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NIBB Department

Division of Morphogenesis

Faculty

Professor
UENO, Naoto
Associate Professor
KINOSHITA, Noriyuki
Assistant Professor
TAKAHASHI, Hiroki
Assistant Professor
SUZUKI, Makoto

Research Summary

The complex morphogenesis of organisms is achieved by consecutive cell-to-cell interactions during development. Recent studies suggest that growth factors play crucial roles in controlling such intercellular communications in a variety of organisms. In addition to secretory factors that trigger intracellular signaling, transcription factors that act in the nucleus to regulate gene expression are thought to be essential for the determination of cell fates. Our main interest is to know how pattern formation and morphogenesis during development are regulated by these growth and transcription factors. We address this problem using several model animals, including frogs, flies and ascidians, and by employing embryology, genetics, molecular and cellular biology, and biochemistry. In addition, we have recently introduced genomics technologies to elucidate the precise genetic programs controlling early development.

Website

Reports

  • Annual Report 2008(PDF)

Contact

Professor UENO, Naoto TEL: +81 564 55 7570 E-mail: nueno@nibb.ac.jp

Selected Publications

Chung, H. A., Yamamoto, T. S., and Ueno, N. (2007). ANR5, an FGF Target Gene Product, Regulates Gastrulation in Xenopus. Curr. Biol. 17, 932-939.

Hotta, K., Yamada, S., Ueno, N., Satoh, N., and Takahashi, H. (2007). Brachyury-downstream notochord genes and convergent extension in Ciona intestinalis embryos. Dev. Growth. Differ. 49, 373-382.

Ogata, S. Morokuma, J. Hayata, T. Kolle, G. Niehrs, C. Ueno, N.* and Cho, K. W.* (*corresponding authors). (2007). TGF-beta signalingmediated morphogenesis: modulation of cell adhesion via cadherin endocytosis. Genes Dev. 21, 1817-1831.

Iioka, H., Iemura, S., Natsume, T. and Kinoshita, N. (2007). Wnt signalling regulates paxillin ubiquitination essential for mesodermal cell motility. Nat. Cell Biol. 9, 813-821.

Lee, R. H., Iioka, H., Ohashi, M., Iemura, S., Natsume, T. and Kinoshita, N. (2007). XRab40 and XCullin5 form a ubiquitin ligase complex essential for the noncanonical Wnt pathway. EMBO J. 26, 3592-3606.