Understanding of the principles of cell signaling and function
In order to adapt the environment change, cells receive external signals and process the information by a network of chemical reactions, called “intracellular signal transduction”. Once the cell receives an input signal, a series of biochemical reactions in the intracellular signal transduction are in turn launched within the cell, which leads to the amplification, differentiation, and/or integration of the input information. We hope to quantitatively understand the design principle of mechanisms that underlie the intracellular signal transduction.
We visualize the biochemical reactions in the living cells by fluorescence imaging techniques with the biosensors.
To build a quantitative simulation model of cell signaling, we quantify biochemical parameters and physical quantities exerted by cells and tissue.
We decipher the design principle of cell function by manipulating intracellular signaling system with light and small compounds.