文部科学省科学研究費特定領域研究「性分化機構の解明」 *

研究成果

秦 健一郎 HATA, Ken-ichirou
国立成育医療センター研究所
研究項目A01 「性分化の分子基盤の解析」
研究課題 哺乳類配偶子の雌雄差を規定する分子機構の解明

2006年発表論文

Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation. Nimura, K., Ishida, C., Koriyama,H., Hata, K., Yamanaka, S., Li, E., Ura, K. and Kaneda, Y. Genes Cells. in press

Loss of the maternal imprint in Dnmt3Lmat-/- mice leads to a differentiation defect in the extraembryonic tissue. Arima, T., Hata, K., Tanaka, S., Kusumi, M., Li, E., Kato, K., Shiota, K., Sasaki, H. and Wake, N. Dev. Biol. in press

Evolution of the vertebrate DNMT3 gene family: a possible link between existence of DNMT3L and genomic imprinting. Yokomine, T., Hata, K., Tsudzuki, M. and Sasaki, H. Cytogenet. Genome Res., 113, 75-80, 2006

Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L. Xie, Z.H., Huang, Y.N., Chen, Z.X., Riggs, A.D., Ding, J.P., Gowher, H., Jeltsch, A., Sasaki, H., Hata, K. and Xu, G.L. Hum. Mol. Genet., 15, 1375-1385, 2006

Meiotic and epigenetic aberrations in Dnmt3L-deficient male germ cells. Hata, K., Kusumi, M., Yokomine, T., Li, E. and Sasaki, H. Mol. Reprod. Dev., 73, 116-122, 2006

Stochastic imprinting in the progeny of Dnmt3L-/- females. Arnaud, P., Hata, K., Kaneda, M., Li, E., Sasaki, H., Feil, R. and Kelsey, G. Hum. Mol. Genet., 15, 589-598 2006

2004年発表論文

Kaneda M, Okano M, Hata K, Sado T, Tsujimoto N, Li E and Sasaki H. Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature 429: 900-903, 2004