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National Institutes of Natural Sciences

National Institute for Basic Biology

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NIBB Conferences - Conference

The 62nd NIBB Conference "Force in Development"

Organizers Lance Davidson (Univ. Pittsburgh, USA)
Toshihiko Fujimori (NIBB, Japan)
Shigeo Hayashi (RIKEN CDB, Japan)
Carl-Philipp Heisenberg (IST, Austria, Austria)
Kenji Matsuno (Osaka Univ., Japan)
Hiroyuki Takeda (Univ. Tokyo, Japan)
Naoto Ueno
Venue Okazaki Conference Center, Okazaki, Japan
Date Nov. 17-19, 2014
Link Official Website (http://www.nibb.ac.jp/conf62/)
Poster The 62nd NIBB Conference

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For the past 30 years, in the field of developmental biology, the primary focus has been on elucidating the role of genes on developmental regulation, with biologists pouring the bulk of their time and effort into the investigation of genes, proteins, and their signal transduction systems, that forms the central dogma. It is indisputable that genes and proteins are absolutely required components exerting fundamental biological actions, however, in recent years new light has been shed on the importance of physical forces generated by the shape-change and movement of cells and tissues, as well as the responses of cells and tissues to such forces in developmental processes making elucidation of these physical forces a rising hot-topic in the biological sciences.
 

In order to capitalize on this opportunity, the 62nd NIBB Conference “Force in Development” was planned as an international convention. We were very fortunate that my colleagues Professor Carl-Philipp Heisenberg (the Institute of Science and Technology, Austria), and Professor Lance Davidson (the University of Pittsburgh), as well as Professor Toshihiko Fujimori (National Institute for Basic Biology) who lead this emerging field together with Drs, Kenji Matsuno (Osaka Univeristy), Shigeo Hayashi (University of Tokyo), and Hiroyuki Takeda (Nagoya University) helped arrange the final program. The meeting was held at the Okazaki Conference Center from November 17th to the 19th of 2014. With three keynote speakers, 21 lectures by invited researchers, Six sessions (Cellular Dynamics During Morphogenesis I, Cellular Dynamics During Morphogenesis II, Hemodynamics in Organogenesis, Symmetry Breaking of Cell and Tissue, Physical Environment of Embryos, Mechanics in Cell Migration) including of seven short talks, and 44 poster presentations; the total number of participants was over 130 people. The Mecanobiology field has already existed for a long time, however, rather than cultured cells, the effects of force on multicellular systems, especially dynamics of cells and tissues which alter the physical environment of the embryo and how this impacts morphogenesis was the main theme of this conference. We are extremely grateful that top-class researchers from around the world were willing to gather in Okazaki during their tight schedules. This meeting, bringing renowned researchers together made it possible to deeply explore the theme of the conference, and we believe this will be seen as an epoch-making meeting for the future development of this field. In addition, with so many young researchers from home and abroad who participated in the poster presentations and discussions I feel that this specific area is growing exponentially. During the symposium, in addition to the mixer at the Poster Session Hall that all participants attended, there was also a cozy dinner in a 'Yakitoriya' centered on the invited speakers. Rather than a formal dinner, we enjoyed the lively conversations of more than 40 individuals, with participants changing seats and having chats that were not only focused on research but also revealing the personalities of those attending. We are confident that these connections will become the foundation of future collaborative research and international cooperation.
 

The conference was possible because of three research groups all of which are supported by the Grant-in-Aid for Scientific Research on Innovative Areas (MEXT, Japan): “From molecules and cells to organs: trans-hierarchical logic for higher-order pattern and structures” (Project leader: Hiroyuki Takeda),  “Cross-talk between moving cells and microenvironment as a basis of emerging order in multicellular systems” (Project leader: Takaki Miyata, Nagoya University), and “Cell community in early mammalian development” (Project leader: Toshihiko Fujimori), I would like to express my gratitude for their generous support for this meeting.

