b63\u4eba\uff08\u9806\u5929\u5802\u5927\u5b66\uff09\u3011[2018.09.12] \u6851\u539f\u77e5\u6a39 \u7279\u4efb\u52a9\u6559\uff08\u6771\u4eac\u5927\u5b66\uff09\u306e\u8ad6\u6587\u304c Proceedings of the National Academy of Sciences of the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5],"tags":[],"class_list":["post-3311","post","type-post","status-publish","format-standard","hentry","category-achievement"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/posts\/3311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/comments?post=3311"}],"version-history":[{"count":3,"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/posts\/3311\/revisions"}],"predecessor-version":[{"id":7470,"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/posts\/3311\/revisions\/7470"}],"wp:attachment":[{"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/media?parent=3311"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/categories?post=3311"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nibb.ac.jp\/abis\/wp-json\/wp\/v2\/tags?post=3311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}