In spite of superficially bilateral symmetry, our bodies are highly asymmetric along the left-right (L-R) axis, for example in the placement of internal organs. Our main aim is to clarify the mechanism by which mammalian embryos generate and establish the L-R asymmetry.
This laboratory is currently recruiting graduate students.
Maruyama, A., Oshima, Y., Kajiura-Kobayashi, H., Nonaka, S., Imamura, T., and Naruse, K. (2014). Wide field intravital imaging by two-photon-excitation digital-scanned light-sheet microscopy (2p-DSLM) with a high-pulse energy laser. Biomed Opt Express 5, 3311-3325.
Ichikawa, T., Nakazato, K., Keller, P. J., Kajiura-Kobayashi, H., Stelzer, E. H., Mochizuki, A., and Nonaka, S. (2013). Live imagingof whole mouse embryos during gastrulation: migration analysesof epiblast and mesodermal cells. PLoS One. 8, e64506.
Takao, D., Nemoto, T., Abe, T., Kiyonari, H., Kajiura-Kobayashi,H., Shiratori, H., and Nonaka, S. (2013). Asymmetric distribution ofdynamic calcium signals in the node of mouse embryo during leftrightaxis formation. Dev. Biol. 376, 23-30.
Nonaka, S., Shiratori, H., Saijoh, Y., and Hamada, H. (2002). Determination of left-right patterning of the mouse embryo by artificial nodal flow. Nature 418, 96-99.
Associate Professor NONAKA, Shigenori TEL: +81 564 55 7590 E-mail: firstname.lastname@example.org