Naoto Ueno (On behalf of the organizers)
 

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Program

 

November 17 (Mon) at the Okazaki Conference Center (OCC)
09:00 - 09:20 Registration
   
Opening Remarks
09:20 - 09:30 Masayuki Yamamoto (Director General, National Institute for Basic Biology, Japan)
   
Plenary 1  
Chair: Naoto Ueno

09:30 - 10:20

 

“Interplay of cell dynamics and epithelial tension during morphogenesis of the Drosophial pupal wing”
  Suzanne Eaton (The Max Planck Institute of Molecular Cell Biology and Genetics, Germany)
   
Session 1: Cellular dynamics during morphogenesis I
Chair: Naoto Ueno

10:20 - 10:50

 

“Sequential Contraction and Localized Exchange of Apical Junctions Drives Unidirectional Zippering and Neural Tube Closure in a Simple Chordate” 
  Edwin Munro (University of Chicago, USA)
   
10:50 - 11:10 Coffee Break
   
11:10 - 11:40 “Mechanical stability and instability in epithelial tube morphogenesis”
  Shigeo Hayashi (RIKEN Center for Developmental Biology, Japan)
   
11:40 - 12:10 “Role of spatial pattern of contracting cells in tissue invagination”
  Yasuhiro Inoue (Kyoto University, Japan)
   
12:10 - 12:20 Group Photo
   
12:20 - 13:10 Lunch
   
Session 2: Cellular dynamics during morphogenesis II
Chair: Toshihiko Fujimori and Kenji Matsuno
13:10 - 13:40 “Ca2+ dynamics during neural tube formation of Xenopus”
  Naoto Ueno (National Institute for Basic Biology, Japan)
   
13:40 - 14:00 Short Talk from Poster No. 26
  “Filopodia-Mediated Fibrillar Adhesion and Vascular Constriction Facilitate Patterned Deposition of Fibronectin Pillars that Bridge Somites and the Endoderm”
  Yuki Sato (Kyushu University, Japan)
   
14:00 - 14:30 “Biomechanical control of tissue morphogenesis by GPCR signalling”
  Thomas Lecuit (The Developmental Biology Institute of Marseille, France)
   
14:30 - 14:50 Coffee Break
   
14:50 - 15:20 “Development, validation and applications of Bayesian force/stress inference”
  Kaoru Sugimura (Kyoto University, Japan)
   
15:20 - 15:50 “The mechanical control of epithelial invagination via α-Catenin”
  Yu-Chiun Wang (RIKEN Center for Developmental Biology, Japan)
   
15:50 - 16:10 Short Talk from Poster No. 32
  “Tissue Force Coupling Drives Collective Cell Migration and Large-Scale Tissue Flow in Zebrafish”
  Michael Smutny (Institute of Science and Technology Austria, Austria)
   
16:10 - 16:30 Coffee Break
   
Session 3: Hemodynamics in organogenesis
Chair: Takeo Matsumoto 
16:30 - 17:00 “Hemodynamic Forces as a Regulator of Cardiogenesis and Circulatory Homeostasis”
  Toshihiko Ogura (Tohoku University, Japan)
   
17:00 - 17:30 “Mechanism of hemodynamics sensing during cardiovascular development”
  Julien Vermot (Institut de Génétique et de Biologie Moléculaire et Cellulaire, France)
   
17:30 - 17:50 Short Talk from Poster No. 18
  “Modeling Cell-cell interaction and Random Cell Movement in collective migration of MDCK cells”
  Takashi Miura (Kyushu University, Japan)
   
Poster Session  
18:00 - 20:00  Poster Session & Mixer     Poster Title (PDF 70KB)
   
   
November 18 (Tue) at OCC
Plenary 2  
Chair: Carl-Philipp Heisenberg
09:00 - 09:50 “Embryo-scale integration of tissue mechanics”
  Maria Leptin (European Molecular Biology Laboratory, Germany)
   
Session 4: Symmetry breaking of cell and tissue
Chair: Carl-Philipp Heisenberg

09:50 - 10:20

 

“Active torque generation by the actomyosin cell cortex for left/right symmetry breaking”
  Stephan W. Grill (Biotechnology Center TU Dresden, Germany)
   

10:20 - 10:50

 

