National Institutes of Natural Sciences

National Institute for Basic Biology


NIBB Departments



NONAKA, Shigenori

Associate Professor
NONAKA, Shigenori

Research Summary

In spite of superficially bilateral symmetry, our bodies are highly asymmetric along the left-right (L-R) axis, for example in the placement of internal organs. Our main aim is to clarify the mechanism by which mammalian embryos generate and establish the L-R asymmetry.

PhD Program

This laboratory is currently recruiting graduate students.


Selected Publications

Nonaka, S., Yoshiba, S., Watanabe, D., Ikeuchi, S., Goto, T., Marshall, W. F., and Hamada, H. (2005). De novo formation of left-right asymmetry by posterior tilt of nodal cilia. PLoS Biol 3, e268.

Nonaka, S., Shiratori, H., Saijoh, Y., and Hamada, H. (2002). Determination of left-right patterning of the mouse embryo by artificial nodal flow. Nature 418, 96-99.

Nonaka, S., Tanaka, Y., Okada, Y., Takeda, S., Harada, A., Kanai, Y., Kido, M., and Hirokawa, N. (1998). Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell 95, 829-837.


Associate Professor NONAKA, Shigenori TEL: +81 564 55 7590 E-mail: