NIBB Departments

LABORATORY OF NUCLEAR DYNAMICS

Faculty

MIYANARI, Yusuke

Specially appointed Associate Professor
MIYANARI, Yusuke

Research Summary

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A fundamental question in biology is to understand the mechanisms underlying cell-fate decision. Genomic reprogramming after mammalian fertilization reverts terminally differentiated gametes into toti- or pluripotent state to start a new developmental program. The cell lineage allocation is accompanied by drastic changes in the pattern of gene expression, epigenetic configurations, and nuclear organization. We are studying functional roles of nuclear dynamics in cell lineage-allocation by deciphering the molecular mechanisms underlying remodeling of nuclear organization and their effects on developmental gene expression, using mouse embryos and ES cells as model systems.

 

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Website

Reports

Selected Publications

Miyanari, Y. (2014). TAL effector-mediated genome visualization (TGV). Methods.

 

Miyanari, Y*., Ziegler-Birling, C., and Torres-Padilla, M.E*. (2013). Live visualization of chromatin dynamics with fluorescent TALEs. Nat Struct Mol Biol 20, 1321-1324.

 *Corresponding authors. This article was highlighted by Nature Methods.

 

Li, Y*., Miyanari, Y*., Shirane, K., Nitta, H., Kubota, T., Ohashi, H., Okamoto, A., and Sasaki, H. (2013). Sequence-specific microscopic visualization of DNA methylation status at satellite repeats in individual cell nuclei and chromosomes. Nucleic Acids Res 41, e186.

*Equal contribution

 

Miyanari, Y., and Torres-Padilla, M.E. (2012). Control of ground-state pluripotency by allelic regulation of Nanog. Nature 483, 470-473.

 

Miyanari, Y., Atsuzawa, K., Usuda, N., Watashi, K., Hishiki, T., Zayas, M., Bartenschlager, R., Wakita, T., Hijikata, M., and Shimotohno, K. (2007). The lipid droplet is an important organelle for hepatitis C virus production. Nat Cell Biol 9, 1089-1097.

*Highlighted by Hepatology

Contact

Associate Professor (Specially appointed) MIYANARI Yusuke   E-mail: miyanari@nibb.ac.jp  TEL: 0564-59-5850

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