“Cell Chirality Induces Mechanical Force Driving the Left-Right Directional Rotations of the Gut in Drosophila”
  Kenji Matsuno (Osaka University, Japan)
   
10:50 - 11:10 Coffee Break
   
11:10 - 11:40 “PCP Pathway and Cellular Geometric Pattern in Oviduct Morphogenesis”
  Toshihiko Fujimori (National Institute for Basic Biology, Japan)
   
11:40 - 12:10 “Establishment of robust compartments in fish somites along the dorsoventral axis”
  Hiroyuki Takeda (The University of Tokyo, Japan)
   
12:10 - 12:30 Short Talk from Poster No. 23
  “Vertex Model for Simulating Mechanics-Based Multicellular Dynamics in 3D”
  Satoru Okuda (RIKEN Center for Developmental Biology, Japan)
   
12:30 - 13:30 Lunch
   
Session 5: Physical environment of embryos
Chair: Shigeo Hayashi and Takaki Miyata

13:30 - 14:00

 

“Forces and Regulation of Cell Sheet Morphogenesis During Dorsal Closure in Drosophila”
  Daniel Kiehart (Duke University, USA)
   

14:00 - 14:30

 

“Biomechanical analyses of Xenopus laevis embryo: Toward estimation of stress and strain distributions during morphogenesis”
  Takeo Matsumoto (Nagoya Institute of Technology, Japan)
   

14:30 - 15:00

 

“Extracellular ATP and its receptor P2Y2 mediate a closed-loop feedback circuit for the mechanical control of gastrulation”
  Lance Davidson (The University of Pittsburgh, USA)
   
15:00 - 15:20 Coffee Break
   

15:20 - 15:50

 

“Seeing How Mammalian Life Starts: Quantitative Single-Cell Imaging of Living Embryos”
  Nicolas Plachta (European Molecular Biology Laboratory Australia, Australia)
   
15:50 - 16:10 Short Talk from Poster No. 10
  “Measuring force between cells during development by FRET”
  Yutaro Hori (The University of Tokyo, Japan) and Yusuke Mii (National Institute for Basic Biology, Japan)
   
16:10 - 16:20 Short Break
   

16:20 - 16:50

 

“Adhesion Disengagement and Maintenance of Tissue Integrity during Apoptosis in Epithelial Tissue”
  Yusuke Toyama (National University of Singapore, Singapore)
   
Plenary 3  
Chair: Takaki Miyata
16:50 - 17:40 “Contact-Dependent Promotion of Cell Movement”
  Masatoshi Takeichi (RIKEN Center for Developmental Biology, Japan)
   
   
November 19 (Wed) at OCC
Session 6: Mechanics in cell migration
Chair: Lance Davidson

09:00 - 09:30

 

“Nuclear Traffic and Mechanics under High-degree Pseudostratification: Lessons from Mammalian Cerebral Neuroepithelia”
  Takaki Miyata (Nagoya University Graduate School of Medicine, Japan)
   
09:30 - 09:50 Short Talk from Poster No. 24
  “Invasive Migration Of Drosophila Macrophages During Embryogenesis”
  Aparna Ratheesh (The Institute of Science and Technology Austria, Austria)
   
09:50 - 10:10 Short Talk from Poster No. 16
  “Left-right Asymmetric Planar Cell Polarity Controls Directional Collective Cell Migration in Epithelial Morphogenesis”
  Erina Kuranaga (RIKEN Center for Developmental Biology, Japan)
   
10:10 - 10:30 Coffee Break
   

10:30 - 11:00

 

“Force, Cadherin Adhesions, and the Regulation of Dynamic Cytoskeleton Organization Drives Morphogenetic Collective Cell Migration”
  Gregory Weber (Rutgers, The State University of New Jersey, USA)
   

11:00 - 11:30

 

“Cortical Contractility Triggers a Motile Switch to Fast Amoeboid Migration in 3D Environments”
  Carl-Philipp Heisenberg (The Institute of Science and Technology Austria, Austria)
   
Closing Remarks
11:30 - 11:40  Hiroyuki Takeda (The University of Tokyo, Japan)

 

Conference