The complex morphogenesis of organisms is achieved by consecutive cell-to-cell interactions during development. Recent studies suggest that growth factors play crucial roles in controlling such intercellular communications in a variety of organisms. In addition to secretory factors that trigger intracellular signaling, transcription factors that act in the nucleus to regulate gene expression are thought to be essential for the determination of cell fates. Our main interest is to know how pattern formation and morphogenesis during development are regulated by these growth and transcription factors. We address this problem using several model animals, including frogs, mouse, zebrafish and ascidians, and by employing embryology, genetics, molecular and cellular biology, and biochemistry. Recently, we have been exploring a new field of developmental biology in which physical force generated within embryo is considered.
This division is currently recruiting graduate students.
Kinoshita, N., Hashimoto, Y., Yasue, N., Suzuki, M., Cristea, I.M. and Ueno, N. (2020). Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis. Cell Rep. 30, 3875-3888.
Hashimoto, Y., Kinoshita, N., Greco, T., Federspiel, J., Beltran, P.J., Ueno, N. and Cristea, I.M. (2019). Mechanical Force Induces Phosphorylation-Mediated Signaling that Underlies Tissue Response and Robustness in Xenopus Embryos. Cell Syst. 8, 226- 241.
Tominaga, H., Satoh, N., Ueno, N., and Takahashi, H. (2018). Enhancer activities of amphioxus Brachyury genes in embryos of the ascidian, Ciona intestinalis. Genesis 56, e23240.
Shinoda, T., Nagasaka, A., Inoue, Y., Higuchi, R., Minami, Y., Kato, K., Suzuki, M., Kondo, T., Kawaue, T., Saito, K., Ueno, N., Fukazawa, Y., Nagayama, M., Miura, T., Adach, T. and Miyata, T. (2018). Elasticity-based boosting of neuroepithelial nucleokinesis via indirect energy transfer from mother to daughter. PLoS Biol. 16, e2004426.
Hayashi, K. Yamamoto, T.S. and Ueno, N. (2018). Intracellular calcium signal at the leading edge regulates mesodermal sheet migration during Xenopus gastrulation. Sci. Rep. 8, 2433.
Suzuki, M., Sato, M., Koyama, H., Hara, Y., Hayashi, K., Yasue, N., Imamura, H., Fujimori, T., Nagai, T., Cambell, R.E., and Ueno, N. (2017). Distinct intracellular Ca2+ dynamics regulate apical constriction and differentially contribute to neural tube closure. Development 144, 1307-1316.
Negishi, T., Miyazaki, N., Murata, K., Yasuo, H. and Ueno, N. (2016). Physical association between a novel plasma-membrane structure and centrosome orients cell division. eLife 5, e16550.
Professor UENO, Naoto TEL: +81 564 55 7570 E-mail: email@example.com