The complex morphogenesis of organisms is achieved by consecutive cell-to-cell interactions during development. Recent studies suggest that growth factors play crucial roles in controlling such intercellular communications in a variety of organisms. In addition to secretory factors that trigger intracellular signaling, transcription factors that act in the nucleus to regulate gene expression are thought to be essential for the determination of cell fates. Our main interest is to know how pattern formation and morphogenesis during development are regulated by these growth and transcription factors. We address this problem using several model animals, including frogs, mouse, zebrafish and ascidians, and by employing embryology, genetics, molecular and cellular biology, and biochemistry. Recently, we have been exploring a new field of developmental biology in which physical force generated within embryo is considered.
This division is currently recruiting graduate students.
Morita, H., Kajiura-Kobayashi, H. Takagi, C., Yamamoto, T.S., Nonaka, S. ＆ Ueno, N. (2012). Cell movements of the deep layer of non-neural ectoderm underlie complete neural tube closure in Xenopus. Development 139 (8): 1417-1426.
Morita, H., Nandadasa, S., Yamamoto, T.S., Terasaka-Iioka,C., Wylie, C., & Ueno, N. (2010) . Nectin-2 and N-cadherin interact through extracellular domains and induce apical accumulation of F-actin in apical constriction of Xenopus neural tube morphogenesis. Development 137(8): 1315-1325.
Shindo, A., Hara, Y., Yamamoto, T.S., Ohkura, M., Nakai, J., and Ueno, N. (2010). Tissue-tissue interaction-triggered calcium elevation is required for cell polarization during Xenopus gastrulation. PLoS One 5, e8897.
Goda, T, Takagi, C. & Ueno, N. (2009). Xenopus Rnd1 and Rnd3 GTP-binding proteins are expressed under the control of segmentation clock and required for somite formation. Developmental Dynamics 238(11): 2867-2876.
Tao, H., Suzuki, M., Kiyonari, H., Abe, T., Sasaoka, T. & Ueno, N. (2009). Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity PNAS 106:14426-14431 (2009)
Professor UENO, Naoto TEL: +81 564 55 7570 E-mail: email@example.com