文部科学省科学研究費特定領域研究「性分化機構の解明」 *

研究成果

杉本 幸彦 SUGIMOTO, Yukihiko
京都大学大学院薬学研究科
研究項目A02 「脳の性分化と行動の解析」
研究課題 プロスタグランジンE2による視索前野スパイン形成と性行動発現の分子基盤

2006年発表論文

Quantification of the number of EP3 receptors on a living CHO cell surface by the AFM. H. Kim, H. Arakawa, N. Hatae, , Y. Sugimoto, O. Matsumoto, T. Osada, , A. Ichikawa, and A. Ikai. Ultramicroscopy. in press 2006

2005年発表論文

Prostaglandin E receptor EP3 deficiency modifies tumor outcome in mouse two-stage skin carcinogenesis. Y. Shoji, M. Takahashi, N. Takasuka, N. Niho, T. Kitamura, H. Sato, T. Maruyama, Y. Sugimoto, S. Narumiya, T. Sugimura, and K. Wakabayashi. Carcinogenesis 26, 2116-2122, 2005

Critical role of protein kinase C betaII in activation of mast cells by monomeric IgE. Y. Liu, K. Furuta, R. Teshima, N. Shirata, Y. Sugimoto, A. Ichikawa, and S. Tanaka. J. Biol. Chem. 280, 38976-38981, 2005

Prostaglandin E2 stimulates granulocyte-colony stimulating factor production via the prostanoid EP2 receptor in mouse peritoneal neutrophils. Y. Sugimoto, Y. Fukada, D. Mori, S. Tanaka, H. Yamane, Y. Okuno, K. Deai, S. Tsuchiya, G. Tsujimoto, and A. Ichikawa. J. Immunol. 175, 2606-2612, 2005

Takasaki, I., Nojima, H., Shiraki, K., Sugimoto, Y., Ichikawa, A., Ushikubi, F., Narumiya, S., and Kuraishi, Y. Involvement of cyclooxygenase-2 and EP(3) prostaglandin receptor in acute herpetic but not postherpetic pain in mice. Neuropharmacology. in press (2005)

Kunikata, T., Yamane, H., Segi, E., Matsuoka, T., Sugimoto, Y., Tanaka, S., Tanaka, H., Nagai, H., Ichikawa, A., and Narumiya, S. Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3. Nature Immunol. 6, 524-531. (2005)

Moriyama, T., Higashi, T., Togashi, K., Iida, T., Segi, E., Sugimoto, Y., Tominaga, T., Narumiya, S., and Tominaga, M. Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. Molecular Pain. 1, 3. (2005)

Foyouzi, N., Cai, Z., Sugimoto, Y., and Stocco, C. Changes in the expression of steroidgenic and antioxidant genes in the mouse corpus luteum during luteolysis. Biol. Reprod. 72,1134-1141. (2005)

Tanaka, S., Mikura, S., Hashimoto, E., Sugimoto, Y., and Ichikawa, A. Ca(2+) influx-mediated histamine synthesis and IL-6 release in mast cells activated by monomeric IgE. Eur. J. Immunol. 35, 460-468 (2005)

Hirasawa, A., Tsumaya, K., Awaji, T., Katsuma, S., Adachi, T., Yamada, M., Sugimoto, Y., Miyazaki, S., Tsujimoto, G. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nature Med. 11, 90-94. (2005)

2004年発表論文

Tsuboi, H., Sugimoto, Y., Kainoh, T, and Ichikawa, A. Prostanoid EP4 receptor is involved in suppression of 3T3-L1 adipocyte differentiation. Biochem. Biophys. Res. Commun. 322, 1066-1072 (2004)

Sugimoto, Y., Tsuboi, H., Okuno, Y., Tamba, S., Tsuchiya, S., Tsujimoto, G., and Ichikawa, A. Microarray evaluation of EP4 receptor mediated prostaglandin E2 suppression of 3T3-L1 adipocyte differentiation. Biochem. Biophys. Res. Commun. 322, 911-917 (2004)

Sugimoto, Y., Nakato, T., Kita, A., Takahashi, Y., Hatae, N., Tabata, H., Tanaka, S., and Ichikawa, A. A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors. J. Biol. Chem. 279, 11016-11026 (2004)

Tanaka, S., Deai, K., Konomi, A., Takahashi, K., Yamane, H., Sugimoto, Y., Ichikawa, A. Expression of L-histidine decarboxylase in granules of elicited mouse polymorphonuclear leukocytes. Eur. J. Immunol. 34, 1472-1482 (2004)

Shoji, Y., Takahashi, M., Kitamura, T., Watanabe, K., Kawamori, T., Maruyama, T., Sugimoto, Y., Negishi, M., Narumiya, S., Sugimura, T., and Wakabayashi, K. Down-regulation of prostaglandin E receptor subtype EP3 during colon cancer development. Gut. 53, 1151-1158 (2004)