My research group explores the genetic networks of biological phenomena whose evolutionary processes are difficult to explain with our present knowledge. This work provides useful information for determining evolutionary mechanisms and processes. In the early part of the last 10 years, we focused on the genetic networks of well-studied model angiosperms, and inferred evolutionary processes (e.g., flower development) based on comparison with homologous genetic networks in other organisms. Using several land plants, including gymnosperms, pteridophytes, bryophytes, and charophytes, I noticed that the moss Physcomitrella patens was a potentially useful organism for exploring genetic networks that had been difficult to study using previously established angiosperm models. I became more interested in studying evolutionary processes with unexplored genetic networks. I believe that such studies using model organisms can provide fruitful evolutionary insights and contribute to comparative studies. For example, the discovery of homeotic gene networks in Drosophila contributed extensively to evolutionary biology before comparative studies began. This discovery, in turn, spurred progress in evolutionary developmental biology. Similar advances have been made in the case of flower development. Therefore, I gradually changed our research focus to the genetic networks of biological phenomena that have not been well studied in angiosperm models but that are important and interesting from an evolutionary perspective, such as microtubule regulations; the initiation, maintenance, and regeneration of pluripotent stem cells; mimicry; sensory movement; and host race change. As usual in science, we have more closely evaluated those research results that were unexpected.
This division is currently recruiting graduate students.
Koshimizu, S., Kofuji, R., Sasaki-Sekimoto, Y., Kikkawa, M., Shimojima, M., Ohta, H., Shigenobu, S., Kabeya, Y., Hiwatashi, Y., Tamada, Y., Murata, T., and Hasebe, M. (2017). Physcomitrella MADS-box genes regulate water supply and sperm movement for fertilization. Nature Plants. 4, 36-45.
Fukushima, K., Fang, X., Alvarez-Ponce, D., Cai, H., Carretero-Paulet, L., Chen, C., Chang, T.-H., Farr, K.M., Fujita, T., Hiwatashi, Y., Hoshi, Y., Imai, T., Kasahara, M., Librado, P., Mao, L., Mori, H., Nishiyama, T., Nozawa, M., Pálfalvi, G., Pollard, S.T., Rozas, J., Sánchez-Gracia, A., Sankoff, D., Shibata, T.F., Shigenobu, S., Sumikawa, N., Uzawa, T., Xie, M., Zheng, C., Pollock, D.D., Albert, V.A., Li, S., and Hasebe, M. (2017). Genome of pitcher plant Cephalotus reveals genetic changes associated with carnivory. Nature Ecology and Evolution 1: 59.
Li, C., Sako, Y., Imai, A., Nishiyama, T., Thompson, K., Kubo, M., Hiwatashi, Y., Kabeya, Y., Karlson, D., Wu, S.-H., Ishikawa, M., Murata, M., Benfey, P.N., Sato, Y., Tamada, Y., and Hasebe, M. (2017). A Lin28 homolog reprograms differentiated cells to stem cells in the moss Physcomitrella patens. Nature Commun. 8: 14242.
Fukushima, K., Fujita, H., Yamaguchi, T., Kawaguchi, M., Tsukaya, H., and Hasebe, M. (2015). Oriented cell division shapes carnivorous pitcher leaves of Sarracenia purpurea. Nature Commun. 6: 6450.
Xu, B., Ohtani, M., Yamaguchi, M., Toyooka, K., Wakazaki, M., Sato, M., Kubo, M., Nakano, Y., Sano, R., Hiwatashi, Y., Murata, T., Kurata, T., Yoneda, A., Kato, K., Hasebe, M., and Demura, T. (2014). Contribution of NAC transcription factors to plant adaptation to land. Science 343: 1505-1508.
Murata, T., Sano, T., Sasabe, M., Nonaka, S.,Nature Commun. 4, 1967.
Sakakibara, K., Ando, S., Yip, H.K., Tamada, Y., Hiwatashi, Y., Murata, T., Deguchi, H., Hasebe, M., and Bowman, J.L. (2013). KNOX2 genes regulate the haploid-to-diploid morphological transition in land plants. Science 339, 1067-1070.
Professor HASEBE, Mitsuyasu E-mail: email@example.com